| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
Exosomes from IL-1β stimulated synovial fibroblasts induce OA-like changes both in vitro and in ex vivo models. Exosomes represent a novel mechanism by which pathogenic signals are communicated among different cell types in OA-affected joints. Our observations suggest that not only established signaling molecules, such as cytokines and hormones, but also exosomes including microRNA, as mediators of communication among different joint cells and tissues play an important role in osteoarthritis pathogenesis as a new regulatory mechanism. Furthermore, exosomes including miRNAs from mesenchymal stem cells promote tissue repair from injury. These results may explain the mechanism of tissue repair, in addition to their secretion of cytokines, or growth factors and may be a new therapeutic tool.
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