| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
11C-Pittsburgh compound B (PiB) uptake in PET images is frequently used to analyze β amyloid (Aβ) deposition in living individuals, but its correlation with histologically determined Aβ has not been examined. Six cases underwent PiB-PET imaging, and their brains were analyzed neuropathologically. PiB uptake (reported as standardized uptake value ratio [SUVR]) was analyzed in 11 cortical and 10 subcortical grey matter areas and compared with the Aβ load seen with immunohistochemistry. SUVR and Aβ deposition were strongly correlated in the cortical regions of two PiB-positive cases (Alzheimer’s disease [AD]). The other PiB-positive case showed focal PiB uptake. In this case and the 3 PiB-negative cases, there was no correlation between regional SUVR and Aβ deposition. PiB uptake was not correlated with Aβ deposition in subcortical regions. Our results suggest that high cortical SUVR is a reliable marker of AD. Subcortical PiB positivity must be interpreted more carefully.
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