| Project/Area Number |
24700299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
NAOYUKI Miyashita 独立行政法人理化学研究所, 生命システム研究センター, 研究員 (20452162)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ラフト / アミロイド前駆体タンパク質 / 膜タンパク質 / 粗視化モデル / レプリカ交換分子動力学法 / MDシミュレーション / 脂質分子 / コレステロール / アルツハイマー病 / APP / シミュレーション / 混合膜 / replica-exchange |
|---|
| Research Abstract |
Bio-membrane consists of membrane proteins and a various variety of lipids. Nano-domains that are called "Raft" are created in such heterogeneous system. The raft contains a lot of cholesterols and Sphingo-lipids. The functions of Amyloid Precursor Proteins (APP), are related to the Alzheimer disease, are affected by the raft. We have investigated the interaction between lipid and APP, and the interaction of membrane proteins in the raft. Our results suggested that the cholesterols are collected around the APP, especially Gly-xxx-Gly motif, and the cholesterols assist the association of APP.
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