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Towards an integrated understandings of the inflammatory tissue remodeling in the pathogenesis of rheumatoid arthritis

Research Project

Project/Area Number 24689056
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Orthopaedic surgery
Research InstitutionNagoya City University (2016)
Kyoto University (2012-2015)

Principal Investigator

ASAGIRI Masataka  名古屋市立大学, 薬学研究科(研究院), 准教授 (20372435)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords関節リウマチ / 自己免疫 / 病理学 / 免疫学 / 炎症 / 組織破壊 / 組織再構築 / 骨代謝 / 自然免疫 / 組織変性
Outline of Final Research Achievements

Inflammatory bone destruction exceeds bone formation in the pathogenesis of rheumatoid arthritis (RA). In this study, we gained insights into the mechanism of RA bone destruction by elucidating a link in various organs in inflammation pathology. As a result, we clarified novel activation mechanisms of NFkB molecules (Nature Immunol 2012; Cell Reports 2012; Blood 2016); identified a subset of cells involved in inflammatory fibrosis (PNAS 2014); and elucidated the role of ion permeable channels and actin binding proteins in bone metabolism (Science Signaling 2016; Scientific Reports 2017).

Report

(3 results)
  • 2016 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (10 results)

All 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells2015

    • Author(s)
      Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 166 Issue: 2 Pages: 84-90

    • DOI

      10.1159/000371419

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice2015

    • Author(s)
      Tanabe K, Taura K, Koyama Y, Yamamoto G, Nishio T, Okuda Y, Nakamura K, Toriguchi K, Takemoto K, Yamanaka K, Iwaisako K, Seo S, Asagiri M, Hatano E, Uemoto S.
    • Journal Title

      Journal of Gastroenterology

      Volume: in press Issue: 10 Pages: 1054-1068

    • DOI

      10.1007/s00535-015-1054-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategies to Detect Hepatic Myofibroblasts in Liver Cirrhosis of Different Etiologies2014

    • Author(s)
      Iwaisako K, Taura K, Koyama Y, Takemoto K, Asagiri M.
    • Journal Title

      Current Pathobiology Reports

      Volume: 2 Issue: 4 Pages: 209-215

    • DOI

      10.1007/s40139-014-0057-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.2014

    • Author(s)
      Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 777-787

    • DOI

      10.1016/j.fob.2014.08.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Origin of myofiblasts in the fibrotic liver in mice2014

    • Author(s)
      K.Iwaisako, C.Jiang, M.Zhang, M.Cong, T.J.Moore-Morris, T.J.Park, X.Liu, J.Xu, P.Wang, Y-H.Paik, F.Meng, M.Asagiri, L.A.Murray, A.F.Hofmann, T.Iida, C.K.Glass, D.A.Brenner, T.Kisseleva
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 111 Issue: 32

    • DOI

      10.1073/pnas.1400062111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation2013

    • Author(s)
      Soeno Y, Fujita K, Kudo T, Asagiri M, Kakuta S, Taya Y, Shimazu Y, Sato K, Tanaka-Fujita R, Kubo S, Iwakura Y, Nakamura Y, Mori S, and Aoba T
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 8 Pages: e72105-e72105

    • DOI

      10.1371/journal.pone.0072105

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Involvement of regulated necrosis in the pathogenesis of drug-induced acute liver failure2015

    • Author(s)
      Takemoto K, Hatano E, Iwaisako K, Toriguchi K, Tanabe K, Taura K, Uemoto S, Asagiri M.
    • Organizer
      SOT 2015 (54th Annual Meeting and ToxExpo of the Society of Toxicology)
    • Place of Presentation
      San Diego Convention Center (San Diego, California, USA)
    • Year and Date
      2015-03-22 – 2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 薬剤性劇症肝炎の病態形成における制御性壊死の関与2014

    • Author(s)
      竹本研史,波多野悦朗,祝迫惠子,竹入雅敏,野間成人,鳥口寛,田邉和孝,瀬尾智,田浦康二朗,朝霧成挙,上本伸二
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館 (沖縄)
    • Year and Date
      2014-07-01 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学医学研究科 次世代免疫制御を目指す創薬医学融合拠点 朝霧研究グループ

    • URL

      http://www.ak.med.kyoto-u.ac.jp/group_research/asagiriG.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学医学研究科 次世代免疫制御を目指す創薬医学融合拠点 朝霧研究グループ

    • URL

      http://www.ak.med.kyoto-u.ac.jp/group_research/asagiriG.html

    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2023-03-23  

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