"Combination-oriented molecular-targeting prevention" of cancer via the activation of TRAIL pathway by targeting microRNA.
| Project/Area Number |
24689031
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | がん / microRNA / TRAIL / 予防 / 癌予防 / アポトーシス / 分子標的併用予防 |
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| Outline of Final Research Achievements |
TRAIL is a cytokine which can induce apoptosis against cancer cells, and contribute to cancer prevention. We considered possibility of the involvement of microRNA as one of the mechanisms of regulation of TRAIL expression. As the results of examinations for several candidate microRNAs including miR-145, we found that certain microRNA (miR-X) significantly induced the expression of TRAIL in human cancer cells. The activity of TRAIL promoter was up-regulated by the microRNA, miR-X. Furthermore, this study showed that miR-X was partially involved in the mechanism of TRAIL induction by the metabolism product derived from a dietary fiber reported as TRAIL inducer.
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Report
(5 results)
Research Products
(19 results)
