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Cellular and circuit mechanisms of functional connections between neural populations: possible roles of oscillatory neural activity

Research Project

Project/Area Number 24700312
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neuroscience in general
Research InstitutionThe University of Tokyo

Principal Investigator

Morita Kenji  東京大学, 教育学研究科(研究院), 講師 (60446531)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords大脳皮質 / 振動 / 短期可塑性 / 脊髄 / シナプス / 共振
Outline of Final Research Achievements

Possible effects of oscillatory neural activity on the neural transmission have been examined using mathematical models. Specifically, estimation of parameters of a model of short-term synaptic plasticity has been done for corticospinal synapses based on the data in the literature, and synaptic transmission was examined by using spike timings obtained from simulation results of a model of cortical (visual cortex) cell. It was found that average transmission (post-synaptic potential) per pre-synaptic spike can become small when apical tuft dendrites of pre-synaptic cortical cell receive inhibitory inputs that oscillate as a population at the beta frequency compared with the cases where inhibitory inputs oscillate at different frequencies or do not periodically oscillate.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2016 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Int'l Joint Research] ユーリッヒ総合研究機構(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Control of layer 5 pyramidal cell spiking by oscillatory inhibition in the distal apical dendrites: a computational modelling study2013

    • Author(s)
      Xiumin Li, Kenji Morita, Hugh P. C. Robinson, Michael Small
    • Journal Title

      Journal of Neurophysiology

      Volume: 109 Issue: 11 Pages: 2739-2756

    • DOI

      10.1152/jn.00397.2012

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of dopamine depletion on cognitive functions: predictions from hypothesized neural circuit mechanisms of reinforcement learning2016

    • Author(s)
      森田賢治
    • Organizer
      SICEライフエンジニアリング部門統合情報生物工学研究会「パーキンソン病の理解と治療をめぐる最近の話題」
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2016-03-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Possible Functional Role of Cortical Beta Rhythm: a Modeling Approach(大脳皮質のβ律動の機能的役割:モデリングによるアプローチ)2014

    • Author(s)
      森田賢治
    • Organizer
      神経オシレーションカンファレンス2014
    • Place of Presentation
      岡崎カンファレンスセンター
    • Year and Date
      2014-07-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Background mechanisms for the suppression of beta rhythm during movement: a modeling approach

    • Author(s)
      Kenji Morita, Xiumin Li, Michael Small, Hugh P. C. Robinson
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2013(LE2013)
    • Place of Presentation
      慶應義塾大学 日吉キャンパス
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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