The molecular mechanisms underlying neuron-glia interaction during long-term memory formation

• Project/Area Number: 24700415
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Fusional basic brain science
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: MATSUNO Motomi 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主席研究員 (90392365)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: グリア / ショウジョウバエ / 長期記憶 / 遺伝子 / 長期記憶形成 / 神経・グリア相互作用

Research Abstract

The molecular mechanisms underlying neuron-glia interaction during memory formation are poorly understood. Previously we discovered that a cell adhesion molecule, Klingon (Klg), is expressed in both neurons and glia, and a training-dependent increase in Klg-mediated neuron-glia interactions is required to form long-term memory (LTM). We also found that Klg modulates glial gene expression, which is required for LTM formation. In this study we identified a novel mechanism for glial regulation of LTM formation. We determined that Klg mediates interactions between specific types of neurons and glia, and found that these interactions increase expression of a glial transcription factor, Repo. Repo, in turn, activates a glial gene expression that functions to prevent LTM-induced cell death.

Research Products

• [Journal Article] Saitoe M Fasting launches CRTC to facilitate long-term memory formation in Drosophila (2013)
  • Author(s): Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, Horiuchi J
  • Journal Title: Science Volume: 339(6118) Pages: 443-446
  • Peer Reviewed
• [Journal Article] Fasting launches CRTC to facilitate long-term memory formation in Drosophila. (2013)
  • Author(s): Hirano, Y., Masuda, T., Naganos, S., Matsuno, M., Ueno, K., Miyashita, T., Horiuchi, J., Saitoe, M.
  • Journal Title: Science Volume: 339 Issue: 6118 Pages: 443-446
  • DOI: 10.1126/science.1227170
  • Peer Reviewed
• [Presentation] 長期記憶形成に必要なグリア転写因子Repoによる遺伝子発現 (2013)
  • Author(s): 松野元美
  • Organizer: 平成25年度生理研研究会「記憶回路研究会」
  • Place of Presentation: 岡崎(生理学研究所)
  • Year and Date: 2013-12-11
• [Presentation] Neuron-glial communication induces glial protein synthesis required for formation of long-term memories (2013)
  • Author(s): Motomi Matsuno, Junjiro Horiuchi, Minoru Saitoe
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2013-12-04
• [Presentation] Long-term memory formation requires neuron-glia signaling to induce protein synthesis (2013)
  • Author(s): Motomi Matsuno, Junjiro Horiuchi, Minoru Saitoe
  • Organizer: CSFN2013 Cell symposia-The Networked Brain
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2013-11-07
• [Presentation] Long-term memory formation requires neuron-glial signaling to induce protein synthesis (2013)
  • Author(s): Motomi Matsuno, Junjiro Horiuchi, Minoru Saito
  • Organizer: CSFN2013 Cell Symposia -The Networked Brain-
  • Place of Presentation: San Diego, USA
• [Presentation] Neuron-glial communication induces glial protein synthesis required for formation of long-term memories (2013)
  • Author(s): Motomi Matsuno, Junjiro Horiuchi, Minoru Saitoe
  • Organizer: 第３６回 日本分子生物学会
  • Place of Presentation: 神戸
• [Presentation] 長期記憶形成に必要なグリア転写因子Repoによる遺伝子発現 (2013)
  • Author(s): 松野 元美
  • Organizer: 平成２5年度生理研研究会 『記憶回路研究会』
  • Place of Presentation: 岡崎
  • Invited
• [Presentation] A neuron-glia communication underlying long-term memory formation (2012)
  • Author(s): Motomi Matsuno, Minoru Saitoe
  • Organizer: 第35回日本神経科学学会シンポジウム-Studying brain function in cellular resolution
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-19
• [Presentation] A neuron-glia communication underlying long-term memory formation.
  • Author(s): Motomi Matsuno, Minoru Saitoe
  • Organizer: 第３５回 日本神経科学学会 シンポジウム-Studying brain function in cellular resolution-
  • Place of Presentation: 名古屋