| Project/Area Number |
24700348
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Kanazawa Medical University (2013)
The Institute of Physical and Chemical Research (2012) |
|---|
Principal Investigator |
UEDA Yoshibumi 金沢医科大学, 医学部, 特定助教 (60391877)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 神経科学 / 脳神経 / 脂質 / FRET / 蛍光寿命 / シナプス可塑性 / ホスファチジルイノシトール3,4,5-三リン酸 / シナプス / PIP2 / シナプス構造可塑性 |
|---|
| Research Abstract |
Synapses change its morphology and size in response to outputs out of a brain, and therefore provide flexibility to neuronal network in brain. Phosphatidylinositol 3,4,5-trisphoshate (PIP3) plays important roles in neuronal functions such as dendritic arborization and synapse plasticity. It has been unknown how PIP3 work for synapses. In the present study, I found that PIP3 regulates spinule formation in a single dendritic spine during long-term potentiation.
|
