| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we developed a fast and accurate prediction model for RNA-RNA interactions using integer programming, which can formulate various combinatorial problems appearing in the actual world. Here we incorporated accessibility, probability of being involved in interaction, into the formulation of the integer programming problem, achieving much better predictive performance compared with existing methods that do not consider accessibility. As our proposed method can predict interaction sites in base pair resolution more accurately than the earlier methods can do, this work is expected to greatly contribute to functional analysis of regulatory RNAs.
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