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Development of MEG-based neuroprosthetic arm and examination of cortical reorganization caused by reconstruction of motor function

Research Project

Project/Area Number 24700419
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fusional brain recording science
Research InstitutionOsaka University

Principal Investigator

YANAGISAWA Takufumi  大阪大学, 医学(系)研究科(研究院), 助教 (90533802)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsBrain-machine interface / 神経義手 / 脳磁図 / リハビリテーション / neuromodulation / 脳磁図による神経義手制御 / 非侵襲BMI / 重度麻痺患者へのBMI適用 / BMIによる脳可塑的変化 / 電動義手
Research Abstract

In this research, a novel neuroprosthetic arm was developed by acquiring neuromagnetic signals from clinical magnetoencepharography system and analyzing the data to extract motor information online. This system allowed some paralyzed patients to control the arm only by intending to move their paralyzed hand. Actually, the developed neuroprosthesis was applied for the patients with severe paralysis due to brachial plexus root avulsion, amyotrophic lateral sclerosis, stroke and cerebral palsy. The MEG signals were analyzed to extract motor information when the patients intended to move their paralyzed hand. Moreover, after training to use this neuroprosthesis, the brain activities of the patients were modulated to be appropriate for information extraction. These plastic changes suggests that the novel system has potential to be applied for rehabilitation of the severely paralyzed patients.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (41 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (22 results) (of which Invited: 3 results) Book (2 results) Remarks (7 results)

  • [Journal Article] Which is the Most Appropriate Disconnection Surgery for Refractory Epilepsy In Childhood?2013

    • Author(s)
      Kishima H, Oshino S, Tani N, Maruo Y, Morris S, Ming Khoo H, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T
    • Journal Title

      Neurol Med Chir(Tokyo)

      Volume: 53(11) Pages: 814-20

    • NAID

      10031196793

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cerebellar-related long latency motor response in upper limb musculature by transcranial magnetic stimulationof the cerebellum2013

    • Author(s)
      Hosokawa S, Hirata M, Goto T, Yanagisawa T, Sugata H, Araki T, Okamura Y, Hasegawa Y, Shinshi M, Yorifuji S
    • Journal Title

      Neuroreport

      Volume: 25(6) Pages: 353-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prediction of Three-Dimensional Arm Trajectories Based on ECoG Signals Recorded from Human Sensorimotor cortex2013

    • Author(s)
      Nakanishi Y, Yanagisawa T, Shin D, Fukuma R, Chen C, Kambara H, Hirata M, Yoshimine T, Koike Y
    • Journal Title

      PLoS One

      Volume: 8(8)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prediction of Three-Dimensional Arm Trajectories Based on ECoG Signals Recorded from Human Sensorimotor Cortex2013

    • Author(s)
      Yasuhiko Nakanishi, Takufumi Ynagisawa, Duk Shin, Ryohei Fukuma, Chao Chen, Hiroyuki Kambara, Natsue Yoshimura, Masayuki Hirata, Toshiki Yoshimine, Yasuharu Koike
    • Journal Title

      PLoS ONE

      Volume: VOL.8 Issue: 8 Pages: 1-9

    • DOI

      10.1371/journal.pone.0072085

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of motor representation by phase-amplitude coupling in the sensorimotor cortex2012

    • Author(s)
      Yanagisawa T, Yamashita O, Hirata M, Kishima H, Saitoh Y, Goto T, Yoshimine T, Kamitani Y
    • Journal Title

      J Neurosci

      Volume: 32(44) Pages: 15467-75

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regulation of Motor Representation by Phase-Amplitude Coupling in the Sensorimotor Cortex2012

    • Author(s)
      Takufumi Yanagisawa, Okito Yamashita, Masayuki Hirata, Haruhiko Kishima, Youichi Saitoh, Tetsu Goto, Toshiki Yoshimine, and Yukiyasu Kamitani
    • Journal Title

      The Journal of Neuroscience

      Volume: 32(44) Issue: 44 Pages: 15467-15475

    • DOI

      10.1523/jneurosci.2929-12.2012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural decoding of unilateral upper limb movements using single trial MEG signals.2012

    • Author(s)
      Sugata H
    • Journal Title

      Brain Res

      Volume: 1468 Pages: 29-37

    • DOI

      10.1016/j.brainres.2012.05.053

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用2012

    • Author(s)
      柳澤琢史
    • Journal Title

      認知神経科学

      Volume: 13(3) Pages: 255-260

    • NAID

      10031136830

    • Related Report
      2012 Research-status Report
  • [Journal Article] Movement-related neuromagnetic fields and performances of single trial classifications2011

    • Author(s)
      Sugata Hisato
    • Journal Title

      Neuroreport

      Volume: 23(1) Issue: 1 Pages: 16-20

    • DOI

      10.1097/wnr.0b013e32834d935a

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electrocorticographic control of a prosthetic arm in paralyzed patients2011

    • Author(s)
      Yanagisawa T
    • Journal Title

      Ann Neurol.

      Volume: 4(Epub ahead of print) Issue: 3 Pages: 353-361

    • DOI

      10.1002/ana.22613

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Neuroprosthetic arm using MEG signals of paralyzed patients2014

    • Author(s)
      T. Yanagisawa, R. Fukuma, M. Hirata, K.Matsushita, H. Kishima, Y. Saitoh, R. Kato, T. Seki, H. Sugata, H. Yokoi, Y. Kamitani, T. Yoshimine
    • Organizer
      ICCN2014
    • Place of Presentation
      ベルリン(口演)
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] BMI神経義手による新たなニューロ・モジュレーション2014

    • Author(s)
      栁澤琢史、福間良平、平田雅之、齋藤洋一、貴島晴彦、押野悟、菅田陽怜、松下光次郎、神谷之康、吉峰俊樹
    • Organizer
      日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場(口演)
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuroprosthetic arm using MEG signals of paralyzed patients2014

    • Author(s)
      Takufumi Yanagisawa, Ryouhei Fukuma, Masayuki Hirata, Kojiro Matsushita, Haruhiko Kishima, Youichi Saitoh, Ryu Kato, Tatsuya Seki, Hisato Sugata, Hiroshi Yokoi, Yukiyasu Kamitani, Toshiki Yoshimine
    • Organizer
      Inernational conference of clinicial neurophysiology 2014
    • Place of Presentation
      ドイツ、ベルリン
    • Related Report
      2013 Annual Research Report
  • [Presentation] BMI神経義手による新たなニューロ・モジュレーション2014

    • Author(s)
      栁澤琢史、福間良平、平田雅之、齋藤洋一、貴島晴彦、押野悟、菅田陽怜、松下光次郎、神谷之康、吉峰俊樹
    • Organizer
      日本定位・機能神経外科学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳磁図によるBCI/BMI2013

    • Author(s)
      栁澤琢史
    • Organizer
      臨床神経生理学学会
    • Place of Presentation
      高知(口演、脳磁図コンソーシアム(electa主催))
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Brain machine interfaceによる神経機能の補填と修飾2013

    • Author(s)
      栁澤琢史
    • Organizer
      近畿理学療法学術大会
    • Place of Presentation
      京都(依頼講演)
    • Year and Date
      2013-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] リアルタイム脳磁計を用いたBMIによる神経義手制御2013

    • Author(s)
      柳澤琢史、福間良平、松下光次郎、平田雅之、菅田陽怜、貴島晴彦、齋藤洋一、シェインモリス、神谷之康、吉峰俊樹
    • Organizer
      日本定位・機能神経外科学会
    • Place of Presentation
      岡山(口演)
    • Year and Date
      2013-01-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Real-time prosthetic arm control using MEG signals of paralyzed patients2013

    • Author(s)
      T. Yanagisawa, R. Fukuma, K. Matsushita, H. Kishima, Y. Saitoh, M. Hirata, R. Kato, T. Seki, H. Sugata, H. Yokoi, Y. Kamitani, T. Yoshimine
    • Organizer
      Society for neuroscience
    • Place of Presentation
      SanDiego(poster)
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動機能障害に対する神経義手を用いたニューロフィードバック療法2013

    • Author(s)
      栁澤琢史、福間良平、平田雅之、齋藤洋一、貴島晴彦、押野悟、菅田陽怜、松下光次郎、神谷之康、吉峰俊樹
    • Organizer
      日本脳神経外科学総会
    • Place of Presentation
      東京(口演)
    • Related Report
      2013 Final Research Report
  • [Presentation] Deteriorated phase-amplitude coupling on sensorimotor cortices of paralyzed patients2013

    • Author(s)
      T. Yanagisawa, O. Yamashita, M. Hirata, H. Kishima, Y. Saitoh, Y. Kamitani, T. Yoshimine
    • Organizer
      日本神経科学会
    • Place of Presentation
      国立京都国際会議場(口演)
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動機能障害患者に対するMEG-BMIによる神経義手の適用2013

    • Author(s)
      柳澤琢史、福間良平、平田雅之、貴島晴彦、押野悟、齋藤洋一、菅田陽怜、松下光次郎、シェインモリス、神谷之康、吉峰俊樹
    • Organizer
      日本生体磁気
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] Real-time prosthetic arm control using MEG signals of paralyzed patients2013

    • Author(s)
      Takufumi Yanagisawa, Ryouhei Fukuma, Kojiro Matsushita, Haruhiko Kishima, Youichi Saitoh, Masayuki Hirata, Ryu Kato, Tatsuya Seki, Hisato Sugata, Hiroshi Yokoi, Yukiyasu Kamitani, Toshiki Yoshimine
    • Organizer
      Society for neuroscience
    • Place of Presentation
      SanDiego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳磁図によるBCI/BMI2013

    • Author(s)
      栁澤琢史
    • Organizer
      臨床神経生理学学会、脳磁図コンソーシアム
    • Place of Presentation
      高知
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Brain machine interfaceによる神経機能の補填と修飾2013

    • Author(s)
      栁澤琢史
    • Organizer
      近畿理学療法学術大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 運動機能障害患者に対するMEG-BMIによる神経義手の適用2013

    • Author(s)
      柳澤琢史、福間良平、平田雅之、貴島晴彦、押野悟、齋藤洋一、菅田陽怜、松下光次郎、シェインモリス、神谷之康、吉峰俊樹
    • Organizer
      日本生体磁気学会
    • Place of Presentation
      新潟コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] Electrocorticographic control of a prosthetic arm in paralyzed patients2012

    • Author(s)
      Takufumi Yanagisawa, Masayuki Hirata, Youichi Saitoh, Haruhiko Kishima, Kojiro Matsushita, Tetsu Goto, Ryohei Fukuma, Hiroshi Yokoi, Yukiyasu Kamitani
    • Organizer
      BMI OSAKA
    • Place of Presentation
      大阪国際会議場(poster)
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] リアルタイム脳磁計を用いたBMIによる神経義手制御2012

    • Author(s)
      柳澤琢史、福間良平、松下光次郎、平田雅之、菅田陽怜、貴島晴彦、齋藤洋一、押野悟、圓尾知之、シェインモリス、影山悠、クーウィミン、後藤雄子、神谷之康、吉峰俊樹
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      大阪国際会議場(口演)
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Modulation of motor representation by alpha oscillation through phase-amplitude coupling2012

    • Author(s)
      Takufumi Yanagisawa, Okito Yamashita, Masayuki Hirata, Haruhiko Kishima, Youichi Saitoh, Tetsu Goto, Morris Shayne, Toshiki Yoshimine, Yukiyasu Kamitani
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋(口演)
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] リアルタイム脳磁計を用いたBMIによる神経義手制御

    • Author(s)
      柳澤琢史、福間良平、松下光次郎、平田雅之、菅田陽怜、貴島晴彦、齋藤洋一、シェインモリス、神谷之康、吉峰俊樹
    • Organizer
      第52回日本定位・機能神経外科学会
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
  • [Presentation] Electrocorticographic control of a prosthetic arm in paralyzed patients

    • Author(s)
      Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Matsushita K, Goto T, Fukuma R, Yokoi H, Kamitani Y
    • Organizer
      BMI OSAKA
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] リアルタイム脳磁計を用いたBMIによる神経義手制御

    • Author(s)
      柳澤琢史、福間良平、松下光次郎、平田雅之、菅田陽怜、貴島晴彦、齋藤洋一、押野悟、圓尾知之、シェインモリス、影山悠、クーウィミン、後藤雄子、神谷之康、吉峰俊樹
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] Modulation of motor representation by alpha oscillation through phase-amplitude coupling

    • Author(s)
      Yanagisawa T, Yamashita O, Hirata M, Kishima H, Saitoh Y, Goto T, Morris S , Yoshimine T, Kamitani Y
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Book] ブレインサイエンス・レビュー2014、脳磁計による神経義手のALS患者への適応(栁澤琢史、編集(公財)ブレインサイエンス振興財団)2014

    • Author(s)
      廣川信隆
    • Publisher
      クバプロ
    • Related Report
      2013 Final Research Report
  • [Book] ブレインサイエンス・レビュー 20142014

    • Author(s)
      栁澤琢史
    • Total Pages
      19
    • Publisher
      クバプロ
    • Related Report
      2013 Annual Research Report
  • [Remarks] 公開シンポジウム 平成25年2月1日、学術総合センター、第5回脳プロ公開シンポジウム「基礎研究が支える脳科学」にて「日本の特長を活かしたBMIの統合的研究開発」に関するポスター受賞

    • Related Report
      2013 Final Research Report
  • [Remarks] 平成25年4月16日 平成25年度 科学技術分野の文部科学大臣表彰若手 科学者賞受賞、麻痺患者の皮質脳波による神経義手の開発、栁澤琢史 受賞

    • Related Report
      2013 Final Research Report
  • [Remarks] 平成25年1月18日、大阪大学総長表彰、"日本医師会医学研究奨励賞"受賞に関連して、栁澤琢史 受賞

    • Related Report
      2013 Final Research Report
  • [Remarks] 2013年6月25日、日本経済新聞夕刊 現場百景 報道

    • Related Report
      2013 Final Research Report
  • [Remarks] 2013年4月11日、朝7:20-7:30, NHK総合テレビ、おはよう日本「けさのクローズアップ」コーナー 報道

    • Related Report
      2013 Final Research Report
  • [Remarks] 2012年4月10日掲載、朝日新聞、「脳波を感知義手やマウス動かせたら…」 報道

    • Related Report
      2013 Final Research Report
  • [Remarks] 「ブレイン・マシン・インターフェースを用いた脳機能再建の研究」

    • URL

      http://www.nsurg.med.osaka-u.ac.jp/school/research/research.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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