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Mechanism of auditory cortex to store and recall the pattern of sounds analyzed by two photon imaging

Research Project

Project/Area Number 24700320
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neuroscience in general
Research InstitutionNiigata University

Principal Investigator

TSUKANO Hiroaki  新潟大学, 脳研究所, 助教 (90624338)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords大脳聴覚野 / 和音 / マウス / 脳機能イメージング / 記憶 / 連想 / 聴覚野 / フラビン蛋白蛍光イメージング / 二光子イメージング / 内側膝状体 / 大脳皮質 / 可塑性
Research Abstract

Harmony is a kind of sounds whose components' frequencies are in relation of an integer ratio. Animals perceive the fundamental frequency (F0) which is the greatest common factor of harmonic sounds even if it does not exist. We observed mouse primary auditory cortex with two photon imaging and flavoprotein fluorescence imaging to investigate the neural mechanism to generate this phenomenon. As a result, it was revealed that the primary auditory cortex works as an associative memory circuit, and F0 is one of the components recalled by an associative memory circuit.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (49 results)

All 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (37 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] The Extrageniculate Visual Pathway Generates Distinct Response Properties in the Higher Visual Areas of Mice2014

    • Author(s)
      Manavu Tohmi, Reiko Meguro, Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Journal Title

      Current Biology

      Volume: 24(6) Pages: 587-597

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Extrageniculate Visual Pathway Generates Distinct Response Properties in the Higher Visual Areas of Mice.2014

    • Author(s)
      Manavu Tohmi, Reiko Meguro, Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki.
    • Journal Title

      Current Biology

      Volume: 5 Pages: 587-597

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual map shifts based on whisker-guided cues in the young mouse visual cortex2013

    • Author(s)
      Kohei Yoshitake, Hiroaki Tsukano, Manavu Tohmi, Seiji Komagata, Ryuichi Hishida, Takeshi Yagi, Katsuei Shibuki
    • Journal Title

      Cell Reports

      Volume: 5(5) Pages: 1365-1374

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related deterioration of cortical responses to slow FM sounds in the auditory belt region of adult C57BL/6 mice2013

    • Author(s)
      Hiroaki Tsukano, Masao Horie, Yuusuke Honma, Shinpei Ohga, Ryuichi Hishida, Hirohide Takebayashi, Sugata Takahashi, Katsuei Shibuki
    • Journal Title

      Neurosci. Lett

      Volume: 556 Pages: 204-2209

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auditory cortical areas activated by slow frequency-modulated sounds in mice2013

    • Author(s)
      Yuusuke Honma, Hiroaki Tsukano, Masao Horie, Shinsuke Ohshima, Manavu Tohmi, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Sugata Takahashi, Katsuei Shibuki
    • Journal Title

      PLoS ONE

      Volume: 8(7)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual compartments of the ventral division of the medial geniculate body projecting to the core region of the auditory cortex in C57BL/6 mice2013

    • Author(s)
      Horie Masao, Hiroaki Tsukano, Ryuichi Hishida, Hirohide Takebayashi, Katsuei Shibuki
    • Journal Title

      Neurosci Res

      Volume: 76(4) Pages: 207-212

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visual map shifts based on whisker-guided cues in the young mouse visual cortex.2013

    • Author(s)
      Kohei Yoshitake, Hiroaki Tsukano, Manavu Tohmi, Seiji Komagata, Ryuichi Hishida, Takeshi Yagi, Katsuei Shibuki.
    • Journal Title

      Cell Reports

      Volume: 5 Pages: 1365-1374

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related deterioration of cortical responses to slow FM sounds in the auditory belt region of adult C57BL/6 mice.2013

    • Author(s)
      Hiroaki Tsukano, Masao Horie, Yuusuke Honma, Shinpei Ohga, Ryuichi Hishida, Hirohide Takebayashi, Sugata Takahashi, Katsuei Shibuki.
    • Journal Title

      Neuroscience Letters

      Volume: 556 Pages: 204-209

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory cortical areas activated by slow frequency-modulated sounds in mice.2013

    • Author(s)
      Yuusuke Honma, Hiroaki Tsukano, Masao Horie, Shinsuke Ohshima, Manavu Tohmi, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Sugata Takahashi, Katsuei Shibuki.
    • Journal Title

      PLoS ONE

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual compartments of the ventral division of the medial geniculate body projecting to the core region of the auditory cortex in C57BL/6 mice.2013

    • Author(s)
      Horie Masao, Hiroaki Tsukano, Ryuichi Hishida, Hirohide Takebayashi, Katsuei Shibuki.
    • Journal Title

      Neuroscience Research

      Volume: 76 Pages: 207-212

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Whisker-guided visual map shifts and formation of ocular dominance column-like structures in mice2014

    • Author(s)
      Yoshitake Kohei, Tsukano Hiroaki, Tohmi Manavu, Hishida Ryuichi, Yagi Takeshi, Shibuki Katsuei
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Properties as associative memory circuits in the primary auditory cortex of mice2014

    • Author(s)
      Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Spinal cord imaging during post-ischemic numbness in mice2014

    • Author(s)
      Watanabe Tatsunori, Komagata Seiji, Tsukano Hiroaki, Hishida Ryuichi, Kohno Tatsuro, Baba Hiroshi, Shibuki Katsuei
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Somatosensory cortical responses after crossing nerve transfer in mice2014

    • Author(s)
      Maniwa Keiichi, Yamashita Haruyoshi, Tsukano Hiroaki, Hishida Ryuichi, Shibata Minoru, Endo Naoto, Shibuki Katsuei
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Sound-shape association memory tested using a M-maze in mice2014

    • Author(s)
      Yamagishi Tatsuya, Tsukano Hiroaki, Baba Hironori, Honma Yusuke, Ohsima Shinsuke, Kubota Yamato, Takahashi Kuniyuki, Takahashi Sugata, Shibuki Katsuei
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] マウス視覚記憶:所見文字20秒保持2014

    • Author(s)
      鎌谷 大樹、山岸 達也、渡邉 健児、塚野 浩明、八木 健、澁木 克栄
    • Organizer
      Crest領域会議
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大脳聴覚野の機能イメージング2013

    • Author(s)
      塚野浩明
    • Organizer
      第43回新潟大学脳研究所夏期セミナー
    • Place of Presentation
      新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] Optical imaging of deep brain activity in mice2013

    • Author(s)
      Katsuei Shibuki, Hiroaki Tsukano, Seiji Komagata, Ryuichi Hishida
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Harmonic sound processing in mouse primary auditory cortex revealed by in vivo two-photon calcium imaging2013

    • Author(s)
      Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      国立京都会議場、京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Multiplicity of protocadherins required for cross-modal plasticity in the primary visual cortex of mice2013

    • Author(s)
      Kohei Yoshitake, Hiroaki Tsukano, Manavu Tohmi, Ryuichi Hishida, Takeshi Yagi, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Reduced visual acuity after blockade of feedback inhibitory projections from the parietal association area to the primary visual cortex in mice2013

    • Author(s)
      Ryuichi Hishida, Masao Horie, Hiroaki Tsukano, Manavu Tohmi, Hirohide Takebayashi, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Spinal mechanisms underlying post-ischemic numbness2013

    • Author(s)
      Tatsunori Watanabe, Seiji Komagata, Hiroaki Tsukano, Ryuichi Hishida, Tatsuro Kohno, Hiroshi Baba, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] New subarea in the rostrodorsal part of the primary auditory cortex in mice2013

    • Author(s)
      Hiroaki Tsukano, Masao Horie, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] フラビン蛋白蛍光イメージング法を用いた一過性虚血後のしびれの脊髄機構の解析2013

    • Author(s)
      渡部 達範、駒形 成司、塚野 浩明、菱田 竜一、河野 達郎、馬場 洋、澁木 克栄
    • Organizer
      第6回日本運動器疼痛学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大脳聴覚野の機能イメージング2013

    • Author(s)
      塚野 浩明
    • Organizer
      新潟大学脳研究所夏期セミナー
    • Place of Presentation
      新潟
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optical imaging of deep brain activity in mice.2013

    • Author(s)
      Katsuei Shibuki, Hiroaki Tsukano, Seiji Komagata, Ryuichi Hishida
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Harmonic sound processing in mouse primary auditory cortex revealed by in vivo two-photon calcium imaging.2013

    • Author(s)
      Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Multiplicity of protocadherins required for cross-modal plasticity in the primary visual cortex of mice.2013

    • Author(s)
      Kohei Yoshitake, Hiroaki Tsukano, Manavu Tohmi, Ryuichi Hishida, Takeshi Yagi, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Reduced visual acuity after blockade of feedback inhibitory projections from the parietal association area to the primary visual cortex in mice.2013

    • Author(s)
      Ryuichi Hishida, Masao Horie, Hiroaki Tsukano, Manavu Tohmi, Hirohide Takebayashi, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Spinal mechanisms underlying post-ischemic numbness.2013

    • Author(s)
      Tatsunori Watanabe, Seiji Komagata, Hiroaki Tsukano, Ryuichi Hishida, Tatsuro Kohno, Hiroshi Baba, Katsuei Shibuki
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] New subarea in the rostrodorsal part of the primary auditory cortex in mice.2013

    • Author(s)
      Hiroaki Tsukano, Masao Horie, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀 東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Two-photon calcium imaging of harmonic sound responses in mouse primary auditory cortex2012

    • Author(s)
      Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Biphasic ON-OFF responses in the mouse auditory cortex appeared after exposure to sustained tone bursts2012

    • Author(s)
      Hironori Baba, Hiroaki Tsukano, Yusuke Honma, Shinsuke Ohshima, Yamato Kubota, Ryuichi Hishida, Kuniyuki Takahashi, Sugata Takahashi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Anatomical and physiological parcellation of mouse auditory cortex using flavoprotein fluorescence imaging and immunohistochemistry for nonphosphorylated neurofilament protein2012

    • Author(s)
      Masao Horie, Hiroaki Tsukano, Hirohide Takebayashi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Spinal mechanism underlying post-ischemic numbness : potentiation of Somatosensory cortical responses after transient ischemia in mice2012

    • Author(s)
      Tatsunori Watanabe, Seiji Komagata, Hiroaki Tsukano, Ryuichi Hishida, Tatsuro Kohno, Hirhoshi Baba, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Macro-confocal imaging of mouse brain activity2012

    • Author(s)
      Katsuei Shibuki, Hiroaki Tsukano, Seiji Komagata, Kenji Watanabe, Ryuichi Hishida
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Abnormal appearance of retinal terminals in the dorsal lateral geniculate nucleus of the protocadherin a-deficient mice2012

    • Author(s)
      Reiko Meguro, Manavu Tohmi, Hiroaki Tsukano, Takahiro Hirabayashi, Hirohide Takebayashi, Takeshi Yagi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Preferred speeds of higher visual areas determined by extragenuculate visual pathways2012

    • Author(s)
      Manavu Tohmi, Reiko Meguro, Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional analysis of inhibition mediated by feedback projections from higher association areas to the primary visual cortex in mice2012

    • Author(s)
      Ryuichi Hishida, Masao Horie, Hiroaki Tsukano, Manavu Tohmi, Hirohide Takebayashi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      愛知
    • Related Report
      2013 Final Research Report
  • [Presentation] Two-photon calcium imaging of harmonic sound responses in mouse primary auditory cortex.2012

    • Author(s)
      Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Biphasic ON-OFF responses in the mouse auditory cortex appeared after exposure to sustained tone bursts.2012

    • Author(s)
      Hironori Baba, Hiroaki Tsukano, Yusuke Honma, Shinsuke Ohshima, Yamato Kubota, Ryuichi Hishida, Kuniyuki Takahashi, Sugata Takahashi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Anatomical and physiological parcellation of mouse auditory cortex using flavoprotein fluorescence imaging and immunohistochemistry for nonphosphorylated neurofilament protein.2012

    • Author(s)
      Masao Horie, Hiroaki Tsukano, Hirohide Takebayashi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Spinal mechanism underlying post-ischemic numbness: potentiation of Somatosensory cortical responses after transient ischemia in mice.2012

    • Author(s)
      Tatsunori Watanabe, Seiji Komagata, Hiroaki Tsukano, Ryuichi Hishida, Tatsuro Kohno, Hirhoshi Baba, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Macro-confocal imaging of mouse brain activity.2012

    • Author(s)
      Katsuei Shibuki, Hiroaki Tsukano, Seiji Komagata, Kenji Watanabe, Ryuichi Hishida
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Abnormal appearance of retinal terminals in the dorsal lateral geniculate nucleus of the protocadherin a-deficient mice.2012

    • Author(s)
      Reiko Meguro, Manavu Tohmi, Hiroaki Tsukano, Takahiro Hirabayashi, Hirohide Takebayashi, Takeshi Yagi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Preferred speeds of higher visual areas determined by extragenuculate visual pathways.2012

    • Author(s)
      Manavu Tohmi, Reiko Meguro, Hiroaki Tsukano, Ryuichi Hishida, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional analysis of inhibition mediated by feedback projections from higher association areas to the primary visual cortex in mice.2012

    • Author(s)
      Ryuichi Hishida, Masao Horie, Hiroaki Tsukano, Manavu Tohmi, Hirohide Takebayashi, Katsuei Shibuki
    • Organizer
      第35回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 脳活動の光学的画像解析法2013

    • Inventor(s)
      澁木克栄、塚野浩明
    • Industrial Property Rights Holder
      国立大学法人新潟大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-099032
    • Filing Date
      2013-05-09
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 脳活動の光学的画像解析法2013

    • Inventor(s)
      澁木 克栄、塚野 浩明
    • Industrial Property Rights Holder
      澁木 克栄、塚野 浩明
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-099032
    • Filing Date
      2013-05-09
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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