| Project/Area Number |
24700378
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
TANAKA Motoki 名古屋大学, 医学(系)研究科(研究院), 助教 (90584673)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経ステロイド / 興奮性シナプス伝達 / 海馬歯状回 |
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| Research Abstract |
Neurosteroids are synthesized de novo in the central nervous system independently of the peripheral endocrine glands and believed to promote learning and memory by modulating synaptic function in the hippocampus. However, as most of the reported studies on the neurosteroid effects were performed exclusively with exogenously applied neurosteroids, little is known to what degree endogenously synthesized neurosteroids contribute to the hippocampal synaptic function. Our latest study showed that endogenously synthesized neurosteroids constitutively potentiate excitatory synaptic transmission in the dentate gyrus of juvenile male hippocampal slices. In this study, we revealed the mechanisms underlying the modulatory actions of endogenous neurosteroids. In addition, we found a decrease in the potentiation of excitatory synaptic transmission by endogenous neurosteroids in aged rats.
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