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Research for causal analysis between body mass index and death

Research Project

Project/Area Number 24700278
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Statistical science
Research InstitutionYokohama City University

Principal Investigator

TAGURI Masataka  横浜市立大学, 医学部, 助教 (20587589)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords因果推論 / 疫学 / 臨床研究 / 時間依存性交絡
Outline of Final Research Achievements

For the purpose of examining a causal association between body mass index and death appropriately, I developed and examined statistical methodologies when there exists time-dependent confounding. I developed model selection criterion for two kinds of causal models, Marginal Structural Models and Structural Mean Models. I showed by simulation experiments that the proposed criterion can choose the right causal model with the probability that is higher than existing methods. I further developed estimation and sensitivity analysis methods for evaluating the direct and indirect effects of an exposure variable, in the presence of time-dependent confounding. By an analysis of a cohort data, I found that there is not large time-dependent confounding.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] A principal stratification approach for evaluating natural direct and indirect effects in the presence of treatment-induced intermediate confounding2015

    • Author(s)
      Taguri M, Chiba Y
    • Journal Title

      Statistics in Medicine

      Volume: 34 Issue: 1 Pages: 131-144

    • DOI

      10.1002/sim.6329

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comments on ‘A cautionary note concerning the use of stabilized weights in marginal structural models’ by D. Talbot, J. Atherton, A. M. Rossi, S. L. Bacon, and G. Lefebvre2015

    • Author(s)
      Taguri M
    • Journal Title

      Statistics in Medicine

      Volume: 34 Issue: 8 Pages: 1438-1439

    • DOI

      10.1002/sim.6422

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Model selection criterion for causal parameters in structural mean models based on a quasi-likelihood2014

    • Author(s)
      Taguri M, Matsuyama Y, Ohashi Y
    • Journal Title

      Biometrics

      Volume: 印刷中 Issue: 3 Pages: 721-730

    • DOI

      10.1111/biom.12165

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 直接効果・間接効果の推定および未測定の交絡に対する感度解析2014

    • Author(s)
      田栗正隆
    • Journal Title

      統計数理

      Volume: 印刷中

    • NAID

      120006020812

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comments on ‘An information criterion for marginal structural models’ by R. W. Platt, A. M. Brookhart, S. R. Cole, D. Westreich, and E. F. Schisterman2013

    • Author(s)
      Taguri M, Matsuyama Y
    • Journal Title

      Statistics in Medicine

      Volume: 32 Issue: 20 Pages: 3590-3591

    • DOI

      10.1002/sim.5810

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conditional and unconditional infectiousness effects in vaccine trials2013

    • Author(s)
      Yasutaka Chiba
    • Journal Title

      Epidemiology

      Volume: 24 Issue: 2 Pages: 336-337

    • DOI

      10.1097/ede.0b013e31828261f5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alternative monotonicity assumptions for improving bounds on natural direct effects2013

    • Author(s)
      Chiba Y, Taguri M
    • Journal Title

      International Journal of Biostatistics

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Instruments and bounds for causal effects under the monotonic selection assumption2012

    • Author(s)
      Masataka taguri
    • Journal Title

      International Journal of Biostatistics

      Volume: 8(1) Issue: 1 Pages: 24-24

    • DOI

      10.1515/1557-4679.1386

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Doubly robust estimation of the generalized impact fraction2012

    • Author(s)
      Taguri M, Matsuyama Y, Ohashi Y, Harada A, Ueshima H
    • Journal Title

      Biostatistics

      Volume: 13 Issue: 3 Pages: 455-467

    • DOI

      10.1093/biostatistics/kxr038

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 線形構造平均モデルにおける適合性検定についての検討2014

    • Author(s)
      和泉志津恵, 田栗正隆
    • Organizer
      2014年度統計関連学会連合大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-09-13 – 2014-09-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] A goodness-of-fit test for linear structural mean models2014

    • Author(s)
      Taguri M, Izumi S
    • Organizer
      27th International Biometric Conference
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Estimation of semiparametric accelerated failure time models with covariate measurement error2013

    • Author(s)
      Taguri M
    • Organizer
      34th Annual Conference of the International Society for Clinical Biostatistics
    • Place of Presentation
      Munich, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] Conditional and unconditional infectiousness effects in vaccine trials: the relation and estimation2013

    • Author(s)
      Chiba Y, Taguri M
    • Organizer
      46th Annual Meeting of the Society for Epidemiologic Research
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 共変量の測定誤差を考慮したセミパラメトリック加速モデルの推定2013

    • Author(s)
      田栗正隆
    • Organizer
      2013年度日本計量生物学会年会
    • Place of Presentation
      パルセいいざか(福島県福島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] A principal stratification approach for evaluating natural direct and indirect effects in the presence of intermediate confounding2012

    • Author(s)
      Taguri M, Chiba Y
    • Organizer
      26th International Biometric Conference
    • Place of Presentation
      Kobe
    • Related Report
      2012 Research-status Report
  • [Presentation] Extensions to the regression calibration and substitution approach to mitigating the impact of dosimetric uncertainty on risk regression2012

    • Author(s)
      Doi K, Taguri M, Furukawa K, Misumi M, Toshinaga S
    • Organizer
      26th International Biometric Conference
    • Place of Presentation
      Kobe
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 周辺構造モデルを用いた主要層別効果の推定および感度解析2012

    • Author(s)
      上村夕香理, 田栗正隆, 千葉康敬
    • Organizer
      2012年度日本計量生物学会年会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Vaccines: Benefits and Risks2013

    • Author(s)
      Chiba Y, Taguri M
    • Total Pages
      19
    • Publisher
      iConcept Press
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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