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Analysis of neural stem cell fate using whole genome methylation profile

Research Project

Project/Area Number 24700412
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fusional basic brain science
Research InstitutionKyushu University (2013)
Nara Institute of Science and Technology (2012)

Principal Investigator

SANOSAKA Tsukasa  九州大学, 医学(系)研究科(研究院), 研究員 (40588472)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsエピジェネティクス / DNAメチル化 / 神経幹細胞
Research Abstract

In this research, I analyzed property of neural stem cell, which change during development comparing methylation status.I collected neural stem cells from different stage (Enbryonic day 11, 14, 18) of mouse brain and differentiated cells such as neuron, astrocyte and oligodendrocyte for whole genome methylation analysis. I identified the differentially methylated region of each cell type and transcription factor binding site.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2013

All Presentation (2 results) Book (2 results)

  • [Presentation] 発生進行に伴う神経幹細胞のDNAメチル化変動と遺伝子発現解析2013

    • Author(s)
      佐野坂司,三浦史仁,五十嵐勝秀,藤井信之,森山紀子,菅野純,池尾一穂,伊藤隆司,中島欽一
    • Organizer
      第7回エピジェネティクス研究会
    • Place of Presentation
      奈良県
    • Related Report
      2013 Final Research Report
  • [Presentation] 発生進行に伴う神経幹細胞のDNAメチル化変動と遺伝子発現解析2013

    • Author(s)
      佐野坂司、三浦史仁、五十嵐勝秀、藤井信之、森山紀子、菅野純、池尾一穂、伊藤隆司、中島欽一
    • Organizer
      第7回日本エピジェネティクス研究会年会
    • Place of Presentation
      奈良
    • Related Report
      2013 Annual Research Report
  • [Book] 脳神経科学イラストレイテッド(多能性幹細胞からの神経分化)改訂第3版2013

    • Author(s)
      佐野坂司,中島欽一
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] 改訂第3版 脳神経科学イラストレイテッド2013

    • Author(s)
      佐野坂司、中島欽一
    • Total Pages
      8
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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