PET imaging probes for detection and evaluation of atherosclerotic plaques
| Project/Area Number |
24689049
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University (2015)
Hamamatsu University School of Medicine (2012-2014) |
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Principal Investigator |
OGAWA Mikako 北海道大学, 薬学研究科(研究院), 教授 (20344351)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | PET / 動脈硬化 / 不安定プラーク / 分子イメージング / MRI |
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| Outline of Final Research Achievements |
Disruption of atherosclerotic plaques and the following thrombus formation is currently recognized as the primary mechanism of myocardial and cerebral infarctions. In this study, we compared PET imaging agents, [18F]FDG, [18F]FMISO, [18F]NaF, [11C]Choline, [11C]PK11195, using WHHL rabbit in same animals.
[18F]FDG accumulated into atherogenic M1 macrophges, but SN ratio was not very high. [18F]NaF showed the highest SN ratio, and small region was clearly visualized. Macrophage accumulation was seen with [11C]Choline, however, the signal from the heart and liver disturbed the detection with PET. [11C]PK11195 distribution was different from [18F]FDG, and in some animals, the plaque was not detected due to the high heart uptake. [18F]FMISO did not show significant signal around the atherosclerotic regions.
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [(11)C]CB184 and [ (11)C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ (11)C](R)-PK11195.2015
Author(s)
Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H.
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Journal Title
Ann Nucl Med
Volume: 29
Issue: 4
Pages: 325-335
DOI
Related Report
Peer Reviewed
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[Journal Article] Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm2014
Author(s)
Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, Zaima N, Tanaka H, Inuzuka K, Yamamoto N, Setou M, Sato K, Konno H, Unno N
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Journal Title
PLoS One
Volume: 9
Issue: 3
Pages: e89830-e89830
DOI
Related Report
Peer Reviewed / Open Access
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