Functional brain optical analysis by implantable neural interface device for artificial vision.

• Project/Area Number: 24700411
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Fusional basic brain science
• Research Institution: Kinki University
• Principal Investigator: KOBAYASHI Takuma 近畿大学, 東洋医学研究所, 助教 (80582288)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: CMOSイメージセンサ / 蛍光イメージング / 電位感受性色素 / Ca2+イメージング / 人工視覚 / 電気生理 / optogenetics / 脳機能解析 / 脳内埋植型デバイス / 視覚野 / マウス / 行動試験

Research Abstract

A novel methodology for optical communication with neural cells in the brain by using the implantable neural interface device which based on CMOS technology was newly estimated. Such technology is expected to play an important role towards the resolution of issues that a conventional artificial vision device of the brain stimulation type has.

Research Products

• [Journal Article] Functional brain fluorescence plurimetry in rat by implantable concatenated CMOS imaging system (2014)
  • Author(s): Takuma Kobayashi, Hiroyuki Masuda, Chikara Kitsumoto, Makito Haruta, Mayumi Motoyama, Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Sadao Shiosaka, Jun Ohta
  • Journal Title: Biosensors and Bioelectronics Volume: 53 Pages: 31-36
  • DOI: 10.1016/j.bios.2013.09.033
  • Peer Reviewed
• [Journal Article] Novel implantable imaging system for enabling simultaneous multiplanar and multipoint analysis for fluorescence potentiometry in the visual cortex. (2012)
  • Author(s): Kobayashi T, (他11名)
  • Journal Title: Biosens Bioelectron Volume: 38 Issue: 1 Pages: 21-30
  • DOI: 10.1016/j.bios.2012.06.035
  • Peer Reviewed
• [Journal Article] Biomedical Devices based on Semiconductor Microelectronics Technologies (2011)
  • Author(s): 太田淳, 小林琢磨, 野田俊彦, 笹川清隆, 徳田崇
  • Journal Title: IEEJ Transactions on Sensors and Micromachines Volume: 131 Issue: 12 Pages: 404-408
  • DOI: 10.1541/ieejsmas.131.404
  • NAID: 10030533195
  • ISSN: 1341-8939, 1347-5525
  • Peer Reviewed
• [Presentation] A Micro Imaging Device for Measuring Neural Activities in the Mouse Deep Brain with Minimal Invasiveness (2012)
  • Author(s): Jun Ohta, Chikara Kitsumoto, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Mayumi Motoyama, Yasumi Ohta, Takuma Kobayashi, Yasuaki Ishikawa, Sadao Shiosaka
  • Organizer: Biomedical Circuits and Systems Conference
  • Place of Presentation: Sheraton Hsinchu Hotel, TAIWAN
  • Year and Date: 2012-11-29
• [Presentation] An implantable CMOS-based device with hexagonal shape for wide-area brain functional imaging (2012)
  • Author(s): Makito Haruta, Takuma Kobayashi, Chikara Kitsumoto, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: NEUROSCIENCE 2012
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-14
• [Presentation] CMOS-based on-chip bio-image sensor with integrated micro LED array for optogenetics (2012)
  • Author(s): Takashi Tokuda, Tomoaki Miyatani, Yasuyo Maezawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: NEUROSCIENCE 2012
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-14
• [Presentation] A CMOS on-chip Image Sensor with Integrated LED Array for Optogenetics (2012)
  • Author(s): Takashi Tokuda, Tomoaki Miyatani, Yosmongkol Sawadsaringkarn, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: 2012 International Conference on Solid State Devices and Materials(SSDM2012)
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2012-09-26
• [Presentation] A CMOS-based implantable imaging device for wide-area brain functional imaging (2012)
  • Author(s): Makito Haruta, Takuma Kobayashi, Chikara Kitsumoto, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: 2012 International Conference on Solid State Devices and Materials(SSDM2012)
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 2012-09-25
• [Presentation] in vitroおよびin vivoオプトジェネティクス向け光刺激・イメージングデバイス (2012)
  • Author(s): 徳田崇,宮谷友彰, Yosmongkol Sawadsaringkarn,前澤安代,小林琢磨,野田俊彦,笹川清隆,太田淳
  • Organizer: 日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-21
• [Presentation] 脳内埋植型センサによる、げっ歯類の視覚野、体性感覚野の広範囲脳機能蛍光イメージング (2012)
  • Author(s): Takuma Kobayashi, Makito Haruta, Chikara Kitsumoto, Mayumi Motoyama, Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuyuki Ishikawa, Sadao Shiosaka, Jun Ohta
  • Organizer: 日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-21
• [Presentation] オプトジェネティクス応用に向けたマイクロLEDアレイ搭載CMOS神経インターフェースデバイス (2012)
  • Author(s): 宮谷友彰, Yosmongkol Sawadsaringkarn,小林琢磨,野田俊彦,笹川清隆,徳田崇,太田淳
  • Organizer: 応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
  • Year and Date: 2012-09-12
• [Presentation] 生体内脳機能イメージング用CMOS広域計測デバイス (2012)
  • Author(s): 春田牧人,小林琢磨,橘本力,野田俊彦,笹川清隆,徳田崇,太田淳
  • Organizer: 応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
  • Year and Date: 2012-09-12
• [Presentation] CMOS集積回路技術による生体埋め込みデバイス (2012)
  • Author(s): 徳田崇,小林琢磨,野田俊彦,笹川清隆,太田淳
  • Organizer: 応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
  • Year and Date: 2012-09-11
• [Presentation] A CMOS-Based On-Chip Neural Interface Device Equipped with Integrated LED Array for Optogenetics (2012)
  • Author(s): Takashi Tokuda, Tomoaki Miyatani, Yasuyo Maezawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: Annual International IEEE EMBS Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-08-31
• [Presentation] Baseband Signal Transmission Experiment for Intra-Brain Communication with Implantable Image Sensor (2012)
  • Author(s): Kiyotaka Sasagawa, Shogo Yokota, Takashi Matsuda, Peter Davis, Bing Zhang, Keren Li, Takuma Kobayashi, Toshihiko Noda, Takashi Tokuda, Jun Ohta
  • Organizer: Annual International IEEE EMBS Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-08-31
• [Presentation] 刺入型in vivo脳神経活動計測用CMOSイメージングデバイスの開発 (2012)
  • Author(s): 橘本力,小林琢磨,野田俊彦,笹川清隆,徳田崇,元山真由美,太田安美,石川保幸,塩坂貞夫,太田淳
  • Organizer: 映像情報メディア学会年次大会
  • Place of Presentation: 広島市立大学
  • Year and Date: 2012-08-30
• [Presentation] 脳内無線送信を目指したイメージセンサ信号のベースバンド伝送 (2012)
  • Author(s): 笹川清隆,横田昇吾,松田隆志,デイビスピーター,張兵,李可人,小林琢磨,野田俊彦,徳田崇,太田淳
  • Organizer: 電子情報通信学会技術研究報告(IEICE Technical Report)
  • Place of Presentation: 山形大学米沢キャンパス
  • Year and Date: 2012-07-27
• [Presentation] 脳内無線送信を目指したイメージセンサ信号のベースバンド伝送 (2012)
  • Author(s): 笹川清隆,横田昇吾,松田隆志,デイビスピーター,張兵,李可人,小林琢磨,野田俊彦,徳田崇,太田淳
  • Organizer: 情報センシング研究会・集積回路研究会
  • Place of Presentation: 山形大学米沢キャンパス
  • Year and Date: 2012-07-27
• [Presentation] Fluorescence potentiometry using an implantable multiple imaging system to visualize the neural activities in both visual hemispheres of freely-moving mouse (2012)
  • Author(s): Takuma Kobayashi, Mayumi Motoyama, Hiroyuki Masuda, Yasumi Ohta, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Hideki Tamura, Yasuyuki Ishikawa, Sadao Shiosaka, Jun Ohta
  • Organizer: FENS(Federation of European Neuroscience Societies) Forum 2012
  • Place of Presentation: Centre Convencions Internacional Barcelona (CCIB) Barcelona, SPAIN
  • Year and Date: 2012-07-16
• [Presentation] An Implantable CMOS Sensor Device for Multi-Area Fluorescence Imaging of A Rat Brain (2012)
  • Author(s): Kiyotaka Sasagawa, Makito Haruta, Chikara Kitsumoto, Takuma Kobayashi, Toshihiko Noda, Takashi Tokuda, Jun Ohta
  • Organizer: Neural Interface Conference
  • Place of Presentation: Salt Palace Convention Center, Salt Lake City, USA
  • Year and Date: 2012-06-18
• [Presentation] CMOS-based Optoelectronic Neural Interface Device for Optogenetics (2012)
  • Author(s): Takashi Tokuda, Tomoaki Miyatani, Yasuyo Maezawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: Neural Interface Conference
  • Place of Presentation: Salt Palace Convention Center, Salt Lake City, USA
  • Year and Date: 2012-06-18
• [Presentation] ラット脳内複数領域計測用CMOSイメージングデバイス (2012)
  • Author(s): 橘本力,増田博之,小林琢磨,野田俊彦,笹川清隆,徳田崇,太田淳
  • Organizer: 情報センシング研究会
  • Place of Presentation: 埼玉大学東京ステーションカレッジ
  • Year and Date: 2012-05-28
• [Presentation] Development of a CMOS-based implantable device for wide-area brain functional imaging (2012)
  • Author(s): Makito Haruta, Takuma Kobayashi, Chikara Kitsumoto, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: International Meeting for Future of Electron Devices, Kansai(IMFEDK 2012)
  • Place of Presentation: Kansai University, JAPAN
  • Year and Date: 2012-05-10
• [Presentation] On-chip metal wire grid polarizer for CMOS image sensor based on 65-nm technology (2012)
  • Author(s): Kiyotaka Sasagawa, Keisuke Ando, Hitoshi Matsuoka, Takuma Kobayashi, Toshihiko Noda, Takashi Tokuda, Ohta Jun
  • Organizer: Conference on Lasers and Electro-Optics (CLEO 2012)
  • Place of Presentation: San Jose Convention Center, USA
  • Year and Date: 2012-05-07
• [Presentation] Development of a CMOS-based implantable device for wide-area brain functional imaging
  • Author(s): Makito Haruta, Takuma Kobayashi, Chikara Kitsumoto, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: International Meeting for Future of Electron Devices, Kansai （IMFEDK 2012)
  • Place of Presentation: Kansai University, JAPAN
• [Presentation] ラット脳内複数領域計測用CMOSイメージングデバイス
  • Author(s): 橘本 力, 増田 博之, 小林 琢磨, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: 情報センシング研究会
  • Place of Presentation: 埼玉大学東京ステーションカレッジ
• [Presentation] FLUORESCENCE POTENTIOMETRY USING AN IMPLANTABLE MULTIPLE IMAGING SYSTEM TO VISUALIZE THE NEURAL ACTIVITIES IN BOTH VISUAL HEMISPHERES OF FREELY-MOVING MOUSE
  • Author(s): Takuma Kobayashi, Mayumi Motoyama, Hiroyuki Masuda, Yasumi Ohta, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Hideki Tamura, Yasuyuki Ishikawa, Sadao Shiosaka, Jun Ohta
  • Organizer: FENS(Federation of European Neuroscience Societies) Forum 2012
  • Place of Presentation: Centre Convencions Internacional Barcelona (CCIB), Barcelona, SPAIN
• [Presentation] 脳内無線送信を目指したイメージセンサ信号のベースバンド伝送
  • Author(s): 笹川 清隆, 横田 昇吾, 松田 隆志, デイビス ピーター, 張 兵, 李 可人, 小林 琢磨, 野田 俊彦, 徳田 崇, 太田 淳
  • Organizer: 情報センシング研究会・集積回路研究会
  • Place of Presentation: 山形大学 米沢キャンパス
• [Presentation] 脳内無線送信を目指したイメージセンサ信号のベースバンド伝送
  • Author(s): 笹川 清隆, 横田 昇吾, 松田 隆志, デイビス ピーター, 張 兵, 李 可人, 小林 琢磨, 野田 俊彦, 徳田 崇, 太田 淳
  • Organizer: 電子情報通信学会技術研究報告 （IEICE Technical Report)
  • Place of Presentation: 山形大学 米沢キャンパス
• [Presentation] 刺入型in vivo 脳神経活動計測用CMOS イメージングデバイスの開発
  • Author(s): 橘本 力, 小林 琢磨, 野田 俊彦, 笹川清隆, 徳田 崇, 元山 真由美, 太田 安美, 石川 保幸, 塩坂 貞夫, 太田 淳
  • Organizer: 映像情報メディア学会年次大会
  • Place of Presentation: 広島市立大学
• [Presentation] CMOS集積回路技術による生体埋め込みデバイス
  • Author(s): 徳田 崇, 小林 琢磨, 野田 俊彦, 笹川 清隆, 太田 淳
  • Organizer: 応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
• [Presentation] 生体内脳機能イメージング用CMOS広域計測デバイス
  • Author(s): 春田 牧人, 小林 琢磨, 橘本 力, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: 応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
• [Presentation] オプトジェネティクス応用に向けたマイクロLEDアレイ搭載CMOS神経インターフェースデバイス
  • Author(s): 宮谷 友彰, Yosmongkol Sawadsaringkarn, 小林 琢磨, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: 応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
• [Presentation] in vitro およびin vivo オプトジェネティクス向け光刺激・イメージングデバイス
  • Author(s): 徳田 崇, 宮谷 友彰, Yosmongkol Sawadsaringkarn, 前澤 安代, 小林 琢磨, 野田 俊彦, 笹川 清隆, 太田 淳
  • Organizer: 日本神経科学大会
  • Place of Presentation: 名古屋国際会議場