| Project/Area Number |
24700415
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Fusional basic brain science
|
|---|
| Research Institution | Tokyo Metropolitan Institute of Medical Science |
|---|
Principal Investigator |
MATSUNO Motomi 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主席研究員 (90392365)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | グリア / ショウジョウバエ / 長期記憶 / 遺伝子 / 長期記憶形成 / 神経・グリア相互作用 |
|---|
| Research Abstract |
The molecular mechanisms underlying neuron-glia interaction during memory formation are poorly understood. Previously we discovered that a cell adhesion molecule, Klingon (Klg), is expressed in both neurons and glia, and a training-dependent increase in Klg-mediated neuron-glia interactions is required to form long-term memory (LTM). We also found that Klg modulates glial gene expression, which is required for LTM formation. In this study we identified a novel mechanism for glial regulation of LTM formation. We determined that Klg mediates interactions between specific types of neurons and glia, and found that these interactions increase expression of a glial transcription factor, Repo. Repo, in turn, activates a glial gene expression that functions to prevent LTM-induced cell death.
|
