Research Project
Grant-in-Aid for Young Scientists (A)
Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. We showed that the human Mediator subunit MED26 plays a role in the recruitment of transcription elongation complexes, SEC and LEC to the different types of genes.It has been reported that the expression of many genes is strictly controlled and that the dysregulation of the gene expression often causes cancers or leukemias. Since MED26 also regulates the expression of cancer-related genes, it is possible that MED26 is one of the important molecules to regulate carcinogenesis and leukemogenesis.
All 2015 2014 2013 2012 Other
All Journal Article (7 results) (of which Peer Reviewed: 7 results, Open Access: 1 results) Presentation (8 results) (of which Invited: 1 results) Remarks (3 results)
Nature Commun.
Volume: 5 Issue: 1 Pages: 5941-5941
10.1038/ncomms6941
120005621881
eLife
Volume: in press
120005617283
Molecular and cellular biology
120005672365
Oncogene
Volume: In press
J. Neurol.
Volume: 261 Issue: 1 Pages: 224-226
10.1007/s00415-013-7134-5
Cell Rep
Volume: 2(5) Issue: 5 Pages: 1129-36
10.1016/j.celrep.2012.09.031
J. Biol. Chem.
Volume: 287 Issue: 15 Pages: 12050-12059
10.1074/jbc.m111.307678
http://www.hucc.hokudai.ac.jp/~d20505/takahashi/
http://www.hucc.hokudai.ac.jp/~d20505/takahashi/index.html