| Budget Amount *help |
¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
Despite the importance of the endocytosis of receptors and cell adhesion proteins, which is essential for various cellular processes, the mechanisms for the specificity and spatial control of the endocytosis have remained unknown. We previously identified the actin-binding protein Girdin that regulates the migration of neuroblasts in the postnatal brain and cancer cells. In the present study, we revealed that Girdin interacts with dynamin, which is central to the scission of membrane vesicles and subsequent endocytosis, to regulate the specificity of endocytosis. By using genetically engineered mice and cultured cells, we also demonstrated that the endocytosis mediated by the Girdin/dynamin complex has a role in the migration of neuroblasts and is involved in aberrant polarization of cancer cells.
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