| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
MicroRNA-124a (miR-124a) is one of the most abundant microRNAs in the central nervous system (CNS). In order to clarify roles of miR-124a in the mature CNS, we are generating floxed miR-124a mice. We established the conditional gene deletion method upon Cre-recombinase expression in the retina and the brain using adeno-associated virus (AAV). Moreover, we identified candidate miR-124a target genes in the brain. The results in the current study contributed to progress of understanding on the miR-124a function in the CNS.
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