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Basic and clinical study on inhibitory modulation of motor function using a regulatory focal brain cooling

Research Project

Project/Area Number 24700420
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fusional brain recording science
Research InstitutionYamaguchi University

Principal Investigator

IMOTO HIROCHIKA  山口大学, 医学部附属病院, 診療助教 (80464337)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳機能計測 / 局所脳冷却 / 脳機能マッピング / マイクロダイアリシス
Research Abstract

The neurosurgical treatment for diseases such as intractable epilepsy and brain tumors, functional localization of the brain is evaluated by functional brain mapping. However, There is a problem such as accidentally induced convulsion by electrical stimulation. In this study, we investigated the effects on brain function by focal brain cooling.
As a result, the boundary of the cooling temperature to cause dysfunction, was 10-15 degC. Further, if the cooling at 15 degC does not cause loss of function, brain function was not disrupted. Therefore, the focal brain cooling is reversible brain function control method could be confirmed.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] Changes in glutamate concentration, glucose metabolism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans2014

    • Author(s)
      Sadahiro Nonura, Masami Fujii, Takao Inoue, Yeting He, Yuichi Maruta, Hiroyasu Koizumi, Eiichi Suehiro, Hirochika Imoto, Hideyuki Ishihara, Fumiaki Oka, Mishiya Matsumoto, Yuji Owada, Takeshi Yamakawa, and Michiyasu Suzuki
    • Journal Title

      Epilepsia

      Volume: Vol.55(5) Issue: 5 Pages: 770-776

    • DOI

      10.1111/epi.12600

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in glutamate concentration, glucose metablism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans2014

    • Author(s)
      Sadahiro Nonura, Masami Fujii, Takao Inoue,Yeting He, Yuichi Maruta, Hiroyasu Koizumi, Eiichi Suehiro, Hirochika Imoto, Hideyuki Ishihara, Fumiaki Oka, Mishiya Matsumoto, Yuji Owada, Takeshi Yamakawa, and Michiyasu Suzuki
    • Journal Title

      Epilepsia

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 難治性複雑部分発作を呈した島回部2012

    • Author(s)
      井本浩哉、藤井正美、丸田雄一、貞廣浩和、出口誠、石原秀行、野村貞宏、鈴木倫保
    • Journal Title

      脳神経外科

      Volume: Vol.40 Pages: 799-804

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 光トポグラフィー装置を用いた無侵襲言語優位半球の同定法について~Wada testとの比較~2012

    • Author(s)
      丸田雄一、藤井正美、野村貞宏、井本浩哉、岡史朗、出口誠、吉川功一、米田浩、石原秀行、山川烈、鈴木倫保
    • Journal Title

      臨床神経生理学

      Volume: Vol.40 Pages: 519-526

    • NAID

      10031159684

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 難治性複雑部分発作を呈した島回部2012

    • Author(s)
      井本浩哉、藤井正美、丸田雄一、貞廣浩和、出口 誠、石原秀行、野村貞宏、鈴木倫保
    • Journal Title

      脳神経外科

      Volume: 40 Pages: 799-804

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 光トポグラフィー装置を用いた無侵襲言語優位半球の同定法について~Wada testとの比較~2012

    • Author(s)
      丸田雄一、藤井正美、野村貞宏、井本浩哉、岡 史朗、出口 誠、吉川功一、米田 浩、石原秀行、山川 烈、鈴木倫保
    • Journal Title

      臨床神経生理学

      Volume: 40 Pages: 519-526

    • NAID

      10031159684

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 機能神経外科の新たなアプローチ : Thermal Neuromodulation2012

    • Author(s)
      藤井正美、井上貴雄、賀業霆、丸田雄一、井本浩哉、田中信宏、奥高行、藤岡裕士、米田浩、小泉博靖、野村貞宏、鈴木倫保
    • Organizer
      日本脳神経外科学会第71回学術総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 透過における長期脳波ビデオモニタリングの記録と解析における工夫2012

    • Author(s)
      丸田雄一、藤井正美、井本浩哉、野村貞宏、五島久陽、田中信宏、貞廣浩和、末廣栄一、米田浩、鈴木倫保
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京(都市センターホテル)
    • Year and Date
      2012-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 痙縮に対する脊髄刺激療法の効果2012

    • Author(s)
      井本浩哉、藤井正美、丸田雄一、野村貞宏、鈴木倫保
    • Organizer
      第26開日本ニューロモデュレーション学会
    • Place of Presentation
      東京(都市センターホテル)
    • Year and Date
      2012-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 痙縮に対する脊髄刺激療法の効果2012

    • Author(s)
      井本浩哉、藤井正美、丸田雄一、野村貞宏、鈴木倫保
    • Organizer
      第26回日本ニューロモデュレーション学会
    • Place of Presentation
      都市センターホテル、東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 当科における長期脳波ビデオモニタリングの記録と解析における工夫2012

    • Author(s)
      丸田雄一、藤井正美、井本浩哉、野村貞宏、五島久陽、田中信宏、貞廣浩和、末廣栄一、米田 浩、鈴木倫保
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      都市センターホテル、東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 機能神経外科の新たなアプローチ:Thermal neuromodulation2012

    • Author(s)
      藤井正美、井上貴雄、賀 業霆、丸田雄一、井本浩哉、田中信宏、奥 高行、藤岡裕士、米田 浩、小泉博靖、野村貞宏、鈴木倫保
    • Organizer
      日本脳神経外科学会 第71回学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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