Functional analysis of DISC1 using Disc1-knockout mouse
Project/Area Number |
24700377
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Nagoya University |
Principal Investigator |
TSUBOI Daisuke 名古屋大学, 医学(系)研究科(研究院), 特任助教 (80584672)
|
Co-Investigator(Renkei-kenkyūsha) |
KAIBUCHI Kozo 名古屋大学, 大学院医学系研究科, 教授 (00169377)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 統合失調症 / 神経科学 / シナプス可塑性 |
Outline of Final Research Achievements |
Schizophrenia is a devastating psychiatric disorder affecting 1% of the population worldwide. The DISC1 gene locus was originally identified at the breakpoint of a balanced (1;11) (q42;q14) chromosome translocation that co-segregates with schizophrenia, bipolar disorder, and recurrent major depression in a large Scottish family. Therefore, DISC1 gene is a promising susceptibility factor for schizophrenia. In the present study, using a proteomic analysis, I identified RNA-binding proteins including HZF as novel DISC1-interactors. HZF is a component of the RNA granules with inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) mRNA, which acts as a key regulator for synaptic plasticity. DISC1 co-localized with HZF and ITPR1 mRNA in hippocampal dendrites. Furthermore, DISC1 directly associated with several mRNAs including that of ITPR1. The impairment of DISC1 function prohibited the dendritic transport of ITPR1 mRNA and caused altered synaptic plasticity
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.2015
Author(s)
Tsuboi D, Kuroda K, Tanaka M, Namba T, Iizuka Y, Taya S, Shinoda T, Hikita T, Muraoka S, Iizuka M, Nimura A, Mizoguchi A, Shiina N, Sokabe M, Okano H, Mikoshiba K, Kaibuchi K
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Journal Title
Nature Neuroscience
Volume: in press
Issue: 5
Pages: 698-707
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility.2015
Author(s)
Kimura H, Tsuboi D, Wang C, Kushima I, Koide T, Ikeda M, Iwayama Y, Toyota T, Yamamoto N, Kunimoto S, Nakamura Y, Yoshimi A, Banno M, Xing J, Takasaki Y, Yoshida M, Aleksic B, Uno Y, Okada T, Iidaka T, Inada T, Suzuki M, Ujike H, Kunugi H, Kato T, Yoshikawa T, Iwata N, Kaibuchi K
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Journal Title
Schizophrenia Bulltein
Volume: 41
Issue: 3
Pages: 744-753
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Disrupted-In-Schizoprenia-1 regulates transport of neuronal mRNA.2012
Author(s)
Tsuboi, D., Kuroda, K., Iizuka, Y., Okano, H., Mikoshiba, K., and Kaibuchi, K
Organizer
The 42nd Annual Meeting the Society for Neuroscience Society
Place of Presentation
ニューオリンズ、アメリカ
Related Report
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