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Research of neural network basis for generating spatiotemporal activity patterns of animal locomotion

Research Project

Project/Area Number 24700395
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology and muscle physiology
Research InstitutionThe University of Tokyo

Principal Investigator

KOHSAKA Hiroshi  東京大学, 新領域創成科学研究科, 助教 (20431900)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsニューロン / シナプス / 神経回路 / 遺伝学 / 運動制御 / ショウジョウバエ / 生理学 / 介在神経細胞 / オプトジェネティクス / 光遺伝学 / 運動回路
Research Abstract

Each animal moves in a certain speed. Though this observation seems obvious, it is still almost unclear how neural circuits generate speed of animal locomotion. In this study, using a motor circuit of Drosophila larvae as a model system, which is amenable to detailed analyses of neuronal networks, we examined the mechanisms of speed control of the larval locomotion. We found that a subset of interneurons, we named per-IN, regulate speed of locomotion by shortening the duration of motor neuronal activities.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (32 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (23 results) (of which Invited: 8 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Serotonin and downstream leucokinin neurons modulate larval turning behavior in Drosophila.2014

    • Author(s)
      Okusawa S, Kohsaka H, Nose A.
    • Journal Title

      The Journal of Neuroscience

      Volume: 34 Issue: 7 Pages: 2544-2558

    • DOI

      10.1523/jneurosci.3500-13.2014

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetic Perturbation of Neural Activity with Laser Illumination in Semi-intact Drosophila Larvae in Motion.2013

    • Author(s)
      Matsunaga T, Fushiki A, Nose A, Kohsaka H.
    • Journal Title

      Journal of Visualized Experiments

      Volume: 77 Issue: 77

    • DOI

      10.3791/50513

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of sensory experience in functional development of Drosophila motor circuits.2013

    • Author(s)
      Fushiki A, Kohsaka H, Nose A.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: 1-10

    • DOI

      10.1371/journal.pone.0062199

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of larval motor circuits inDrosophila2012

    • Author(s)
      Kohsaka, H., Okusawa, S., Itakura, Y., Fushiki, A. and Nose, A.
    • Journal Title

      Development, Growth andDifferentiation

      Volume: 54 Issue: 3 Pages: 408-419

    • DOI

      10.1111/j.1440-169x.2012.01347.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Normal locomotion speed requires pre-motor inhibitory interneurons in Drosophila larva2014

    • Author(s)
      Kohsaka,H., Takasu,E. and Nose,A.
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Mapping neural connections with PMSIs a group of premotor inhibitory interneurons2014

    • Author(s)
      Kohsaka,H., Takasu,E. and Nose,A.
    • Organizer
      Behavioral neurogenetics of larval Drosophila
    • Place of Presentation
      KKR Atami
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Normal locomotion speed requires pre-motor inhibitory interneurons in Drosophila larva2014

    • Author(s)
      Hiroshi Kohsaka, Etsuko Takasu, Akinao Nose
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島大学 郡元キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 可視光線と遺伝学で神経回路のはたらきを調べる2013

    • Author(s)
      Kohsaka,H and Nose,A.
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ショウジョウバエ幼虫の運動制御2013

    • Author(s)
      高坂洋史
    • Organizer
      第7回Motor Control研究会
    • Place of Presentation
      東京大学農学部・弥生講堂
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Segmental control of motor output by pre-motor inhibitory interneurons for generating innate speed of larval locomotion in Drosophila2013

    • Author(s)
      Kohsaka,H. and Nose,A.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Innate speed of larval locomotion is generated by segmental pre-motor inhibitory interneurons2013

    • Author(s)
      Kohsaka,H. and Nose,A.
    • Organizer
      2^<nd> Asi-Pasific Drosophila research conference (APDRC)
    • Place of Presentation
      Seoul National University Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Innate speed of larval locomotion is generated by segmental pre-motor inhibitory interneurons2013

    • Author(s)
      Hiroshi Kohsaka, Akinao Nose
    • Organizer
      2nd Asia-Pasific Drosophila research conference (APDRC)
    • Place of Presentation
      Seoul National University Seoul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] ショウジョウバエ幼虫の運動制御2013

    • Author(s)
      高坂 洋史
    • Organizer
      第7回 Motor Control 研究会
    • Place of Presentation
      東京大学農学部・弥生講堂
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 可視光線と遺伝学で神経回路のはたらきを調べる2013

    • Author(s)
      Hiroshi Kohsaka, Akinao Nose
    • Organizer
      日本遺伝学会 第85回大会
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 時空間パターンを生み出すメゾ回路の作動原理の解明.2012

    • Author(s)
      高坂洋史、能瀬聡直
    • Organizer
      新学術領域研究「メゾスコピック神経回路から探る脳の情報処理基盤」領域会議
    • Place of Presentation
      KKRホテル熱海
    • Related Report
      2013 Final Research Report
  • [Presentation] RNAi-based screening for transcription factors in interneurons for speed control of larval locomotion2012

    • Author(s)
      Teranishi,K., Kohsaka,H. and Nose,A.
    • Organizer
      Japanese Drosophila Research Conference 2012
    • Place of Presentation
      東京慈恵会医科大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetic search for interneurons that interact with PMSIs, a group of larval premotor inhibitory interneurons2012

    • Author(s)
      Kohsaka,H. Takasu,E. and Nose,A.
    • Organizer
      Janelia Farm Conference : Behavioral Neurogenetics of Drosophila larva
    • Place of Presentation
      HHMI/Janelia Farm Research Campus, Ashburn, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Speed control of larval peristalsis by segmentally-arrayed local inhibitory interneurons2012

    • Author(s)
      Kohsaka,H., Takagi,S. and Nose,A.
    • Organizer
      NEUROFLY 2012 14^<th> European Drosophila neurobiology conference
    • Place of Presentation
      パドゥア、イタリア
    • Related Report
      2013 Final Research Report
  • [Presentation] Speed control of larval locomotion by segmentally-arrayed local inhibitory interneurons2012

    • Author(s)
      Kohsaka,H., Takagi,S. and Nose,A.
    • Organizer
      包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Final Research Report
  • [Presentation] 無脊椎動物のCPG2012

    • Author(s)
      高坂洋史
    • Organizer
      生理学研究所研究会:第6回Motor Control研究会
    • Place of Presentation
      自然科学研究機構岡崎コンファレンスセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] Speed control of larval peristalsis by segmentally-arrayed local inhibitory interneurons2012

    • Author(s)
      Hiroshi Kohsaka, Shunsuke Takagi and Akinao Nose
    • Organizer
      NEUROFLY 2012 14th European Drosophila Neurobiology Conference
    • Place of Presentation
      パドゥア、イタリア
    • Related Report
      2012 Research-status Report
  • [Presentation] Genetic search for interneurons that interact with PMSIs, a group of larval premotor inhibitory interneurons2012

    • Author(s)
      Hiroshi Kohsaka, Etsuko Takasu and Akinao Nose
    • Organizer
      Janelia Farm Conference: Behavioral Neurogenetics of Drosophila Larva
    • Place of Presentation
      Howard Hughes Medical Institute/Janelia Farm Research Campus, Ashburn, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Speed control of larval locomotion by segmentally-arrayed local inhibitory interneurons2012

    • Author(s)
      Hiroshi Kohsaka, Shunsuke Takagi and Akinao Nose
    • Organizer
      包括脳ネットワーク 夏のワークショップ
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2012 Research-status Report
  • [Presentation] RNAi-based screening for transcription factors in interneurons for speed control of larval locomotion2012

    • Author(s)
      Koichi Teranishi, Hiroshi Kohsaka and Akinao Nose
    • Organizer
      Japanese Drosophila Research Conference 2012
    • Place of Presentation
      東京慈恵会医科大学(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] 時空間パターンを生み出すメゾ回路の作動原理の解明2012

    • Author(s)
      高坂洋史、能瀬聡直
    • Organizer
      新学術領域研究「メゾスコピック神経回路から探る脳の情報処理基盤」領域会議
    • Place of Presentation
      KKRホテル熱海(熱海)
    • Related Report
      2012 Research-status Report
  • [Presentation] Optogenetic dissection of motor circuits in Drosophila larvae2012

    • Author(s)
      能瀬聡直、高坂洋史、高木俊輔
    • Organizer
      「第35回日本神経科学大会」シンポジウム
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 無脊椎動物のCPG2012

    • Author(s)
      高坂洋史
    • Organizer
      生理学研究所研究会:第6回Motor Control 研究会
    • Place of Presentation
      自然科学研究機構 岡崎コンファレンスセンター(岡崎)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 「オプトジェネティクス」ショウジョウバエを用いたオプトジェネティクス研究2013

    • Author(s)
      高坂洋史、能瀬聡直
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2013 Final Research Report
  • [Book] 「オプトジェネティクス 」 ショウジョウバエを用いたオプトジェネティクス研究2013

    • Author(s)
      高坂洋史、能瀬聡直
    • Total Pages
      288
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://bio.phys.s.u-tokyo.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京大学大学院新領域創成科学研究科 能瀬研究室 ホームページ

    • URL

      http://bio.phys.s.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 能瀬研究室ホームページ

    • URL

      http://bio.phys.s.u-tokyo.ac.jp/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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