| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study was undertaken to reveal physiological function of sagittalis nucleus of the hypothalamus (SGN) that was newly-identified. SGN are located in a target of sex steroid action that is important for central regulation of food intake and reproduction. We found that neurons in SGN and its surrounding region express histamine receptor 1 (H1R). H1R is exclusively located in the ventrolateral subregion of the female ventromedial nucleus of the hypothalamus (VMN), coexistent with estrogen receptor alpha . Intriguingly, H1R located in the vlVMN showed sensitivity to estrogen, since H1R mRNA was induced in ovariectomized female rats treated with estrogen benzoate. These brain regions have a well-known role in modulation of estrogen-induced feeding and sexual behavior. These finding that the femal VMN contains high levels of estrogen-regulated H1R in the vl region suggests a causal link between histamine signaling and estrogen-induced behavioral function.
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