State-space remodeling in basal ganglia
| Project/Area Number |
24700200
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Perception information processing/Intelligent robotics
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| Research Institution | National Defense Medical College |
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Principal Investigator |
OHTA Hiroyuki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (20535190)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 強化学習 / 大脳基底核 / 線条体 / オプトジェネティクス / 側抑制 |
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| Outline of Final Research Achievements |
The striatum neurons showed a residual firing response of slowly increasing duration when exposed to repetitive optogenetic photostimulation. The prolonged firing resumed after a 20 sec intermission. Residual depolarization with 8-sec half-life decay and firing prolongation by the repetitive photostimulation were observed through whole-cell patch clamp recordings. Our results indicate that striatal neurons hold their internal state in second-order timescale to count inputs cumulatively. Moreover, we proposed a new reinforcement learning model which was inspired by the prolonged firing.
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Report
(3 results)
Research Products
(7 results)
