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Ligand-incorporated Polymeric Micelles for Advanced Therapeutic Strategies of Arteriosclerosis

Research Project

Project/Area Number 24689051
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field General surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Miura Yutaka  東京大学, 医学(系)研究科(研究院), 助教 (40557980)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsドラッグデリバリー / ナノ材料 / 動脈硬化症 / ドラックデリバリー
Outline of Final Research Achievements

Here we evaluated the specific drug delivery against atherosclerotic lesions and abdominal aortic aneurysms (AAA). For intimal lesions, Cy5-labeled polymeric micelles and vesicles, with diameters of 40, 100, or 200 nm (PICs-40, PICs-100, and PICs-200, respectively) were intravenously administered to rats after injury to the carotid artery using a balloon catheter. High accumulation of PICs-40 in the induced neointima was confirmed by in vivo imaging, while the accumulation of PICs-100 and PICs-200 was limited, indicating that the size of nanocarriers is a crucial factor for efficient delivery. Similar strategy was applied for AAA, and high accumulation of PICs-100 was confirmed in vivo. Furthermore, drug-incorporated polymeric micelles with diameters similar to that of PICs-40 and PICs-100 showed significant curative effects vs rats with induced neointima and AAA. We consider that this nanocarrier-based drug delivery system could be utilized for the treatment of atherosclerosis.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(75 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Journal Article] Crgd-Installed Polymeric Micelles Loading Platinum Anticancer Drugs Enable Cooperative Treatment against Lymph Node Metastasis2016

    • Author(s)
      Jun Makino, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Ming Wang, Hiroaki Kinoh, Yuki Mochida, Nobuhiro Nishiyama, Kazunori Kataoka
    • Journal Title

      J Control Release

      Volume: 220 PartB Pages: 783-791

    • DOI
      10.1016/j.jconrel.2015.10.017
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi2016

    • Author(s)
      M. Tangsangasaksri, K. Miyata, et al
    • Journal Title

      Biomacromolecules

      Volume: 17 Pages: 246-255

    • DOI
      10.1021/acs.biomac.5b01334
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intracellular delivery of charge-converted monoclonal antibodies by combinatorial design of block/homo polyion complex micelles2016

    • Author(s)
      Ahram Kim, Yutaka Miura, Takehiko Ishii, Omer F. Mutaf, Nobuhiro Nishiyama, Horacio Cabral, Kazunori Kataoka
    • Journal Title

      Biomacromolecules

      Volume: 17 Pages: 446-453

    • DOI
      10.1021/acs.biomac.5b01335
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Systemic targeting of lymph node metastasis through the blood vascular system by using size-controlled nanocarriers2015

    • Author(s)
      H. Cabral, J. Makino, Y. Matsumoto, P. Mi, H. Wu, T. Nomoto, K. Toh, N. Yamada, Y. Higuchi, S. Konishi, M.R. Kano, H. Nishihara, Y. Miura, N. Nishiyama, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: Article ASAP Pages: 4957-4967

    • DOI
      10.1021/nn5070259
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas2015

    • Author(s)
      Kawamura W, Miura Y, Kokuryo D, Toh K, Yamada N, Nomoto T, Matsumoto Y, Sueyoshi D, Liu X, Aoki I, Kano MR, Nishiyama N, Saga T, Kishimura A, Kataoka K
    • Journal Title

      Sci. Technol. Adv. Mater.

      Volume: 16 Pages: 035004-035004

    • DOI
      10.1088/1468-6996/16/3/035004
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Polymeric micelle platform for multimodal tomographic imaging to detect scirrhous gastric cancer2015

    • Author(s)
      Yutaka Miura, Atsushi B. Tsuji, Aya Sugyo, Hitomi Sudo, Ichio Aoki, Masayuki Inubushi, Masakazu Yashiro, Kosei Hirakawa, Horacio Cabral, Nobuhiro Nishiyama, Tsuneo Saga, Kazunori Kataoka
    • Journal Title

      ACS Biomater. Sci. Eng.

      Volume: 1 Pages: 1067-1076

    • DOI
      10.1021/acsbiomaterials.5b00142
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 薬剤デリバリーのための高分子ナノキャリアの開発とサイズ効果2015

    • Author(s)
      三浦裕、オラシオ・カブラル、片岡一則
    • Journal Title

      バイオマテリアル-生体材料-特集:微粒子バイオマテリアル

      Volume: 33 Pages: 296-301

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation.2015

    • Author(s)
      H. Wu, H. Cabral, K. Toh, P. Mi, Y.-C. Chen, Y. Matsumoto, N. Yamada, X. Liu, H. Kinoh, Y. Miura, M. R. Kano, H. Nishihara, N. Nishiyama, K. Kataoka
    • Journal Title

      J Control Release

      Volume: 189 Pages: 1-10

    • DOI
      10.1016/j.jconrel.2014.06.018
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer.2015

    • Author(s)
      J. -Y. Ahn, Y. Miura, N. Yamada, T. Chida, X. Liu, A. Kim, R. Sato, R. Tsumura, Y. Koga, M. Yasunaga, N. Nishiyama, Y. Matsumura, H. Cabral, K. Kataoka
    • Journal Title

      Biomaterials

      Volume: 39 Pages: 23-30

    • DOI
      10.1016/j.biomaterials.2014.10.069
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor.2014

    • Author(s)
      Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 8 Pages: 6724-6738

    • DOI
      10.1021/nn500498t
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy2014

    • Author(s)
      S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, H. Kinoh, Y. Miura, N. Nishiyama, K. Kataoka
    • Journal Title

      Journal of Controlled Release

      Volume: 188 Pages: 67-77

    • DOI
      10.1016/j.jconrel.2014.05.048
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Actively-targeted polygon complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors2014

    • Author(s)
      Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka
    • Journal Title

      Biomaterials

      Volume: 35 Pages: 7887-7895

    • DOI
      10.1016/j.biomaterials.2014.05.041
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Light-Induced Cytosolic Activation of Reduction-Sensitive Camptothecin-Loaded Polymeric Micelles for Spatiotemporally Controlled in Vivo Chemotherapy2014

    • Author(s)
      H.-C. Yen, H. Cabral, P. Mi, K. Toh, Y. Matsumoto, X. Liu, H. Koori, A. Kim, K. Miyazaki, Y. Miura, N. Nishiyama, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 8 Pages: 11591-11602

    • DOI
      10.1021/nn504836s
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors2013

    • Author(s)
      S. Deshayes, N. Nishiyama, et al.
    • Journal Title

      Journal of the American Chemical Society

      Volume: 135 Pages: 15501-15507

    • DOI
      10.1021/ja406406h
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier2013

    • Author(s)
      Y. Miura, N. Nishiyama, et al.
    • Journal Title

      ACS Nano

      Volume: 7 Pages: 8353-8592

    • DOI
      10.1021/nn402662d
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcript ion Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1αin a p53-Independent Manner2013

    • Author(s)
      S. Wu, N. Nishiyama, et al.
    • Journal Title

      Cancer research

      Volume: 73 Pages: 1787-1799

    • DOI
      10.1158/0008-5472.can-12-0366
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Secondary structures in the core of platinum-loaded polymeric micelles improve tumor-targeted drug delivery2016

    • Author(s)
      Y. Mochida, H. Cabral, Y. Miura, A. Francesco, K. Osada, N. Nishiyama, K. Kataoka
    • Organizer
      2016 international symposium on nanobiotechnology
    • Place of Presentation
      California (USA)
    • Year and Date
      2016-02-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cyclic RGD peptide-decorated polymeric micelles for overcoming refractory cancer with enhanced stemness2015

    • Author(s)
      Y. Mochida, M. Wang, Y. Miura, H. Cabral, N. Nishiyama, K. Kataoka
    • Organizer
      第2回COINS国際シンポジウム "スマートヘルスケアを実現するイノベーションの最前線"
    • Place of Presentation
      東京大学伊東国際学術研究センター (東京都、文京区)
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ligand installed polymeric micelles for cooperative treatment of lymph node metastasis2015

    • Author(s)
      J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, M. Wang, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka
    • Organizer
      第2回COINS国際シンポジウム "スマートヘルスケアを実現するイノベーションの最前線"
    • Place of Presentation
      東京大学伊東国際学術研究センター (東京都、文京区)
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of phenylboronic acid-installed polymeric micelles for sialic acid targeting2015

    • Author(s)
      A. Tanabe, Y. Miura, H. Cabral, K. Kataoka
    • Organizer
      第2回COINS国際シンポジウム "スマートヘルスケアを実現するイノベーションの最前線"
    • Place of Presentation
      東京大学伊東国際学術研究センター (東京都、文京区)
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Higher-order structure of poly(glutamic acid) enhances drug delivery performance of anticancer platinum-loaded polymeric micelles2015

    • Author(s)
      Y. Mochida, H. Cabral、Y. Miura、A. Francesco、K. Osada、N. Nishiyama、K. Kataoka
    • Organizer
      The 11th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2015)
    • Place of Presentation
      Pacifico Yokohama (Kanagawa, Yokohama)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 白金制がん剤を内包する高分子ミセルの安定性及び機能を決定する内核高次構造2015

    • Author(s)
      持田祐希、H. Cabral、三浦裕、F. Albertini、長田健介、西山伸宏、片岡一則
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス (宮城県、仙台市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腫瘍に過剰発現するシアル酸を標的可能なフェニルボロン酸導入高分子ミセルの開発2015

    • Author(s)
      田辺亜弥、三浦裕、H. Cabral、片岡一則
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター (北海道、札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 環状RGDペプチドを搭載した白金錯体制がん剤内包ミセルのがん幹細胞治療への展開2015

    • Author(s)
      持田祐希、M. Wang、H. Cabral、三浦裕、西山伸宏、片岡一則
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター (北海道、札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] グルコースリガンドを有する高分子ミセル型DDS製剤の開発と難治がんへの治療効果2015

    • Author(s)
      鈴木利洋、三浦裕、石井武彦、土橋賢司、西山伸宏、佐谷秀行、片岡一則
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター (北海道、札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内膜肥厚に対するエピルビシン内包高分子ミセルの応用2015

    • Author(s)
      三浦裕、谷口良輔、片岡一則、小山博之
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター (北海道、札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation2014

    • Author(s)
      H. Wu, H. Cabral, K. Toh, P. Mi, Y. Matsumoto, J. -Y. Ahn, H. Kinoh, N. Nishiyama, Y. Miura, K. Kataoka
    • Organizer
      The 10th International Polymer Conference IPC2014
    • Place of Presentation
      International Congress Center, Tsukuba, Ibaraki
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Systemic targeting of lymph node metastasis by controlled design of drug-loaded polymeric micelles2014

    • Author(s)
      J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, H. Kinoh, N. Nishiyama, K. Kataoka
    • Organizer
      12th International Nanomedicine and Drug Delivery Symposium (NanoDDS'14)
    • Place of Presentation
      UNC Eshelman School of Pharmacy and Duke University, North Carolina, USA
    • Year and Date
      2014-10-06 – 2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of a specific targeting system for pancreatic tumors utilizing antibody conjugated Pt-loaded micelles2014

    • Author(s)
      J. -Y. Ahn, N. Yamada, A. Kim, T. Chida, Y. Miura, H. Cabral, Y. Matsumura, N. Nishiyama, K. Kataoka
    • Organizer
      41st Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      The Hilton Chicago, Chicago, Illinois, USA
    • Year and Date
      2014-07-13 – 2014-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of a glutathione sensitive polymeric micelles for the delivery of campothecin to solid tumors2014

    • Author(s)
      H.-C. Yen, H. Cabral, H. Koori, Y. Miura, P. Mi, A. Kim, N. Nishiyama, K. Kataoka
    • Organizer
      41st Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      The Hilton Chicago, Chicago, Illinois, USA
    • Year and Date
      2014-07-13 – 2014-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Efficient intracellular delivery of monoclonal antibodies into the living cells by charge-conversional polyionic complex micelles2014

    • Author(s)
      A. Kim, Y. Miura, T. Ishii, K. Kataoka
    • Organizer
      41st Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      The Hilton Chicago, Chicago, Illinois, USA
    • Year and Date
      2014-07-13 – 2014-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ligand-linked polymeric micelles for targeted delivery of platinum anti-cancer drug into malignant tumor2014

    • Author(s)
      Y. Miura, K. Kataoka
    • Organizer
      The Drug Discovery & Therapy World Congress 2014
    • Place of Presentation
      John B. Hynes Veterans Mmemorial Convention Center, Boston, Massachusetts, USA
    • Year and Date
      2014-06-16 – 2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Sub- 100 Nm size of polymeric micelles incorporating platinum anticancer drugs mediates the targeting to lymph node metastasis after systemic injection2014

    • Author(s)
      H. Cabral, P. Mi, H. Wu, J. Makino, Y. Matsumoto, Y. Miura, K. Toh, N. Nishiyama, N. Yamada, K. Kataoka
    • Organizer
      FIRST合同国際シンポジウム 難治がんを克服する―次世代の診断、治療が描く未来 Overcoming Intractable Cancer- a new path to the future
    • Place of Presentation
      伊藤国際学術研究センター、文京区、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Growth inhibition of tumor by ligand-mediated drug delivery system2014

    • Author(s)
      Y. Miura, H. Cabral, N. Nishiyama, K. Kataoka
    • Organizer
      FIRST合同国際シンポジウム 難治がんを克服する―次世代の診断、治療が描く未来 Overcoming Intractable Cancer- a new path to the future
    • Place of Presentation
      伊藤国際学術研究センター、文京区、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Systemically injected polymeric micelles can inhibit the growth of lymph node metastasis2013

    • Author(s)
      H. Cabral, J. Makino, Y. Matsumoto, Y. Miura, M. Kano, N. Nishiyama, K. Kataoka
    • Organizer
      FRONTIERS2013 - Joint EPFL/University of Tokyo Symposium on "Frontiers in Nanomedicine and Imaging"
    • Place of Presentation
      Swiss Federal Institute of Technology, Lausanne, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of platinum incorporated polymeric micelle with peptide-ligand2013

    • Author(s)
      Y. Miura, N. Yamada, N. Nishiyama, K. Kataoka
    • Organizer
      FRONTIERS2013 - Joint EPFL/University of Tokyo Symposium on "Frontiers in Nanomedicine and Imaging"
    • Place of Presentation
      Swiss Federal Institute of Technology, Lausanne, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeting cancer stem cells with platinum anti-cancer drug-incorporated polymeric micelles2013

    • Author(s)
      M. Wang, Y. Miura, H. Cabral, N. Nishiyama, H. Saya K. Kazunori
    • Organizer
      European Cancer Congress 2013
    • Place of Presentation
      Avenue E. Mounier 83 B-1200 Brussels, Belgium
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimization of c-RGD peptide on the surface of polymeric micelles, incorporating epirubicin, for superior antitumor efficacy2013

    • Author(s)
      S. Quader, J. Makino, H. Cabral, T. Ishii, Y. Miura, N. Nishiyama, K. Kataoka
    • Organizer
      The 13th Pacific Polymer Conference
    • Place of Presentation
      Grand Hi-Lai Hotel Arena Branch, Kaohsiung, Taiwan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intravital microscopy for DDS evaluation and development2013

    • Author(s)
      Y. Matsumoto, T. Nomoto, K. Toh, K. Miyano, H. Cabral, M. Murakami, R. J. Christie, T. A. Tockary, K. Osada, Y. Miura, N. Nishiyama, T. Yamasoba, K. Kataoka
    • Organizer
      The 12th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      Lahaina, Maui, Hawaii
    • Related Report
      2013 Annual Research Report
  • [Presentation] pH応答性エピルビシン内包高分子ミセル(K-912(NC-6300))のヒト乳がん移植モデルマウスに対する治療効果2013

    • Author(s)
      千田司、三浦裕、西山伸宏、片岡一則、加藤泰己、奥村睦男、稲木敏男
    • Organizer
      第28年会 日本薬剤学会
    • Place of Presentation
      ウインクあいち、名古屋市、愛知県
    • Related Report
      2013 Annual Research Report
  • [Presentation] ペプチドリガンドを有するプラチナ制がん剤内包高分子型ミセルの開発と機能評価2013

    • Author(s)
      三浦裕、山田直生、西山伸宏、片岡一則
    • Organizer
      第62回高分子年次大会
    • Place of Presentation
      京都国際会館、京都市、京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] リガンド導入ミセルの粒径に依存した抗腫瘍効果の研究2013

    • Author(s)
      山田直生、三浦裕、アン ジュヨン、カブラル オラシオ、西山伸宏、片岡一則
    • Organizer
      第62回高分子年次大会
    • Place of Presentation
      京都国際会館、京都市、京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of antibody conjugated polymeric micelle for enhanced targeting drug delivery system2013

    • Author(s)
      J. -Y. Ahn, Y. Miura, H. Uchida, N. Yamada, H. Cabral, N. Nishiyama, K. Kataoka
    • Organizer
      第62回高分子年次大会
    • Place of Presentation
      京都国際会館、京都市、京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポリイオンコンプレックス型ベシクルによる腹部大動脈瘤の蛍光イメージング2013

    • Author(s)
      三浦裕、安楽泰孝、赤井淳、岸村顕広、西山伸宏、小山博之、片岡一則
    • Organizer
      第62回高分子年次大会
    • Place of Presentation
      京都国際会館、京都市、京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] pH応答性エピルビシン内包高分子ミセルの特性評価並びに制がん活性に関する検討2013

    • Author(s)
      千田司、三浦裕、西山伸宏、片岡一則、加藤泰己、奥村睦男、稲木敏男
    • Organizer
      第62回高分子年次大会
    • Place of Presentation
      京都国際会館、京都市、京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of antibody conjugated polymeric micelle for targeted drug delivery system2013

    • Author(s)
      J. -Y. Ahn, Y. Miura, N. Yamada, A. Kim, H. Uchida, H. Cabral, N. Nishiyama, K. Kataoka
    • Organizer
      第13回東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学本郷キャンパス伊藤国際学術研究センター、文京区、東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeting cancer stem cells with platinum anti-cancer drug-incorporated polymeric micelles2013

    • Author(s)
      M. Wang, 三浦裕, H. Cabral, 西山伸宏、片岡一則
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都テルサ、京都市、京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下咽頭癌を標的としたDACHPt内包高分子ミセルを用いたドラッグデリバリーシステムの開発2013

    • Author(s)
      木村美和子, H. Cabral, 三浦裕, 狩野光伸, 西山伸宏, 片岡一則
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都テルサ、京都市、京都府
    • Related Report
      2013 Annual Research Report
  • [Presentation] サイズとリガンド導入率の調整が可能なポリイオンコンプレックス型ベシクル (PICsome) の構築と機能評価2013

    • Author(s)
      川村渉、安楽泰孝、岸村顕広、三浦裕、片岡一則
    • Organizer
      第62回高分子学会討論会
    • Place of Presentation
      金沢大学角間キャンパス、金沢、石川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 粒径とリガンド導入率を精密制御した白金制がん剤内包ミセルの合成ならびに脳腫瘍に対する治療効果2013

    • Author(s)
      山田直生、三浦裕、J. -Y. Ahn、H. Cabral、西山伸宏、片岡一則
    • Organizer
      第62回高分子学会討論会
    • Place of Presentation
      金沢大学角間キャンパス、金沢、石川
    • Related Report
      2013 Annual Research Report
  • [Presentation] A study on the design of glutathione sensitive polymeric micelles for anticancer drugs2013

    • Author(s)
      H. Yen, H. Cabral, H. Koori, Y. Miura, P. Mi, A. Kim, N. Nishiyama, K. Kataoka
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、江戸川、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 治療抵抗性がん治療に向けたリガンド導入高分子ミセルの合成2013

    • Author(s)
      鈴木利洋、石井武彦、三浦裕、西山伸宏、片岡一則
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、江戸川、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗体結合高分子ミセルの開発とアクティブターゲティング DDS への応用2013

    • Author(s)
      J. -Y. Ahn、三浦裕、山田直生、K. Ahram、松村保広、西山伸宏、片岡一則
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、江戸川、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Disulfide crosslinked charge-conversional polymeric micelles for the efficient intracellular delivery of monoclonal antibodies2013

    • Author(s)
      K. Ahram、三浦裕、石井武彦、西山伸宏、片岡一則
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、江戸川、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] pH 応答性エピルビシン内包高分子ミセルの特性評価並びに制がん活性に関する検討2013

    • Author(s)
      千田司、三浦裕、西山伸宏、片岡一則、加藤泰己、奥村睦男、稲木敏男
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀、江戸川、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 環状RGDリガンドを有するプラチナ制がん剤内包ミセルの開発と悪性腫瘍への展開2013

    • Author(s)
      三浦裕、山田直生、西山伸宏、片岡一則
    • Organizer
      第22回ポリマー材料フォーラム
    • Place of Presentation
      タワーホール船堀、江戸川、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Size effect on the antitumor efficacy of cRGD-installed polymeric micelles against brain tumor2013

    • Author(s)
      Naoki Yamada, Yutaka Miura, 他3名
    • Organizer
      ICBS2013 (2nd Internatlonal Conference of Biomaterials Science in Tsukuba)
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Secondary structure of PEG-b-poly (glutamic acid) copolymer determines the drug delivery efficiency of cistplatin-loaded polymeric micelles2013

    • Author(s)
      Yuki Mochida, Yutaka Miura, 他5名
    • Organizer
      16th International Symposium on RECENT ADVANCES IN DRUG DELIVERY SYSTEMS
    • Place of Presentation
      Salt Lake City (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Preparation of antibody introduced micelle consist of well defined end-functionalized poly (ethylene oxide)-b-poly (amino acid)2012

    • Author(s)
      Jooyeon Ahn; Yutaka Miura, 他4名
    • Organizer
      The 9th International Polymer Conference (IPC2012)
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization and evaluation of the charge-conversional polyionic complexmicelies incorporat ing monoclonal antibodies2012

    • Author(s)
      Ahram Kim, Yutaka Miura, 他5名
    • Organizer
      The 9th International Polymer Conference (IPC2012)
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 悪性脳腫瘍を標的としたリガンド介在型ドラッグデリバリ-システムの開発2012

    • Author(s)
      三浦裕、Horacio Cabral.西山伸宏、片岡一則
    • Organizer
      第28回日本DDS学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Preparation and pH-responsive property of the charge-conversional polyionic complex micelles incorporating immunoreactive monoclonal antibodies2012

    • Author(s)
      Ahram Kim, Yutaka Miura, 他5名
    • Organizer
      The 61st Symposium on Macromolecules
    • Place of Presentation
      名古屋工業大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Preparation and Evalualution of the Cnarge-Conversional Protein Incorporated Polyionic Complex Micelles2012

    • Author(s)
      Ahram Kim, Yutaka Miura, 他5名
    • Organizer
      SPSJ Annual meeting
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Formation and sustained-dissociation of antitumor platinum-loaded micelles regulated by secondary structure of poly (amino acids) in their core2012

    • Author(s)
      Yuki Mochida, Yutaka Miura, 他5名
    • Organizer
      9th World Biomaterials Congress
    • Place of Presentation
      Chengdu (China)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 白金錯体制がん剤内包ミセルのコア高次構造が形態及び薬剤機能に及ぼす影響2012

    • Author(s)
      持田祐希、三浦裕, 他5名
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] αヘリックス構造形成に基つくPEG-ポリグルタミン酸ブロック共重合体/制がん剤ダハプラチン内包高分子ミセルの機能向上2012

    • Author(s)
      持田祐希、三浦裕, 他5名
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋工業大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structure and enhanced pharmacokinetics of antitumor platinum-loaded micelles regulated by secondary structure in their core2012

    • Author(s)
      Vuki Mochida, Yutaka Miura, 他5名
    • Organizer
      The 9th SPSJ Iuternational Polymer Conference
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Book] The Frontiers in Life Sciencesシリーズ 生命科学から創薬へのイノベーション 第18章 ドラッグデリバリー2014

    • Author(s)
      三浦裕、片岡一則
    • Total Pages
      8
    • Publisher
      南山堂
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学片岡研究室

    • URL
      http://www.bmw.t.u-tokyo.ac.jp/
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 東京大学片岡研究室

    • URL
      http://www.bmw.t.u-tokyo.ac.jp/
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL
      http://www.bmw.t.u-tokyo.ac.jp/
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗Tissue Factorモノクローナル抗体2014

    • Inventor(s)
      片岡 一則, 西山 伸宏, 三浦 裕, 他8名
    • Industrial Property Rights Holder
      片岡 一則, 西山 伸宏, 三浦 裕, 他8名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-018586
    • Filing Date
      2014-02-03
    • Application Year
      2014
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 環状RGD配列含有ペプチドを含む抗癌剤2013

    • Inventor(s)
      片岡 一則, 西山 伸宏, 三浦 裕
    • Industrial Property Rights Holder
      片岡 一則, 西山 伸宏, 三浦 裕
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-29
    • Application Year
      2013
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 高分子ナノ粒子複合体、及びそれを含むMRI造影用組成物2013

    • Inventor(s)
      片岡 一則, 西山 伸宏, 三浦 裕, 他6名
    • Industrial Property Rights Holder
      片岡 一則, 西山 伸宏, 三浦 裕, 他6名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-173866
    • Filing Date
      2013-08-23
    • Application Year
      2013
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 環状RGD配列含有ペプチドを含む抗癌剤2012

    • Inventor(s)
      片岡一則、西山伸宏、三浦裕
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2012-261225
    • Filing Date
      2012-11-29
    • Application Year
      2012
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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