Role for pyramidal cells and interneurons in prefrontal cortex underlying decision making and output information to subcortical areas
| Project/Area Number |
24700345
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
HANDA Takashi 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (40567335)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経生理 / ニューロン活動 / 前頭前野 / ラット / 大脳皮質 / 線条体 / 行動選択 / 多細胞集団 / 国際情報交換 |
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| Research Abstract |
To investigate roles for pyramidal cells (RS) and interneurons (FS) in prefrontal cortex (PFC) underlying choice behavior, we recorded neural activity during task performance and analyzed how single (multiple) neurons code the upcoming choice.
RS and FS similarly contribute to the choice behavior. When cues were novel for rats, ensemble activity was similar as that when the cue was familiar. It suggests that prior experiences in the PFC bias the ensemble patterns even if sensory cue is novel. It is successful method to combine use of neurotracor to label projection neurons to striatum with juxtacelluar recording/labeling method.
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Report
(3 results)
Research Products
(10 results)
