| Project/Area Number |
24700381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
NAKAMINE Sayomi 琉球大学, 医学(系)研究科(研究院), 助教 (20381105)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | GnRH / GT1-7細胞 / ErbB4 / GPCR / PKD / Gタンパク質 / ErbBファミリー / MAPキナーゼ / Fyn / PYK2 / Gタンパク質共役型受容体 / GT1-7 / タンパク質リン酸化 / PKCδ |
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| Research Abstract |
Gonadotropin-releasing hormone (GnRH) is secreted from hypothalamic neurons (GnRH neurons). To investigate function of the GnRH neuron, we examined the molecular mechanisms of GnRH-induced ERK activation and ErbB4 cleavage in GT1-7 cells. We found that Gq/11 proteins, PKC, PKD, PYK2 and Fyn were involved in ERK activation, while PKD, PYK2 and Fyn did not affect ErbB4 cleavage. These results suggest that ERK activation and ErbB4 cleavage are induced by different molecular mechanisms.
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