Analysis for the transgenerational molecular mechanisms of poor maternal behavior
| Project/Area Number |
24700382
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
TADA Hirobumi 横浜市立大学, 医学部, 助教 (20464993)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | AMPA受容体 / アクチン / Cofilin / 内側前頭前野 / 養育環境 / Coffilin |
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| Outline of Final Research Achievements |
Poor maternal behaviors have often been reported to be transmitted across generations. In this program, to investigate the transgenerational molecular mechanisms of poor maternal behavior, we study the effect of early life environment in the neocortex related social behavior. We have found that early life stress disrupts synaptic AMPA receptor delivery through adulthood by changing actin dynamics in the neocortex. Furthermore, to elucidate the transgenerational molecular mechanisms, we have evaluated correlation between early life stresses, poor maternal care and synaptic AMPA receptor delivery in the neocortex.
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Report
(4 results)
Research Products
(20 results)
