Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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Outline of Final Research Achievements |
Inflammatory bone destruction exceeds bone formation in the pathogenesis of rheumatoid arthritis (RA). In this study, we gained insights into the mechanism of RA bone destruction by elucidating a link in various organs in inflammation pathology. As a result, we clarified novel activation mechanisms of NFkB molecules (Nature Immunol 2012; Cell Reports 2012; Blood 2016); identified a subset of cells involved in inflammatory fibrosis (PNAS 2014); and elucidated the role of ion permeable channels and actin binding proteins in bone metabolism (Science Signaling 2016; Scientific Reports 2017).
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