• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of C-index-based survival tree and its application to biomedical research

Research Project

Project/Area Number 24700276
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Statistical science
Research InstitutionOsaka University

Principal Investigator

HAYASHI Kenichi  大阪大学, 医学(系)研究科(研究院), 助教 (70617274)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords医学統計学 / 生存時間データ / C-index / 二重打ち切りデータ / Decision Tree / クロスバリデーション / C統計量
Outline of Final Research Achievements

This project investigated a concordance probability for time-to-event data called the C-index and its applicability to Survival Tree. The C-index can be seen as an extension of the area under the ROC curve for binary data. However, the existence of censored individuals causes a bias in estimating the C-index. We proposed some estimators for the C-index which reduce the bias, and demonstrated their superiority to the existing estimators via numerical experiments.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (11 results)

  • [Journal Article] Effects of unlabeled data on classification error in normal discriminant analysis2014

    • Author(s)
      Keiji Takai, Kenichi Hayashi
    • Journal Title

      Journal of Statistical Planning and Inference

      Volume: 147 Pages: 66-83

    • DOI

      10.1016/j.jspi.2013.11.004

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sample size determination in group-sequential clinical trials with two co-primary endpoints2014

    • Author(s)
      Asakura, K., Hamasaki, T., Sugimoto, T., Hayashi, K., Evans, S., Sozu T
    • Journal Title

      Statistics in Medicine

      Volume: (First published online) Issue: 17 Pages: 2897-2913

    • DOI

      10.1002/sim.6154

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Finite-sample analysis of impacts of unlabelled data and their labelling mechanisms in linear discriminant analysis2014

    • Author(s)
      Kenichi Hayashi, Keiji Takai
    • Journal Title

      Communications in Statistics -Simulation and Computation

      Volume: - Issue: 1 Pages: 184-203

    • DOI

      10.1080/03610918.2014.957847

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A boosting method with asymmetric mislabeling probabilities which depend on covariates2012

    • Author(s)
      Kenichi Hayashi
    • Journal Title

      Computational Statistics

      Volume: 27 Issue: 2 Pages: 203-218

    • DOI

      10.1007/s00180-011-0250-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of the Variance for the Maximum Likelihood Estimates in Normal Mixture Models and Normal Hidden Markov Models2011

    • Author(s)
      Masanari Iida and Naoto Niki
    • Journal Title

      Journal of the Japanese Society of Computational Statistics

      Volume: 24 Issue: 1 Pages: 39-66

    • DOI

      10.5183

    • NAID

      10030497169

    • ISSN
      0915-2350, 1881-1337
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Consistent estimators of a concordance probability for doubly-censored time-to-event responses2014

    • Author(s)
      林 賢一,清水 泰隆
    • Organizer
      2014年度統計関連学会連合大会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-09-13 – 2014-09-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] On the nonparametric estimation of a concordance probability for doubly-censored time-to-event response2014

    • Author(s)
      Kenichi Hayashi
    • Organizer
      The 26th International Biometric Conference
    • Place of Presentation
      Firenze Fiera, Italy
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Simultaneous analysis of clustering and dimension reduction for binary variables with application to biomedical data2014

    • Author(s)
      Michio Yamamoto, Kenichi Hayashi
    • Organizer
      The 26th International Biometric Conference
    • Place of Presentation
      Firenze Fiera, Italy
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 打ち切りを伴う生存時間データに対するC統計量のバイアスについて2013

    • Author(s)
      林 賢一
    • Organizer
      日本計算機統計学会第27回大会
    • Place of Presentation
      弘前大学
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Evaluating discriminant performance of a semi-supervised linear discriminant analysis against a supervised one for heteroscedastic normal populations2013

    • Author(s)
      Kenichi Hayashi
    • Organizer
      2013 Joint Statistical Meeting
    • Place of Presentation
      Palais des congres de Montreal, Canada
    • Related Report
      2013 Research-status Report
  • [Presentation] Sample size evaluation in group sequential designs for clinical trials with two continuous endpoints as co-primary contrasts2013

    • Author(s)
      Koko Asakura, Kenichi Hayashi, Takashi Sugimoto, Takashi Sozu, Toshimitsu Hamasaki
    • Organizer
      2013 Joint Statistical Meeting
    • Place of Presentation
      Palais des congres de Montreal, Canada
    • Related Report
      2013 Research-status Report
  • [Presentation] Model-based clustering for multivariate binary data with dimension reduction2013

    • Author(s)
      Michio Yamamoto, Kenichi Hayashi
    • Organizer
      2013 Joint Statistical Meeting
    • Place of Presentation
      Palais des congres de Montreal, Canada
    • Related Report
      2013 Research-status Report
  • [Presentation] 多変量二値データに対する次元縮約を伴うクラスター分析法2013

    • Author(s)
      山本 倫生,林 賢一
    • Organizer
      2013年度統計関連学会連合大会
    • Place of Presentation
      大阪大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Clustering of multivariate binary data via penalized latent class analysis with dimension reduction2013

    • Author(s)
      Michio Yamamoto, Kenichi Hayashi
    • Organizer
      The 6th International Conference of the ERCIM WG on Computational and Methodological Statistics
    • Place of Presentation
      University of London, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] 生存時間データにおけるモデル評価の一考察2013

    • Author(s)
      林 賢一
    • Organizer
      研究集会「統計手法における近年の話題とその応用」
    • Place of Presentation
      KKRホテル広島
    • Related Report
      2013 Research-status Report
  • [Presentation] The effects of unlabeled data on a linear discriminant function for heteroscedastic normal populations

    • Author(s)
      林 賢一
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi