Mechanisms for selective endocytosis and its involvement in the pathogenesis of cancer and psychiatric disorders
Project/Area Number |
24689021
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Nagoya University |
Principal Investigator |
ENOMOTO Atsushi 名古屋大学, 医学(系)研究科(研究院), 准教授 (20432255)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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Keywords | Girdin / 細胞運動 / エンドサイトーシス / アクチン細胞骨格 / ダイナミン / トランスフェリン受容体 / カドヘリン |
Outline of Final Research Achievements |
Despite the importance of the endocytosis of receptors and cell adhesion proteins, which is essential for various cellular processes, the mechanisms for the specificity and spatial control of the endocytosis have remained unknown. We previously identified the actin-binding protein Girdin that regulates the migration of neuroblasts in the postnatal brain and cancer cells. In the present study, we revealed that Girdin interacts with dynamin, which is central to the scission of membrane vesicles and subsequent endocytosis, to regulate the specificity of endocytosis. By using genetically engineered mice and cultured cells, we also demonstrated that the endocytosis mediated by the Girdin/dynamin complex has a role in the migration of neuroblasts and is involved in aberrant polarization of cancer cells.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Akt-girdin signaling in cancer-associated fibroblasts contributes to tumor progression2015
Author(s)
Yumiko Yamamura, Naoya Asai, Atsushi Enomoto, Takuya Kato, Shinji Mii, Yuji Kondo, Kaori Ushida, Kaoru Niimi, Nobuyuki Tsunoda, Masato Nagino, Shu Ichihara, Koichi Furukawa, Kengo Maeda, Toyoaki Murohara, Masahide Takahashi
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Journal Title
Cancer Research
Volume: 75
Issue: 5
Pages: 813-823
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells.2014
Author(s)
Niimi K, Murakumo Y, Watanabe N, Kato T, Mii S, Enomoto A, Asai M, Asai N, Yamamoto E, Kajiyama H, Shibata K, Kikkawa F, Takahashi M.
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Journal Title
Cancer Sci.
Volume: 105
Issue: 5
Pages: 545-52
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] TRIM27/MRTF-B-Dependent Integrin β1 Expression Defines Leading Cells in Cancer Cell Collectives.2014
Author(s)
Takuya Kato, Atsushi Enomoto, Takashi Watanabe, Hisashi Haga, Sumire Ishida, Yuji Kondo, Koichi Furukawa, Takeshi Urano, Shinji Mii, Liang Weng, Maki Ishida-Takagishi, Masato Asai, Naoya Asai, Kozo Kaibuchi, Yoshiki Murakumo, Masahide Takahashi.
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Journal Title
Cell reports.
Volume: 7
Issue: 4
Pages: 1156-1167
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.2014
Author(s)
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi and Masahide Takahashi.
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Journal Title
EMBO Journal.
Volume: 33
Issue: 18
Pages: 2098-2112
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA2014
Author(s)
Haruko Ota, Takao Hikita, Masato Sawada, Tomoki Nishioka, Mami Matsumoto, Masayuki Komura, Akihisa Ohno, Yukiyo Kamiya, Takuya Miyamoto, Naoya Asai, Atsushi Enomoto, Masahide Takahashi, Kozo Kaibuchi, Kazuya Sobue, Kazunobu Sawamoto
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 4532-4532
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Girdin phosphorylation is crucial for synaptic plasticity and memory: A potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor2014
Author(s)
Tsuyoshi Nakai, Taku Nagai, Motoki Tanaka, Norimichi Itoh, Naoya Asai, Atsushi Enomoto, Masato Asai, Shinnnosuke Yamada, Ali Bin Saifullah, Masahiro Sokabe, Masahide Takahashi, Kiyofumi Yamada
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Journal Title
The Journal of Neuroscience
Volume: 34
Issue: 45
Pages: 14995-15008
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.2013
Author(s)
Watanabe, N., Mii, S., Asai, N., Asai, M., Niimi, K., Ushida, K., Kato, T., Enomoto, A., Ishii, H., Takahashi, M., Murakumo, Y.
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Journal Title
J. Biol. Chem.
Volume: 288
Issue: 15
Pages: 10459-10471
DOI
Related Report
Peer Reviewed
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[Journal Article] Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy.2013
Author(s)
Ueno S, Nishiguchi KM, Tanioka H, Enomoto A, Yamanouchi T, Kondo M, Yasuma TR, Yasuda S, Kuno N, Takahashi M, Terasaki H.
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Journal Title
PLoS One
Volume: 8(11)
Issue: 11
Pages: e81507-e81507
DOI
Related Report
Peer Reviewed
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[Journal Article] Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain2013
Author(s)
Haruko Ota, Takao Hikita, Tomoki Nishioka, Mami Matsumoto, Jun Ito, Naoya Asai, Atsushi Enomoto, Masahide Takahashi, Kozo Kaibuchi, Kazuya Sobue, Kazunobu Sawamoto
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 442
Issue: 1-2
Pages: 16-21
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Mechanisms underlying the integrin beta1 expression that define heterogeneity in migrating cancer cell collectives.
Author(s)
Kato, T., Enomoto, A., Asai, M., Asai, N., Takahashi, M.
Organizer
The American Society of Cell Biology, 2013 Annual Meeting
Place of Presentation
New Orleans(米国)
Related Report
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