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Flexible statistical analysis for huge and multiple data in life science

Research Project

Project/Area Number 24700290
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bioinformatics/Life informatics
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

Kayano Mitsunori  帯広畜産大学, 畜産学部, 講師 (20590095)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsバイオインフォマティクス / オミックス / 獣医学 / 畜産学 / 統計学 / 畜産 / システム生物学 / 応用統計学
Outline of Final Research Achievements

This study proposed flexible and high-performance statistical methods in bioinformatics and showed applications in medical, veterinary science and animal husbandry. Three objectives in this study were: A) constructing flexible statistical methods for multiple big data in life science (particularly, omics data), B) proposal of statistical methods and application to elucidate systems in animals and plants at molecular-, individual-, population-level, and C) constructing fast statistical methods. For A) and C), this study proposed fast hypothesis testing, high-performance statistical methods on each type of omics data. Their applications included finding diseases biomarkers. For B), we showed statistical applications in this field, particularly for dairy cows. Three types of focus in this study were 1) molecular level (milk composition, blood component, and each type of omics data), 2) individual level (medical records in cows, shape of crop), 3) population level (dairy herd etc).

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (32 results)

All 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (15 results) (of which Int'l Joint Research: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] メルボルン大学(オーストラリア)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Gene set differential analysis of time course expression profiles via sparse estimation in functional logistic model with application to time-dependent biomarker detection2016

    • Author(s)
      Kayano M, Matsui H, Yamaguchi R, Imoto S, Miyano S
    • Journal Title

      Biostatistics

      Volume: 17 Issue: 2 Pages: 235-248

    • DOI

      10.1093/biostatistics/kxv037

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for stillbirths and mortality during the first 24 h of life on dairy farms in Hokkaido, Japan 2005-20092016

    • Author(s)
      Kayano M., Kadohira M., Steavenson M.
    • Journal Title

      Preventive Veterinary Medicine

      Volume: 12 Pages: 50-55

    • DOI

      10.1016/j.prevetmed.2016.03.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differences in progesterone concentrations and mRNA expressions of progesterone receptors in bovine endometrial tissue between the uterine horns ipsilateral and contralateral to the corpus luteum2016

    • Author(s)
      Takahashi H, Haneda S, Kayano M, Matsui M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 4 Pages: 613-618

    • DOI

      10.1292/jvms.15-0366

    • NAID

      130007331494

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Experimental assessment of bone mineral density using quantitative computed tomography in holstein dairy cows2016

    • Author(s)
      Maetani A., Itoh M., Nishihara K., Aoki T., Ohtani M., Shibano K., Kayano M., Yamada T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 7 Pages: 1209-1211

    • DOI

      10.1292/jvms.15-0642

    • NAID

      130005253816

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Screening for ketosis using multiple logistic regression based on milk yield and composition2015

    • Author(s)
      Kayano M., Kataoka T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 11 Pages: 1473-1478

    • DOI

      10.1292/jvms.14-0691

    • NAID

      130005112094

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identifying alterations in metabolic profiles of dairy cows over the past two decades in Japan using principal component analysis2015

    • Author(s)
      Kayano M., Kida K.
    • Journal Title

      Journal of Dairy Science

      Volume: 98 Issue: 12 Pages: 8764-8774

    • DOI

      10.3168/jds.2015-9791

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Construction of a virtual Mycobacterium tuberculosis consensus genome and its application to data from a next generation sequencer2015

    • Author(s)
      Okumura K., Kato M., Kirikae T., Kayano M., Miyoshi-Akiyama T.
    • Journal Title

      BMC Genomics

      Volume: 16 Issue: 1 Pages: 218-218

    • DOI

      10.1186/s12864-015-1368-9

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution of follicles in canine ovary -A simple and rapid method for counting follicles-2015

    • Author(s)
      Hayashi M., Hariya M., Kayano M., Suzuki H.
    • Journal Title

      Cryobiology

      Volume: 71 Issue: 3 Pages: 514-517

    • DOI

      10.1016/j.cryobiol.2015.08.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental investigation of bone mineral density in Thoroughbreds using quantitative computed tomography2015

    • Author(s)
      Yamada K., Sato F., Higuchi T., Nishihara K., Kayano M., Sasaki N., Nambo Y.
    • Journal Title

      Journal of Equine Science

      Volume: 26 Issue: 3 Pages: 81-87

    • DOI

      10.1294/jes.26.81

    • NAID

      130005101256

    • ISSN
      1340-3516, 1347-7501
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of the first follicular wave dominant follicle on the ovary ipsilateral to the corpus luteum is associated with decreased conception rate in dairy cattle2015

    • Author(s)
      Miura R., Haneda S., Kayano M. and Matsui M.
    • Journal Title

      Journal of Dairy Science

      Volume: 98 Pages: 318-321

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detecting Differentially Coexpressed Genes from Labeled Expression Data:A Brief Review2014

    • Author(s)
      Kayano, M., Shiga, M. and Mamitsuka, H.
    • Journal Title

      IEEE/ACM Transactions on Computational Biology and Bioinformatics

      Volume: 11 Issue: 1 Pages: 154-167

    • DOI

      10.1109/tcbb.2013.2297921

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] インフォマティクス解析によるバイオマーカーの検出2014

    • Author(s)
      茅野光範・新飯田俊平
    • Journal Title

      アンチ・エイジング医学

      Volume: 10(1) Pages: 51-55

    • Related Report
      2013 Research-status Report
  • [Journal Article] Multi-omics approach for estimating metabolic networks using low-order partial correlations2013

    • Author(s)
      Kayano M, Imoto S, Yamaguchi R, Miyano S
    • Journal Title

      Journal of Computational Biology

      Volume: 20 Issue: 8 Pages: 571-582

    • DOI

      10.1089/cmb.2013.0043

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between the placental retention time and the reproductive performance at the foal heat in thoroughbred and a comparison with heavy draft2013

    • Author(s)
      Ishii M., Aoki T., Yamakawa K., Magata F., Gojo C., Ito K., Kayano M. and Nambo Y.
    • Journal Title

      Journal of Equine Science

      Volume: 24(2) Pages: 25-29

    • NAID

      10031183045

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] セイヨウハコヤナギの枝で低温脱馴化および馴化過程に起こるタンパク質の変動2016

    • Author(s)
      春日純, 茅野光範, 高橋大輔, 河村幸男, 上村松生
    • Organizer
      日本植物生理学会年会
    • Place of Presentation
      岩手大学(岩手県・盛岡市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 経時測定データに対する数理統計的アプローチと医療における遺伝子データ解析2016

    • Author(s)
      松井秀俊, 茅野光範, 山口類, 井元清哉, 宮野悟
    • Organizer
      岡山大学-九州大学IMI-理研CSRS シンポジウム
    • Place of Presentation
      理化学研究所(神奈川県・横浜市)
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Distribution of follicles in canine ovaries2015

    • Author(s)
      Suzuki H., Hayashi M., Hariya M., Kayano, M.
    • Organizer
      Annual Meeting, the Society for the Study of Reproduction
    • Place of Presentation
      Puerto Rico Convention Center(Puerto Rico, USA)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CTによる馬の骨密度測定法の基礎的検討2014

    • Author(s)
      山田一孝
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Does the ipsilateral locations of the first wave dominant follicle and corpus luteum affects conception rate in cattle?2014

    • Author(s)
      Miura R.
    • Organizer
      9th International Ruminant Reproduction Symposium
    • Place of Presentation
      Hotel Nikko Northland Obihiro
    • Year and Date
      2014-08-25 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Blood biomarkers for Alzheimer's disease revealed by capillary electrophoresis/mass spectrometry (CE/MS)-based metabolomics2014

    • Author(s)
      Takikawa, O.
    • Organizer
      Metabolomics 2014
    • Place of Presentation
      Tsuruoka Washington Hotel
    • Year and Date
      2014-06-23 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Construction of a virtual Mycobacterium tuberculosis consensus genome and its application to data from a next generation sequencer2014

    • Author(s)
      Miyoshi-Akiyama T.
    • Organizer
      114th General Meeting, American Society for Microbiology
    • Place of Presentation
      Boston Convention and Exhibition Center
    • Year and Date
      2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Gene set differential analysis of time course expression profiles via sparse estimation in functional logistic model2013

    • Author(s)
      茅野光範
    • Organizer
      2nd Joint Conference on Informatics in Biology, Medicine and Pharmacology,
    • Place of Presentation
      東京(タワーホール船堀)
    • Related Report
      2013 Research-status Report
  • [Presentation] 分娩後早期からの繁殖検診におけるボディーコンディションスコアと繁殖成績との関係2013

    • Author(s)
      石井三都夫
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ナガイモの種イモ同時切断技術の開発2013

    • Author(s)
      千葉大基
    • Organizer
      農業食料工学会第72回年次大会
    • Place of Presentation
      帯広畜産大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 乳牛の分娩後早期からの繁殖検診におけるボディーコンディションスコアと繁殖成績との関係2013

    • Author(s)
      石井三都夫
    • Organizer
      平成25年度獣医学術北海道地区学会・北海道獣医師大会
    • Place of Presentation
      帯広畜産大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Efficiently discriminating typical time series patterns in omics data based on functional t-test2012

    • Author(s)
      茅野光範
    • Organizer
      Joint Conference on Informatics in Biology, Medicine and Pharmacology
    • Place of Presentation
      東京(タワーホール船堀)
    • Related Report
      2012 Research-status Report
  • [Presentation] 時系列オミックスデータのための関数t-検定2012

    • Author(s)
      茅野光範
    • Organizer
      第7回メタボロームシンポジウム
    • Place of Presentation
      慶応大学鶴岡メタボロームキャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] 関数t-検定と関数ロジスティック回帰のL1正則化による遺伝子選択2012

    • Author(s)
      茅野光範
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 種イモ切断自動化の設計を支援する長芋形状推定方法の開発2012

    • Author(s)
      姜興起
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学
    • Related Report
      2012 Research-status Report
  • [Remarks] 帯広畜産大学 茅野研究室 ホームページ

    • URL

      http://www.obihiro.ac.jp/~kayano/

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 軽度認知障害を検査する方法2015

    • Inventor(s)
      新飯田俊平、滝川修、檜垣小百合、松本健治、茅野光範
    • Industrial Property Rights Holder
      新飯田俊平、滝川修、檜垣小百合、松本健治、茅野光範
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-03
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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