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hnRNPA1 as a new neural cell differentiation development regulator -Aim at psychiatric disorder medical treatment-

Research Project

Project/Area Number 24700358
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionFujita Health University

Principal Investigator

MANABE Takayuki  藤田保健衛生大学, 総合医科学研究所, 准教授 (90382283)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords神経発生・分化・異常 / 精神疾患 / hnRNPA1 / オリゴデンドロサイト / 統合失調症 / スプライシング
Research Abstract

Alternative pre-mRNA splicing is a fundamental strategy for eukaryotes to provide a substantial complexity in proteome from the limited genome size. It must be precisely controlled to ensure their proper physiological functions, and thus disorders in this process often end up in serious diseases. There have been accumulating reports of aberrant splicing in the related genes in Schizophrenia (SZ), however, not much study has been carried out with regard to a splicing abnormality implicated in this disease. We have postulated that the aberrant expression of hnRNPA1, as a global splicing silencer, is involved in the pathology of SZ.
Remarkably, we have obtained evidence supporting that the disturbed expression of the hnRNPA1 causes maturation defects of oligodendrocytes through aberrant splicing of SZ-related genes. These results are the first to demonstrate the role of hnRNPA1 in the development of glial cells via control of the related alternative splicing.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 6 results)

  • [Journal Article] Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades2014

    • Author(s)
      Terada K, Izumo N, Suzuki B, Karube Y, Morikawa T, Ishibashi Y, Kameyama T, Chiba K, Sasaki N, Iwata K,
    • Journal Title

      Neurochemistry International

      Volume: 69 Issue: 1 Pages: 9

    • DOI

      10.1016/j.neuint.2014.02.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The human oligodendrocyte proteome.2013

    • Author(s)
      Iwata K, Café-Mendes CC, Schmitt A, Steiner J, Manabe T, Matsuzaki H, Falkai P, Turck CW, Martins-de-
    • Journal Title

      Proteomis

      Volume: 13 Issue: 23-24 Pages: 3548-3663

    • DOI

      10.1002/pmic.201300201

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症における選択的スプライシング調節の破綻2013

    • Author(s)
      眞部孝幸、森川智美
    • Journal Title

      藤田学園医学会誌

      Volume: 37巻 Pages: 15-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] 統合失調症における選択的スプライシング調節の破綻2013

    • Author(s)
      眞部孝幸,森川智美
    • Journal Title

      藤田学園医学会誌

      Volume: 37 Pages: 15-20

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.2012

    • Author(s)
      Nishiyama, C., Uesaka, T., Manabe, T., Yonekura, Y., Nagasawa, T., Newgreen, D.F., Young, H.M., *Enomoto, H.
    • Journal Title

      Nat. Neurosci.

      Volume: 15(9) Issue: 9 Pages: 1211-1218

    • DOI

      10.1038/nn.3184

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vldlr overexpression causes hyperactivity in rats.2012

    • Author(s)
      Iwata K
    • Journal Title

      Mol Autism.

      Volume: 3 Issue: 1 Pages: 11-11

    • DOI

      10.1186/2040-2392-3-11

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Triggers for Autism: genetic and environmental factors2012

    • Author(s)
      Matsuzaki H, Iwata K, Manabe T, Mori N
    • Journal Title

      Journal of Central Nervous System Disease

      Volume: 4 Pages: 1-10

    • DOI

      10.4137/jcnsd.s9058

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased voluntary activity and amygdala levels of serotonin and dopamine in ovariectomized rats2012

    • Author(s)
      Izumo N, Ishibashi Y, Ohba M, Morikawa T and Manabe T.
    • Journal Title

      Behavioural Brain Research

      Volume: 227巻 Issue: 1 Pages: 1-6

    • DOI

      10.1016/j.bbr.2011.10.031

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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