| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Disruption of atherosclerotic plaques and the following thrombus formation is currently recognized as the primary mechanism of myocardial and cerebral infarctions. In this study, we compared PET imaging agents, [18F]FDG, [18F]FMISO, [18F]NaF, [11C]Choline, [11C]PK11195, using WHHL rabbit in same animals.
[18F]FDG accumulated into atherogenic M1 macrophges, but SN ratio was not very high. [18F]NaF showed the highest SN ratio, and small region was clearly visualized. Macrophage accumulation was seen with [11C]Choline, however, the signal from the heart and liver disturbed the detection with PET. [11C]PK11195 distribution was different from [18F]FDG, and in some animals, the plaque was not detected due to the high heart uptake. [18F]FMISO did not show significant signal around the atherosclerotic regions.
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