Analysis for the transgenerational molecular mechanisms of poor maternal behavior

• Project/Area Number: 24700382
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Yokohama City University
• Principal Investigator: TADA Hirobumi 横浜市立大学, 医学部, 助教 (20464993)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: AMPA受容体 / アクチン / Cofilin / 内側前頭前野 / 養育環境 / Coffilin

Outline of Final Research Achievements

Poor maternal behaviors have often been reported to be transmitted across generations. In this program, to investigate the transgenerational molecular mechanisms of poor maternal behavior, we study the effect of early life environment in the neocortex related social behavior. We have found that early life stress disrupts synaptic AMPA receptor delivery through adulthood by changing actin dynamics in the neocortex. Furthermore, to elucidate the transgenerational molecular mechanisms, we have evaluated correlation between early life stresses, poor maternal care and synaptic AMPA receptor delivery in the neocortex.

Research Products

• [Journal Article] Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats. (2013)
  • Author(s): Tada H, Kuroki Y, Funabashi T, Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi T.
  • Journal Title: Neuroscience Volume: 248 Pages: 664-669
  • Peer Reviewed
• [Journal Article] Mechanisms underlying disruption of cortical function by neonatal isolation in rodents. (2012)
  • Author(s): Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T.
  • Journal Title: J. Clin Invest. Volume: 122 Issue: 7 Pages: 2690-2701
  • DOI: 10.1172/jci63060
  • Peer Reviewed
• [Journal Article] Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex (2011)
  • Author(s): Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T
  • Journal Title: Brain Research Volume: 30-1435 Pages: 1-7
  • DOI: 10.1016/j.brainres.2011.11.033
  • Peer Reviewed
• [Presentation] 若年期優劣関係を決定する分子メカニズムの解明 (2014)
  • Author(s): 多田敬典、須山紅美子、高橋琢哉
  • Organizer: 包括型脳科学研究推進支援ネットワーク 冬のシンポジウム
  • Place of Presentation: ホテル東京ガーデンパレス(東京都文京区)
  • Year and Date: 2014-12-12
• [Presentation] Neonatal chronic stress alters actin dynamics and experience-driven synaptic plasticity via ADF/cofilin inactivation in the rat neocortex (2014)
  • Author(s): Hirobumi Tada, Kumiko Suyama, Takuya Takahashi
  • Organizer: Neuroscience2014
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Sex difference of the effect of neonatal social isolation stress on experience driven synaptic delivery of AMPA receptors in rat neocortex (2014)
  • Author(s): Naoko Yamamoto, Akira Taka, Kumiko Suyama, Hirobumi Tada, Takuya Takahashi
  • Organizer: Neuroscience2014
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats (2014)
  • Author(s): Kuroki Y, Tada H, Funabashi T, Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi T
  • Organizer: Neuroscience2014
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 低養育環境ストレスによる攻撃行動発現制御の脳内ネットワーク分子メカニズムの解明 (2014)
  • Author(s): 多田敬典、須山紅美子、高橋琢哉
  • Organizer: 第21 回日本行動神経内分泌学研究会全国集会
  • Place of Presentation: ホテル美やま(埼玉県秩父市)
  • Year and Date: 2014-09-03 – 2014-09-05
• [Presentation] Neonatal chronic stress alters actin dynamics and experience-driven synaptic plasticity via ADF/cofilin inactivation in the rat neocortex (2014)
  • Author(s): Hirobumi Tada, Kumiko Suyama, Takuya Takahashi
  • Organizer: CSHL meeting
  • Place of Presentation: New York (USA)
  • Year and Date: 2014-05-28 – 2014-06-02
• [Presentation] Neonatal chronic stress alters actin dynamics and experience-driven synaptic plasticity via ADF/cofilin inactivation in the rat barrel cortex. (2013)
  • Author(s): Tada H, Suyama K, Takahashi T
  • Organizer: Neuroscience2013
  • Place of Presentation: San Diego, USA
• [Presentation] Neonatal chronic stress alters actin dynamics and experience-driven synaptic plasticity via ADF/cofilin inactivation in the rat barrel cortex. (2013)
  • Author(s): Tada H, Suyama K, Takahashi T
  • Organizer: CSHL meeting
  • Place of Presentation: New York, USA
• [Presentation] 幼弱期慢性ストレス付加によるバレル皮質シナプス可塑性変化の分子メカニズムの解明 (2013)
  • Author(s): Tada H, Suyama K, Takahashi T
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館(京都府京都市)
• [Presentation] Neonatal chronic stress alters actin dynamics and experience-driven synaptic plasticity via ADF/cofilin inactivation in the rat barrel cortex (2013)
  • Author(s): Tada H., Suyama K., Takahashi T.
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀(東京都)
  • Invited
• [Presentation] Sex difference of the effect of neonatal social isolation on experience driven synaptic delivery of AMPA receptors in rat barrel cortex (2012)
  • Author(s): Tada H., Suyama K., Takahashi T.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Sex difference of the effect of neonatal social isolation on experience driven synaptic delivery of AMPA receptors in rat barrel cortex (2012)
  • Author(s): Tada H., Suyama K., Takahashi T.
  • Organizer: Neuroscience2013
  • Place of Presentation: New Orleans (USA)
• [Remarks] reserchmap多田敬典
  • URL: http://researchmap.jp/k10/
• [Remarks] 横浜市立大学医学部生理学教室ホームページ
  • URL: http://neurosci.med.yokohama-cu.ac.jp/2.html
• [Remarks] reserch map多田敬典
  • URL: http://researchmap.jp/k10/
• [Remarks] 横浜市立大学医学部生理学研究室ホームページ
  • URL: http://neurosci.med.yokohama-cu.ac.jp/2.html
• [Remarks] 横浜市立大学医学部生理学教室
  • URL: http://neurosci.med.yokohama-cu.ac.jp/2.html