Identification of rare risk variants for schizophrenia using target resequencing

• Project/Area Number: 24689046
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Fujita Health University
• Principal Investigator: IKEDA Masashi 藤田保健衛生大学, 医学部, 講師 (60424933)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000); Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
• Keywords: 臨床精神分子遺伝学 / 精神科遺伝学 / ゲノム / 脳神経疾患

Research Abstract

Several epidemiological studies suggests that the genetic risk has significant influence of susceptibility for schizophrenia. Therefore a large number of genetic studies targeting common variants has been carried out, however small number of the risk variants were discovered by such studies. With the progress of next generation sequencing methodology, detecting of rare risk variant is topic for schizophrenia genetics. In this study, we conducted case-control analysis of target resequencing (about 300 genes) and examined burden of rare variants (nonsense or insertion/deletion).
We found no significant enrichment between schizophrenia and controls, but detected trend for significance of over-representation in early-onset of schizophrenia.

Research Products

• [Journal Article] Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population (2014)
  • Author(s): Kajio Y, Kondo K, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N.
  • Journal Title: J Hum Genet Volume: 59 Issue: 1 Pages: 54
  • DOI: 10.1038/jhg.2013.116
  • Peer Reviewed
• [Journal Article] Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia (2013)
  • Author(s): 池田 匡志 他
  • Journal Title: Neuropsychopharmacology Volume: 38 Issue: 10 Pages: 1864-1870
  • DOI: 10.1038/npp.2013.94
  • Peer Reviewed
• [Journal Article] Genome-wide association study of cognitive decline in schizophrenia. (2013)
  • Author(s): Hashimoto R, et al.
  • Journal Title: Am J Psychiatry Volume: 170(6) Issue: 6 Pages: 683-4
  • DOI: 10.1176/appi.ajp.2013.12091228
  • Peer Reviewed
• [Journal Article] Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population (2013)
  • Author(s): Ikeda M, Aleksic B, Yamada K, Iwayama-Shigeno Y, Matsuo K, Numata S, Watanabe Y, Ohnuma T, Kaneko T, Fukuo Y, Okochi T, Toyota T, Hattori E, Shimodera S, Itakura M, Nunokawa A, Shibata N, Tanaka H, Yoneda H, Arai H, Someya T, Ohmori T, Yoshikawa T, Ozaki N, Iwata N
  • Journal Title: Mol Psychiatry Volume: 18(6) Issue: 6 Pages: 636-638
  • DOI: 10.1038/mp.2012.74
  • Peer Reviewed
• [Journal Article] Implication of a rare deletion at distal 16p11.2 in schizophrenia (2013)
  • Author(s): Guha S, Rees E, Darvasi A, Ivanov D, Ikeda M, Bergen SE, Magnusson PK, Cormican P, Morris D, Gill M, Cichon S, Rosenfeld JA, Lee A, Gregersen PK, Kane JM, Malhotra AK, Rietschel M, Nothen MM, Degenhardt F, Priebe L, Breuer R, Strohmaier J, Ruderfer DM, Moran JL, Chambert KD, Sanders AR, Shi J, Kendler K, Riley B, O'Neill T, Walsh D, Malhotra D, Corvin A, Purcell S, Sklar P, Iwata N, Hultman CM, Sullivan PF, Sebat J, McCarthy S, Gejman PV, Levinson DF, Owen MJ, O'Donovan MC, Lencz T and Kirov G
  • Journal Title: JAMA Psychiatry Volume: 70(3) Issue: 3 Pages: 253-60
  • DOI: 10.1001/2013.jamapsychiatry.71
  • Peer Reviewed
• [Journal Article] Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder (2013)
  • Author(s): Lencz T, Guha S, Liu C, Rosenfeld J, Mukherjee S, Derosse P, John M, Cheng L, Zhang C, Badner JA, Ikeda M, Iwata N, Cichon S, Rietschel M, Nothen MM, Cheng AT, Hodgkinson C, Yuan Q, Kane JM, Lee AT, Pisante A, Gregersen PK, Pe'er I, Malhotra AK, Goldman D and Darvasi A
  • Journal Title: Nat Commun Volume: 4 Issue: 1 Pages: 2739-2739
  • DOI: 10.1038/ncomms3739
  • Peer Reviewed
• [Journal Article] Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder (2013)
  • Author(s): Esaki K, Kondo K, Hatano M, Saito T, Kishi T, Umene-Nakano W, Yoshimura R, Nakamura J, Ozaki N, Ikeda M and Iwata N
  • Journal Title: Journal of human genetics Volume: 58(8) Issue: 8 Pages: 568-9
  • DOI: 10.1038/jhg.2013.52
  • NAID: 10031195290
  • Peer Reviewed
• [Journal Article] Genome-wide association study of atypical psychosis (2013)
  • Author(s): 金沢 徹文 他
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Volume: 162 Issue: 7 Pages: 679-686
  • DOI: 10.1002/ajmg.b.32164
  • Peer Reviewed
• [Journal Article] Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study (2013)
  • Author(s): Kondo K, Ikeda M, Kajio Y, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
  • Journal Title: PLoS One Volume: 8 Issue: 8 Pages: e70964-e70964
  • DOI: 10.1371/journal.pone.0070964
  • URL: https://pure.teikyo.jp/en/publications/e96a4517-a758-4417-a82d-8d920315d238
  • Peer Reviewed
• [Journal Article] An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders (2012)
  • Author(s): Matsunaga S, Ikeda M, Kishi T, Fukuo Y, Aleksic B, Yoshimura R, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Kitajima T, Iwata N
  • Journal Title: Neurosci Lett Volume: 529 Issue: 1 Pages: 66
  • DOI: 10.1016/j.neulet.2012.08.070
  • Peer Reviewed
• [Presentation] Shared risk between Methamp hetamine-induced psychosis and schizop hrenia (2012)
  • Author(s): 池田匡志
  • Organizer: World Congress of Psychiatric Ge netics
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2012-10-16
• [Presentation] Shared risk between Methamphetamine-induced psychosis and schizop hrenia (2012)
  • Author(s): 池田匡志
  • Organizer: World Congress of Psychiatric Genetics
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2012-10-16
• [Presentation] 双極性障害のgenome-wide asso ciation study (GWAS) (2012)
  • Author(s): 池田匡志
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-29
  • Invited
• [Presentation] 双極性障害のgenome-wide association study (GWAS) (2012)
  • Author(s): 池田匡志
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2012-09-29
• [Presentation] 統合失調症と覚醒剤誘発性精神病の遺伝学的共通性 (2012)
  • Author(s): 池田匡志
  • Organizer: 日本精神神経学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-05-25