| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2012: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Outline of Final Research Achievements |
The purpose of this research was the elucidation of the proliferation and self-renewal control mechanism of the hematopoietic stem cells (HSCs) by the cell competition through Flower code or Hippo pathway in the bone marrow niche. For this purpose, we analyzed the effect of these pathways on the regulation of HSCs proliferation at the cell competition. We found that Flower isoform Fwe1 showed proliferative advantage (winner) and Fwe2 indicated recessive (loser). It was suggested that Flower was the indicator to eliminate HSCs of low fitness for the maintenance of tissue homeostasis.
On the other hand, we found that Lats1/2 regulated HSCs proliferation in the cell competition by analyzing of Lats KO HSCs. It was suggested that Hippo signal was also involved in cell competition system of HSCs.
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