| Project/Area Number |
24700338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
TAKADA Mieko 生理学研究所, 大脳皮質機能研究系, 助教 (30435531)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 錐体細胞 / 抑制性細胞 / シナプス結合 |
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| Research Abstract |
Neocortical pyramidal cells send axons to diverse extracortical targets, but also issue the intracortical collaterals innervating other pyramidal cells as well as GABAergic cells. Recently it has been proposed that most of GABAergic interneurons make synapses on nearby pyramidal cells in a non-selective manner. On the other hand, synaptic connections between pyramidal cells are selectively formed according to extracortical projection patterns. Therefore, we analyzed synaptic connections between GABAergic interneurons and pyramidal cells specified projection targets. First, we investigated the connections with FS (fast spiking) cells.The connection probability from pyramidal cells to FS was similar. The short term plasticity of EPSCs was depressive in most connections from CCS to FS cell, but facilitatory in connections from CPn to FS cells. These results suggest that the intracortical inhibitory system is organized according to diverse pyramidal projection subtypes.
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