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Cooperative multineuronal spike activities related to externally- and internally-initiated movements.

Research Project

Project/Area Number 24700399
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology and muscle physiology
Research InstitutionTamagawa University

Principal Investigator

KIMURA Rie  玉川大学, 脳科学研究所, 嘱託研究員 (60513455)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords神経生理学 / 大脳皮質 / 運動野 / 神経回路 / ラット
Research Abstract

We examined neuronal activities and their spike synchrony from deep layer in primary (M1) and secondary motor cortex (M2) of rats performing an operant behavioral task under a head-fixed condition. The operant behavioral task required the rats to pull a lever using their forelimb in response to a cue tone (external trials) or pull it spontaneously without the cue (internal trials) after waiting for at least one second. We found that synchronous activities are stable and little dependent on motor functions, and that different types of motor initiation are represented not as synchronous activities but as difference of firing rate, especially in M2. The changeability in synchronous activities was almost stochastic in population, suggesting the stability may enable a reliable motor execution.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (20 results) (of which Invited: 1 results)

  • [Journal Article] Reinforcing operandum: rapid andreliable learning of skilled forelimbmovements by head-fixed rodents2012

    • Author(s)
      Kimura R, et al. Sakai Y
    • Journal Title

      Journal of Neurophysiology

      Volume: vol.108 Issue: 6 Pages: 1781-1792

    • DOI

      10.1152/jn.00356.2012

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] マルチニューロン記録実験の実用プロトコール2012

    • Author(s)
      礒村宜和,木村梨絵,高橋宗良
    • Journal Title

      玉川大学脳科学研究所紀要

      Volume: 5 Pages: 35-42

    • NAID

      10028190885

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 解説 : 傍細胞(ジャクスタセルラー)記録法2012

    • Author(s)
      礒村宜和,木村梨絵,齊木愛希子,塚元葉子
    • Journal Title

      玉川大学脳科学研究所紀要

      Volume: 5 Pages: 27-30

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 解説:傍細胞(ジャクスタセルラー)記録法2012

    • Author(s)
      礒村宜和, 木村梨絵, 齊木愛希子, 塚元葉子
    • Journal Title

      玉川大学脳科学研究所紀要

      Volume: 5 Pages: 27-30

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 運動発現中のラットにおける運動野細胞の同期的活動の集団特性2014

    • Author(s)
      木村梨絵
    • Organizer
      生理学研究所所長招聘セミナー
    • Place of Presentation
      生理学研究所(愛知県)
    • Year and Date
      2014-02-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas2013

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y.
    • Organizer
      第43回北米神経科学会年会
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Year and Date
      2013-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Cooperative multineuronal spike activities related to externally- and intern ally-initiated movements in rat primary and secondary motor cortices2013

    • Author(s)
      Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y.
    • Organizer
      第36回日本神経科学大会第56回日本神経化学会大会第23回日本神経回路学会大会合同大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas2013

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y.
    • Organizer
      第36回日本神経科学大会第56回日本神経化学会大会第23回日本神経回路学会大会合同大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭部固定ラットの前肢運動課題遂行に伴う運動野の神経同期活動2013

    • Author(s)
      木村梨絵,齊木愛希子,塚元葉子,酒井裕,礒村宜和
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Diversity and synchrony of multineuronal spike activities in rat primary and secondary motor cortices during externally- and internally-initiated movements2012

    • Author(s)
      Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y.
    • Organizer
      第42回北米神経科学会年会
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans, USA
    • Year and Date
      2012-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Ensemble spiking activity in rat primary and secondary motor cortices during execution/nonexecution of voluntary movement2012

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Spout-lever manipulation : efficient learning of forelimb movements by head-fixed rats2012

    • Author(s)
      Fujiwara-Tsukamoto Y, Kimura R, Saiki A, Sakai Y, Isomura Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Coordinated multineuronal spiking activities related to externally- and internally-initiated movements in rat primary and secondary motor cortices2012

    • Author(s)
      Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 外発性・内発性運動に伴うラット一次・二次運動野の協調的神経活動

    • Author(s)
      木村梨絵、齊木愛希子、塚元葉子、酒井裕、礒村宜和
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館 (京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラットの吻側・尾側前肢運動野における運動発現と出力制御に関連したマルチニューロン活動

    • Author(s)
      齊木愛希子、木村梨絵、塚元葉子、酒井裕、礒村宜和
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館 (京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas.

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Organizer
      The 43rd Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 運動発現中のラットにおける運動野細胞の同期的活動の集団特性

    • Author(s)
      木村梨絵
    • Organizer
      生理学研究所 所長招聘セミナー
    • Place of Presentation
      生理学研究所 (愛知県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cooperative multineuronal spike activities related to externally- and intern ally-initiated movements in rat primary and secondary motor cortices.

    • Author(s)
      Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経回路学会大会 合同大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Neuronal ensemble activity for motor control with different forces in rat caudal and rostral forelimb areas.

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経回路学会大会 合同大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] 頭部固定ラットの前肢運動課題遂行に伴う運動野の神経同期活動

    • Author(s)
      木村梨絵, 齊木愛希子, 塚元葉子, 酒井裕, 礒村宜和
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Diversity and synchrony of multineuronal spike activities in rat primary and secondary motor cortices during externally- and internally-initiated movements.

    • Author(s)
      Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Organizer
      第42回北米神経科学会年会
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Ensemble spiking activity in rat primary and secondary motor cortices during execution/non-execution of voluntary movement.

    • Author(s)
      Saiki A, Kimura R, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Spout-lever manipulation: efficient learning of forelimb movements by head-fixed rats.

    • Author(s)
      Fujiwara-Tsukamoto Y, Kimura R, Saiki A, Sakai Y, Isomura Y
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Coordinated multineuronal spiking activities related to externally- and internally-initiated movements in rat primary and secondary motor cortices.

    • Author(s)
      Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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