Elucidateion of the functions of a newly identified hypothalamic region.

• Project/Area Number: 24700331
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neuroscience in general
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MORI HIROKO 京都府立医科大学, 医学(系)研究科(研究院), 助教 (60616895)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エストロゲン / 摂食 / estrogen / energy metabolism / hypothalamus / energy / metabolism

Outline of Final Research Achievements

This study was undertaken to reveal physiological function of sagittalis nucleus of the hypothalamus (SGN) that was newly-identified. SGN are located in a target of sex steroid action that is important for central regulation of food intake and reproduction. We found that neurons in SGN and its surrounding region express histamine receptor 1 (H1R). H1R is exclusively located in the ventrolateral subregion of the female ventromedial nucleus of the hypothalamus (VMN), coexistent with estrogen receptor alpha . Intriguingly, H1R located in the vlVMN showed sensitivity to estrogen, since H1R mRNA was induced in ovariectomized female rats treated with estrogen benzoate. These brain regions have a well-known role in modulation of estrogen-induced feeding and sexual behavior. These finding that the femal VMN contains high levels of estrogen-regulated H1R in the vl region suggests a causal link between histamine signaling and estrogen-induced behavioral function.

Research Products

• [Journal Article] Estrogenic regulation of histamine receptor subtype H1 expression in ventromedial nucleus of the hypothalamus in female rats. (2014)
  • Author(s): Mori H., Matsuda K. I., Yamawaki M., Kawata M.
  • Journal Title: PLoS One Volume: 印刷中 Issue: 5 Pages: 96232-96232
  • DOI: 10.1371/journal.pone.0096232
  • Peer Reviewed / Open Access
• [Presentation] ラット脳内におけるケトン体利用酵素の分布解析 (2013)
  • Author(s): 森 浩子
  • Organizer: Neuro2013(第36回日本神経科学大会、第56回日本神経化学会大会、
  • Place of Presentation: 国立京都国際会館
• [Presentation] A detailed mapping of the ketone body utilizing enzyme: Succinyl-CoA: 3-Keto acid CoA-Transferase in rat brain. (2013)
  • Author(s): 森 浩子、 松田 賢一、 山脇正永、河田光博
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都国際会議場
• [Presentation] ラット脳内におけるサクシニル-CoA:3-ケト酸CoA転移酵素の詳細な分布について
  • Author(s): 森 浩子、 松田 賢一、 山脇正永、河田光博
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: かがわ国際会議場
• [Presentation] 未定
  • Author(s): 森 浩子
  • Organizer: 脳の世紀講演会
  • Place of Presentation: 京都市立堀川高等学校
  • Invited
• [Book] 組織細胞化学２０１３ (2013)
  • Author(s): 松田賢一，井上敏昭，森 浩子，河田 光博
  • Publisher: 日本組織細胞化学会 学際企画
• [Remarks] PLOS ONEオンライン速報版掲載】エストロゲンが神経ヒスタミン受容体の発現を制御
  • URL: http://www.kpu-m.ac.jp/doc/news/2014/20140512.html
• [Remarks] エストロゲンが神経ヒスタミン受容体の発現を制御
  • URL: http://www.kpu-m.ac.jp/doc/news/2014/files/7551.pdf