|Budget Amount *help
¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|Outline of Final Research Achievements
Stress due to social and environmental stimuli promotes mental illnesses including depression. However, since the mechanism of stress remains elusive, a pharmaceutical strategy targeting stress has not been established. In this study, using repeated social defeat stress, a mouse model of depression, we showed that short-term stress activates dopamine receptors in excitatory neurons in the medial prefrontal cortex and promotes stress resilience, whereas long-term stress activates microglia through innate immune molecules and induces depression-like behaviors. Therefore, this study proposes novel strategies to promote stress resilience for the therapeutic treatment of mental illnesses.