The role of novel metabolite, O-acetyl-ADP-Ribose
Project/Area Number |
24689019
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | University of Toyama |
Principal Investigator |
NAKAGAWA TAKASHI 富山大学, 先端ライフサイエンス拠点, 特命助教 (40610374)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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Keywords | 代謝 / メタボローム / NAD |
Outline of Final Research Achievements |
In this study, I investigated the physiological role of novel metabolite, O-acetyl-ADP-Ribose (OAADPR). First, the system to measure the OAADPR was established by using LC/MS. Next, I focused on the enzyme, Nudt5, which catabolized the OAADPR. I generated the Nudt5- knocked down cell and examined the intracellular metabolism in these cells, and found that various NAD-related metabolites were altered in these cells.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia2016
Author(s)
Akiko Takikawa, Isao Usui , Shiho Fujisaka, Masashi Ikutani, Satoko Senda, Shinpei Hattori, Koichi Tsuneyama, Yukiko Koshimizu, Ran Inoue, Ayumi Tanaka-Hayashi, Takashi Nakagawa, Yoshinori Nagai, Kiyoshi Takatsu, Toshiyasu Sasaoka, Hisashi Mori, Kazuyuki Tobe
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Journal Title
Diabetology International
Volume: 7
Issue: 1
Pages: 59-68
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes.2014
Author(s)
Hikosaka K, Ikutani M, Shito M, Kazuma K, Gulshan M, Nagai Y, Takatsu K, Konno H, Tobe K, Kanno H, Nakagawa T
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Journal Title
J Biol Chem
Volume: 289 (21)
Pages: 14796-14811
Related Report
Peer Reviewed
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[Journal Article] Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.2014
Author(s)
Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T.
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Journal Title
Diabetologia
Volume: 57
Issue: 4
Pages: 819-831
DOI
Related Report
Peer Reviewed / Open Access
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