Mechanism of aggregation-independent neurotoxicity induced by tau

• Project/Area Number: 24700368
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Doshisha University
• Principal Investigator: XIE Ce 同志社大学, 生命医科学部, 特別研究員 (10598981)
• Project Period (FY): 2012 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: タウ / タウオパチー / 認知症 / 線虫 / アクチン

Research Abstract

Microtubule-associated protein tau aggregates and deposits in the degenerated neurons of many dementia developed with aging. These diseases are called tauopathies, which mechanism is still unclear. The proteins that associated with the abnormal tau are considered to be deeply related to the neurotoxic mechanism. In this study, we identified the proteins that may be involved in the toxic mechanism of tau, using a C. elegans model, in which abnormal tau was expressed without aggregation formation.

Research Products

• [Journal Article] The homologous carboxyl-terminal domains of microtubule-associated protein 2 and Tau induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. (2014)
  • Author(s): Xie C, Miyasaka T, Yoshimura S, Hatsuta H, Yoshina S, Kage-Nakadai E, Mitani S, Murayama S, Ihara Y.
  • Journal Title: PLoS One Volume: 10 Pages: 1371-1371
• [Journal Article] The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. (2014)
  • Author(s): Xie, C., T. Miyasaka, S. Yoshimura, H. Hatsuta, S. Yoshina, E. Kage-Nakadai, S. Mitani, Murayama, S., Y. Ihara
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e89796-e89796
  • DOI: 10.1371/journal.pone.0089796
  • Peer Reviewed
• [Presentation] タウオパチー発症機構におけるMAP2の関与 (2012)
  • Author(s): Xie Ce et al.
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: Tsukuba, Japan.
  • Year and Date: 2012-10-26
• [Presentation] Phosphorylated tau and microtubule-associated protein 2 induce neuronal toxicity in C. elegans (2012)
  • Author(s): Xie Ce et al.
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry&The 55th Annual Meeting of the Japanese Society for Neurochemistry.
  • Place of Presentation: Kobe, Japan.
• [Presentation] Potential contribution of microtubule-associated protein 2 to the pathogenesis of Alzheimer's disease (2012)
  • Author(s): Xie Ce et al.
  • Organizer: The 42nd annual meeting of the Society for Neuroscience.
  • Place of Presentation: New Orleans, LA, USA.
• [Presentation] Phosphorylated tau and microtubule-associated protein 2 induce neuronal toxicity in C. elegans (2012)
  • Author(s): Ce Xie et al.
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry&The 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe, Japan.
• [Presentation] Potential contribution of microtubule-associated protein 2 to the pathogenesis of Alzheimer’s disease (2012)
  • Author(s): Ce Xie et al.
  • Organizer: The 42nd annual meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, LA, USA.