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LGR5 splicing variant in intestinal epithelial cells

Research Project

Project/Area Number 24689054
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Digestive surgery
Research InstitutionOsaka University

Principal Investigator

NISHIMURA Junichi  大阪大学, 医学(系)研究科(研究院), 助教 (20379209)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
KeywordsLGR5 / スプライシングバリアント / 腸管上皮細胞 / LGR5 splicing varinat / 腸管上皮幹細胞
Research Abstract

LGR5 splicing variants were expressed in the epithelium of ileum, ascending colon, transverse colon, sigmoid colon, and rectum. HEK293 cells which were overexpressed total LGR5 or splicing variant LGR5 grows slowly in splicing variant overexpressed cells. Wnt signal was activated in splicing variant overexpressed cells. Splicing variant LGR5s were expressed in the upper of CBC using in situ hybridization assay.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (2 results)

All 2014 2012

All Presentation (2 results)

  • [Presentation] PTBP1は大腸癌において、CD44、PKMのバリアントをコントロールする2014

    • Author(s)
      西村潤一、高橋秀和、原口直紹、植村守、畑泰司、竹政伊知朗、水島恒和、山本浩文、土岐祐一郎、森正樹
    • Organizer
      第114回日本外科学会的学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Leucine-rich repeat-containing G-protein-coupled receptor5 (LGR5)のヒト腸管における発現解析2012

    • Author(s)
      浜部敦史、山本浩文、西村潤一、太田勝也、高橋秀和、植村守、原口直紹、竹政伊知朗、水島恒和、池田正孝、関本貢嗣、石井秀始、土岐祐一郎、森正樹
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      徳島
    • Related Report
      2013 Final Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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