Exosomes including microRNA as a new mediators of communication among joint cells in OA pathogenesis
| Project/Area Number |
24689057
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | microRNA / エクソソーム / 変形性関節症 / 組織再生 / 間葉系幹細胞 / マイクロRNA / 軟骨 / 滑膜 / 関節病態 / マイクロＲＮＡ |
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| Outline of Final Research Achievements |
Exosomes from IL-1β stimulated synovial fibroblasts induce OA-like changes both in vitro and in ex vivo models. Exosomes represent a novel mechanism by which pathogenic signals are communicated among different cell types in OA-affected joints. Our observations suggest that not only established signaling molecules, such as cytokines and hormones, but also exosomes including microRNA, as mediators of communication among different joint cells and tissues play an important role in osteoarthritis pathogenesis as a new regulatory mechanism. Furthermore, exosomes including miRNAs from mesenchymal stem cells promote tissue repair from injury. These results may explain the mechanism of tissue repair, in addition to their secretion of cytokines, or growth factors and may be a new therapeutic tool.
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Report
(4 results)
Research Products
(18 results)
