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"Combination-oriented molecular-targeting prevention" of cancer via the activation of TRAIL pathway by targeting microRNA.

Research Project

Project/Area Number 24689031
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Hygiene
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Tomosugi(Horinaka) Mano  京都府立医科大学, 医学(系)研究科(研究院), 講師 (80512037)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsがん / microRNA / TRAIL / 予防 / 癌予防 / アポトーシス / 分子標的併用予防
Outline of Final Research Achievements

TRAIL is a cytokine which can induce apoptosis against cancer cells, and contribute to cancer prevention. We considered possibility of the involvement of microRNA as one of the mechanisms of regulation of TRAIL expression. As the results of examinations for several candidate microRNAs including miR-145, we found that certain microRNA (miR-X) significantly induced the expression of TRAIL in human cancer cells. The activity of TRAIL promoter was up-regulated by the microRNA, miR-X. Furthermore, this study showed that miR-X was partially involved in the mechanism of TRAIL induction by the metabolism product derived from a dietary fiber reported as TRAIL inducer.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (15 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.2015

    • Author(s)
      Ryoichi Tanaka, Mitsuhiro Tomosugi, Mano Horinaka, Yoshihiro Sowa, Toshiyuki Sakai.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 5 Pages: e0125779-e0125779

    • DOI

      10.1371/journal.pone.0125779

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells.2014

    • Author(s)
      Horinaka M, Yoshida T, Tomosugi M, Yasuda S, Sowa Y, Sakai T.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6000-6000

    • DOI

      10.1038/srep06000

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ibuprofen enhances TRAIL-induced apoptosis through DR5 upregulation.2013

    • Author(s)
      Todo M, Horinaka M, Tomosugi M, Tanaka R, Ikawa H, Sowa Y, Ishikawa H, Fujiwara H, Otsuji E, Sakai T
    • Journal Title

      Oncol Rep.

      Volume: 30 Issue: 5 Pages: 2379-2384

    • DOI

      10.3892/or.2013.2713

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] メトホルミンはヒト膵癌細胞に対し、miR-221抑制を介したG1期停止作用と、DR5発現誘導を介したTRAIL感受性増強作用を有する2016

    • Author(s)
      堀中真野、田中良一、友杉充宏、曽和義広、酒井敏行
    • Organizer
      第15回分子予防環境医学研究会
    • Place of Presentation
      栃木
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells.2015

    • Author(s)
      堀中真野、吉田達士、曽和義広、酒井敏行
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] sulindac sulfideによるMZF1発現調節を介したTRAIL感受性増強2015

    • Author(s)
      堀中真野、吉田達士、曽和義広、酒井敏行
    • Organizer
      第19回日本がん分子標的治療学会
    • Place of Presentation
      松山
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] がんの分子標的予防戦略2015

    • Author(s)
      堀中真野、曽和義広、酒井敏行
    • Organizer
      がん予防学術大会2015
    • Place of Presentation
      さいたま
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] microRNA発現調節によるTRAIL発現増強作用の解析2015

    • Author(s)
      堀中真野、酒井敏行
    • Organizer
      第85回日本衛生学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写因子MZF-1を介したsulindac sulfideによるDR5発現誘導機構2015

    • Author(s)
      堀中真野、吉田達士、友杉充宏、曽和義広、酒井敏行
    • Organizer
      第14回分子予防環境医学研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-02-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lactobacilli induce TRAIL production in human PBMC and facilitate natural killer activity against cancer cells.2014

    • Author(s)
      Mano Horinaka, Tatsushi Yoshida, Atsuko Kishi, Kaoru Akatani, Takashi Yasuda, Junji Kouhara, Miki Wakada, Toshiyuki Sakai
    • Organizer
      The 5th Asian-Pacific Topic Conference
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Ibuprofen enhances TRAIL-induced apoptosis through DR5 upregulation. (イブプロフェンによるDR5の発現誘導とTRAIL誘導性アポトーシスの増強)2014

    • Author(s)
      藤堂桃子、堀中真野、友杉充宏、石川秀樹、曽和義広、藤原斉、大辻英吾、酒井敏行
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] イブプロフェンによるTRAIL感受性増強作用2014

    • Author(s)
      堀中真野、藤堂桃子、友杉充宏、田中良一、井川陽菜、曽和義広、石川秀樹、藤原斉、大辻英吾、酒井敏行
    • Organizer
      第21回日本がん予防学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] sulindac sulfideによるTRAIL感受性増強作用2014

    • Author(s)
      堀中真野、吉田達士、友杉充宏、酒井敏行
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 癌の「分子標的併用予防法」の開発―イブプロフェンによるDR5遺伝子の発現誘導とTRAIL誘導性アポトーシスの増強―2014

    • Author(s)
      堀中真野, 藤堂桃子, 友杉充宏, 田中良一, 井川陽菜, 曽和義広, 石川秀樹, 藤原斉, 大辻英吾, 酒井敏行
    • Organizer
      第13回分子予防環境医学研究会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌の分子標的予防の腫瘍免疫への応用.日本衛生学会奨励賞受賞講演.2013

    • Author(s)
      堀中真野
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glyoxalase経路の抑制によるTRAIL感受性の増強2013

    • Author(s)
      堀中真野, 谷口浩也, 酒井敏行
    • Organizer
      第16回日本がん分子標的治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] XIAPやsurvivinの発現抑制を介した、 メチルグリオキサールのTRAIL感受性増強作用2013

    • Author(s)
      堀中真野, 谷口浩也, 吉田達士, 安田周祐, 酒井敏行
    • Organizer
      第20回日本がん予防学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeting glyoxalase pathway enhances TRAIL efficacy by down-regulating the expression of anti-apoptotic molecules.2013

    • Author(s)
      谷口 浩也, 堀中 真野, 矢野 公大, 酒井 敏行
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都府立医科大学 大学院医学研究科 分子標的癌予防医学 ホームページ

    • URL

      http://www.f.kpu-m.ac.jp/k/pubmed/

    • Related Report
      2014 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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