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The role of lateral inhibition in compensation of sensory function

Research Project

Project/Area Number 24700330
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neuroscience in general
Research InstitutionYokohama City University

Principal Investigator

JITSUKI Susumu  横浜市立大学, 医学部, 助教 (10546675)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords側方抑制 / バレル皮質 / シナプス可塑性 / 機能代償 / 抑制性伝達 / 体性感覚
Research Abstract

Loss of one type of sensory input can cause improved functionality of other sensory systems. This form of plasticity, cross-modal plasticity, is well established . We have previously shown that visual deprivation (VD) induces trafficking of the AMPA-type glutamate receptors into layer 4 to layer 2/3 synapses (Jitsuki et al., 2011). VD leads to sharpening of the functional whisker-barrel map at layer 2/3. However, the mechanism maintaining sharpened functional whisker barrel map is still unclear.In this study, we found that VD increases evoked miniature inhibitory postsynaptic current (evoked mIPSC) and IPSC/excitatory postsynaptic current (EPSC) ratio in the layer 2/3 to 2/3 synapses (lateral pathway), but not in the layer 4 to 2/3 (vertical pathway). Moreover, VD sharpened functional whisker-barrel map in layer 2/3 of the barrel cortex. These results indicate that VD enhances lateral inhibition and that maintains sharpened neural circuits in the barrel cortex.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (12 results) (of which Invited: 3 results)

  • [Journal Article] Social isolation perturbs experience-driven synaptic glutamate receptor subunit 4 delivery in the developing rat barrel cortex2013

    • Author(s)
      Miyazaki, T., Kunii, M., Jitsuki, S., Sano, A., Kuroiwa, Y., Takahashi, T.
    • Journal Title

      Eur J Neurosci

      Volume: 37 Issue: 10 Pages: 1602-1609

    • DOI

      10.1111/ejn.12188

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Nogo receptor signaling restricts experience-driven synaptic AMPA receptor trafficking in adult brain2013

    • Author(s)
      Jitsuki, S., Nakajima, W., Takahashi, T.
    • Organizer
      Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego convention center, CA, USA
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Nogo receptor signaling restricts experience-driven synaptic AMPA receptor trafficking in adult brain2013

    • Author(s)
      Jitsuki, S., Nakajima, W., Takahashi, T.
    • Organizer
      Cold spring harbor meeting - Wiring the brain-
    • Place of Presentation
      Cold spring harbor Laboratory, NY, USA
    • Year and Date
      2013-07-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 視覚剥奪ラットの体性感覚野における側方抑制の強化2013

    • Author(s)
      中島和希,實木亨,高橋琢哉
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Nogo受容体シグナルは成熟脳におけるAMPA受容体シナプス移行を制御する2013

    • Author(s)
      實木亨,中島和希,高橋琢哉
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 視覚剥奪ラットの体性感覚野における側方抑制の強化2013

    • Author(s)
      中島 和希、実木 亨、高橋 琢哉
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nogo受容体シグナルは成熟脳におけるAMPA受容体シナプス移行を制御する2013

    • Author(s)
      実木 亨、中島 和希、高橋 琢哉
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nogo receptor signaling restricts experience-driven synaptic AMPA receptor trafficking in adult brain2013

    • Author(s)
      実木 亨、中島 和希、高橋 琢哉
    • Organizer
      Cold spring harbor meeting - Wiring the brain -
    • Place of Presentation
      Cold spring harbor Laboratory, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nogo receptor signaling restricts experience-driven synaptic AMPA receptor trafficking in adult brain2013

    • Author(s)
      実木 亨、中島 和希、高橋 琢哉
    • Organizer
      Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego convention center, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大脳皮質回路の異種感覚間可塑性2013

    • Author(s)
      實木 亨、高橋琢哉
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Cross-modal plasticityの分子機構2012

    • Author(s)
      實木亨
    • Organizer
      富山大学研究推進事業シンポジウム2012 -神経機能回復の新地平-
    • Place of Presentation
      富山大学(富山県)
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 視覚剥奪ラットの体性感覚野における側方抑制の強化2012

    • Author(s)
      中島和希,實木亨,高橋琢哉
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      名古屋国際会館(愛知県)
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Cross-modal plasticityの分子機構

    • Author(s)
      實木 亨
    • Organizer
      -神経機能回復の新地平-富山大学研究推進事業シンポジウム2012
    • Place of Presentation
      富山大学(富山県)
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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