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Excitatory-Inhibitory reccurent networks in layer5 frontal cortex

Research Project

Project/Area Number 24700338
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neuroscience in general
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

TAKADA Mieko  生理学研究所, 大脳皮質機能研究系, 助教 (30435531)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords錐体細胞 / 抑制性細胞 / シナプス結合
Research Abstract

Neocortical pyramidal cells send axons to diverse extracortical targets, but also issue the intracortical collaterals innervating other pyramidal cells as well as GABAergic cells. Recently it has been proposed that most of GABAergic interneurons make synapses on nearby pyramidal cells in a non-selective manner. On the other hand, synaptic connections between pyramidal cells are selectively formed according to extracortical projection patterns. Therefore, we analyzed synaptic connections between GABAergic interneurons and pyramidal cells specified projection targets. First, we investigated the connections with FS (fast spiking) cells.The connection probability from pyramidal cells to FS was similar. The short term plasticity of EPSCs was depressive in most connections from CCS to FS cell, but facilitatory in connections from CPn to FS cells. These results suggest that the intracortical inhibitory system is organized according to diverse pyramidal projection subtypes.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Dopaminergic control of motivation and reinforcement learning : a closed-circuit account for reward-oriented behavior2013

    • Author(s)
      Morita K, Morishima M, Sakai K, Kawaguchi Y.
    • Journal Title

      J Neurosci

      Pages: 8866-90

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Layer 5 Pyramidal Cell Subtypes Relay Cortical Feedback from Secondary to Primary Motor Areas in Rats2013

    • Author(s)
      Ueta Y, Otsuka T, Morishima M, Ushimaru M, Kawaguchi Y.
    • Journal Title

      Cereb Cortex

      Pages: 1-15

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopaminergic control of motivation and reinforcement learning: a closed-circuit account for reward-oriented behavior2013

    • Author(s)
      Kenji Morita, Mieko Morishima, Katsuyuki Sakai, Yasuo Kawaguchi
    • Journal Title

      The Journal of Neuroscience

      Volume: 33 Issue: 20 Pages: 8866-8890

    • DOI

      10.1523/jneurosci.4614-12.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple layer 5 pyramidal cell subtypes relay cortical feedback from secondary to primary motor areas in rats.2013

    • Author(s)
      植田 禎史
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 9 Pages: 1-15

    • DOI

      10.1093/cercor/bht088

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reinforcement learning : computing the temporal difference of values via distinct corticostriatal pathways2012

    • Author(s)
      Morita K, Morishima M, Sakai K, Kawaguchi Y.
    • Journal Title

      Trends Neurosci

      Pages: 457-67

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reinforcement learning: computing the temporal difference of values via distinct corticostriatal pathways2012

    • Author(s)
      Morita K
    • Journal Title

      Trends Neurosci

      Volume: 35 Issue: 8 Pages: 457-467

    • DOI

      10.1016/j.tins.2012.04.009

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Excitatory / inhibitory recurrent networks dependent on the pyramidal projection types in the frontal cortexm2014

    • Author(s)
      森島美絵子
    • Organizer
      第6回NAGOYAグローバルリトリート
    • Place of Presentation
      あいち健康プラザ(愛知県、大府市)
    • Year and Date
      2014-02-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Excitatory / inhibitory recurrent networks dependent on the pyramidal projection types in the frontal cortex2014

    • Author(s)
      森島 美絵子
    • Organizer
      第6回NAGOYAグローバルリトリート
    • Place of Presentation
      あいち健康プラザ(愛知県、大府市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 前頭皮質第5層における興奮性・抑制性細胞間の結合性2012

    • Author(s)
      森島美絵子、川口泰雄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 前頭皮質第5層における興奮・抑制性細胞間の結合特性

    • Author(s)
      森島 美絵子, 川口泰雄
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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