| Project/Area Number |
24689060
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
OKADA Atsushi 名古屋市立大学, 医学(系)研究科(研究院), 講師 (70444966)
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| Research Collaborator |
KOHRI Kenjiro 名古屋市立大学, 大学院医学研究科, 学長 (30122047)
TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
HAMAMOTO Shuzo 名古屋市立大学, 大学院医学研究科, 助教 (80551267)
HIROSE Masahito 名古屋市立大学, 大学院医学研究科, 研究員 (70529172)
NIIMI Kazuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (70551274)
TAGUCHI Kazumi 名古屋市立大学, 大学院医学研究科, 研究員 (00595184)
FUJII Yasuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (30566229)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2012: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
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| Keywords | 尿路結石 / マクロファージ / op/opマウス / マルチプレックス解析 / 結晶貪食モデル / op/op / M-CSF / M2 / 結晶貪食 / 尿路結石症 / 結石消失現象 |
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| Outline of Final Research Achievements |
This study is aimed establish a technique to control the function of macrophages as a new prevention factor for kidney stone formation by positioning that the main constituent of the “stone elimination” phenomenon is "the kidney stone-phagocytosis activity" of Mφ, and we performed three following studies using an animal model, human specimen and culture model.
[1] We identified stone-preventive ability of M-CSF-derived M2-Mφ by increased stone formation in Mφ-deficient mice (op/op). [2] We showed the possibility that lower urinary IL-4 related in stone formation using multiplex analysis. [3] Using culture Mφ, we identified that the englobed COM crystals were revealed in lysosomes of Mφ with acidified environment and disappeared over time.
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