Research Project
Grant-in-Aid for Young Scientists (B)
The striatum neurons showed a residual firing response of slowly increasing duration when exposed to repetitive optogenetic photostimulation. The prolonged firing resumed after a 20 sec intermission. Residual depolarization with 8-sec half-life decay and firing prolongation by the repetitive photostimulation were observed through whole-cell patch clamp recordings. Our results indicate that striatal neurons hold their internal state in second-order timescale to count inputs cumulatively. Moreover, we proposed a new reinforcement learning model which was inspired by the prolonged firing.
All 2014 2013 2012 Other
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)
BioSystems
Volume: 118 Pages: 8-16
10.1016/j.biosystems.2014.01.006
Neuroscience Letters
Volume: 534 Pages: 182-187
10.1016/j.neulet.2012.11.058
