| Project/Area Number |
24700330
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 側方抑制 / バレル皮質 / シナプス可塑性 / 機能代償 / 抑制性伝達 / 体性感覚 |
|---|
| Research Abstract |
Loss of one type of sensory input can cause improved functionality of other sensory systems. This form of plasticity, cross-modal plasticity, is well established . We have previously shown that visual deprivation (VD) induces trafficking of the AMPA-type glutamate receptors into layer 4 to layer 2/3 synapses (Jitsuki et al., 2011). VD leads to sharpening of the functional whisker-barrel map at layer 2/3. However, the mechanism maintaining sharpened functional whisker barrel map is still unclear.In this study, we found that VD increases evoked miniature inhibitory postsynaptic current (evoked mIPSC) and IPSC/excitatory postsynaptic current (EPSC) ratio in the layer 2/3 to 2/3 synapses (lateral pathway), but not in the layer 4 to 2/3 (vertical pathway). Moreover, VD sharpened functional whisker-barrel map in layer 2/3 of the barrel cortex. These results indicate that VD enhances lateral inhibition and that maintains sharpened neural circuits in the barrel cortex.
|
