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Identification of rare risk variants for schizophrenia using target resequencing

Research Project

Project/Area Number 24689046
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Psychiatric science
Research InstitutionFujita Health University

Principal Investigator

IKEDA Masashi  藤田保健衛生大学, 医学部, 講師 (60424933)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Keywords臨床精神分子遺伝学 / 精神科遺伝学 / ゲノム / 脳神経疾患
Research Abstract

Several epidemiological studies suggests that the genetic risk has significant influence of susceptibility for schizophrenia. Therefore a large number of genetic studies targeting common variants has been carried out, however small number of the risk variants were discovered by such studies. With the progress of next generation sequencing methodology, detecting of rare risk variant is topic for schizophrenia genetics. In this study, we conducted case-control analysis of target resequencing (about 300 genes) and examined burden of rare variants (nonsense or insertion/deletion).
We found no significant enrichment between schizophrenia and controls, but detected trend for significance of over-representation in early-onset of schizophrenia.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (15 results)

All 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population2014

    • Author(s)
      Kajio Y, Kondo K, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N.
    • Journal Title

      J Hum Genet

      Volume: 59 Issue: 1 Pages: 54

    • DOI

      10.1038/jhg.2013.116

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia2013

    • Author(s)
      池田 匡志 他
    • Journal Title

      Neuropsychopharmacology

      Volume: 38 Issue: 10 Pages: 1864-1870

    • DOI

      10.1038/npp.2013.94

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of cognitive decline in schizophrenia.2013

    • Author(s)
      Hashimoto R, et al.
    • Journal Title

      Am J Psychiatry

      Volume: 170(6) Issue: 6 Pages: 683-4

    • DOI

      10.1176/appi.ajp.2013.12091228

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population2013

    • Author(s)
      Ikeda M, Aleksic B, Yamada K, Iwayama-Shigeno Y, Matsuo K, Numata S, Watanabe Y, Ohnuma T, Kaneko T, Fukuo Y, Okochi T, Toyota T, Hattori E, Shimodera S, Itakura M, Nunokawa A, Shibata N, Tanaka H, Yoneda H, Arai H, Someya T, Ohmori T, Yoshikawa T, Ozaki N, Iwata N
    • Journal Title

      Mol Psychiatry

      Volume: 18(6) Issue: 6 Pages: 636-638

    • DOI

      10.1038/mp.2012.74

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implication of a rare deletion at distal 16p11.2 in schizophrenia2013

    • Author(s)
      Guha S, Rees E, Darvasi A, Ivanov D, Ikeda M, Bergen SE, Magnusson PK, Cormican P, Morris D, Gill M, Cichon S, Rosenfeld JA, Lee A, Gregersen PK, Kane JM, Malhotra AK, Rietschel M, Nothen MM, Degenhardt F, Priebe L, Breuer R, Strohmaier J, Ruderfer DM, Moran JL, Chambert KD, Sanders AR, Shi J, Kendler K, Riley B, O'Neill T, Walsh D, Malhotra D, Corvin A, Purcell S, Sklar P, Iwata N, Hultman CM, Sullivan PF, Sebat J, McCarthy S, Gejman PV, Levinson DF, Owen MJ, O'Donovan MC, Lencz T and Kirov G
    • Journal Title

      JAMA Psychiatry

      Volume: 70(3) Issue: 3 Pages: 253-60

    • DOI

      10.1001/2013.jamapsychiatry.71

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder2013

    • Author(s)
      Lencz T, Guha S, Liu C, Rosenfeld J, Mukherjee S, Derosse P, John M, Cheng L, Zhang C, Badner JA, Ikeda M, Iwata N, Cichon S, Rietschel M, Nothen MM, Cheng AT, Hodgkinson C, Yuan Q, Kane JM, Lee AT, Pisante A, Gregersen PK, Pe'er I, Malhotra AK, Goldman D and Darvasi A
    • Journal Title

      Nat Commun

      Volume: 4 Issue: 1 Pages: 2739-2739

    • DOI

      10.1038/ncomms3739

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder2013

    • Author(s)
      Esaki K, Kondo K, Hatano M, Saito T, Kishi T, Umene-Nakano W, Yoshimura R, Nakamura J, Ozaki N, Ikeda M and Iwata N
    • Journal Title

      Journal of human genetics

      Volume: 58(8) Issue: 8 Pages: 568-9

    • DOI

      10.1038/jhg.2013.52

    • NAID

      10031195290

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of atypical psychosis2013

    • Author(s)
      金沢 徹文 他
    • Journal Title

      American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

      Volume: 162 Issue: 7 Pages: 679-686

    • DOI

      10.1002/ajmg.b.32164

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study2013

    • Author(s)
      Kondo K, Ikeda M, Kajio Y, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e70964-e70964

    • DOI

      10.1371/journal.pone.0070964

    • URL

      https://pure.teikyo.jp/en/publications/e96a4517-a758-4417-a82d-8d920315d238

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders2012

    • Author(s)
      Matsunaga S, Ikeda M, Kishi T, Fukuo Y, Aleksic B, Yoshimura R, Okochi T, Yamanouchi Y, Kinoshita Y, Kawashima K, Umene-Nakano W, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Nakamura J, Ozaki N, Kitajima T, Iwata N
    • Journal Title

      Neurosci Lett

      Volume: 529 Issue: 1 Pages: 66

    • DOI

      10.1016/j.neulet.2012.08.070

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Shared risk between Methamp hetamine-induced psychosis and schizop hrenia2012

    • Author(s)
      池田匡志
    • Organizer
      World Congress of Psychiatric Ge netics
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2012-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Shared risk between Methamphetamine-induced psychosis and schizop hrenia2012

    • Author(s)
      池田匡志
    • Organizer
      World Congress of Psychiatric Genetics
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      2012-10-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] 双極性障害のgenome-wide asso ciation study (GWAS)2012

    • Author(s)
      池田匡志
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-29
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 双極性障害のgenome-wide association study (GWAS)2012

    • Author(s)
      池田匡志
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2012-09-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症と覚醒剤誘発性精神病の遺伝学的共通性2012

    • Author(s)
      池田匡志
    • Organizer
      日本精神神経学会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-25
    • Related Report
      2013 Final Research Report 2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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