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Role for pyramidal cells and interneurons in prefrontal cortex underlying decision making and output information to subcortical areas

Research Project

Project/Area Number 24700345
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neuroscience in general
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

HANDA Takashi  独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (40567335)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経生理 / ニューロン活動 / 前頭前野 / ラット / 大脳皮質 / 線条体 / 行動選択 / 多細胞集団 / 国際情報交換
Research Abstract

To investigate roles for pyramidal cells (RS) and interneurons (FS) in prefrontal cortex (PFC) underlying choice behavior, we recorded neural activity during task performance and analyzed how single (multiple) neurons code the upcoming choice.
RS and FS similarly contribute to the choice behavior. When cues were novel for rats, ensemble activity was similar as that when the cue was familiar. It suggests that prior experiences in the PFC bias the ensemble patterns even if sensory cue is novel. It is successful method to combine use of neurotracor to label projection neurons to striatum with juxtacelluar recording/labeling method.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Modulation of neuronal activity with cue-invariant shape discrimination in the primate superior temporal sulcus2014

    • Author(s)
      S. Unno, T. Handa, Y. Nagasaka, M. Inoue, A. Mikami
    • Journal Title

      Neuroscience

      Volume: 268 Pages: 221-235

    • URL

      http://www.sciencedirect.com/science/article/pii/S0306452214002371

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reward-modulated motor information in identified striatum neurons.2013

    • Author(s)
      Yoshikazu Isomura, Takashi Takekawa, Rie Harukuni, Takashi Handa, Hidenori Aizawa, Masahiko Takada, and Tomoki Fukai
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 25 Pages: 10209-10220

    • DOI

      10.1523/jneurosci.0381-13.2013

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Neural ensemble dynamics in rat dorsomedial prefrontal cortex during probabilistic sensory-cued choice2013

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki
    • Organizer
      Bernstein Conference, poster W65, 2013
    • Place of Presentation
      Tuebingen, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Neural ensemble dynamics in rat dorsomedial prefrontal cortex during a sensory-guided choice task2013

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki
    • Organizer
      Neuro2013, P3-2-69, 2013
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Neural ensemble dynamics in rat dorsomedial prefrontal cortex during a sensory-guided choice task2013

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, Fukai Tomoki
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neural ensemble dynamics in rat dorsomedial prefrontal cortex during probabilistic sensory-cued choice2013

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, Fukai Tomoki.
    • Organizer
      Bernstein Conference
    • Place of Presentation
      Tuebingen, Germany
    • Related Report
      2013 Annual Research Report
  • [Presentation] Representation of sensory feature and spatial choice in dorsomedial prefrontal cortex of rat making action decision using sensory information2012

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans, U.S.A.(Abstract, 38:811.06, 2012)
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell type-specific activity in rodent prefrontal cortex for making action decision using novel information2012

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki
    • Organizer
      The 8th Federation of European Neuroscience Society Forum, 22.10, 2012
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell type-specific activity in rodent prefrontal cortex for making action decision using novel information.2012

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki.
    • Organizer
      The 8th Federation of European Neuroscience Society Forum
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] Representation of sensory feature and spatial choice in dorsomedial prefrontal cortex of rat making action decision using sensory information.2012

    • Author(s)
      Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki.
    • Organizer
      Society for Neuroscience (Neuroscience2012)
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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