| Budget Amount *help |
¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|
|---|
| Outline of Final Research Achievements |
We revealed the molecular mechanisms underlying the competence regulation in neural stem/progenitor cells. A certain microRNA is a key regulator for it and this regulatory system is necessary for spatio-temporally specific proper responses to the cell-extrinsic signals (Naka-Kaneda H. et al. PNAS, 2014). This system is also important for the aging of mesenchymal stem/stromal cells (MSCs) and associated with the decline in differentiation potential and expression of secretory factors. We identified a regenerative factor-derived from MSCs for age-related disorders. Upregulation of the factor ameliorates reduction of lymphocytes, insufficient muscle repair capacity, decrease of neural progenitors, and chronic inflammation.
|
