Basic and clinical study on inhibitory modulation of motor function using a regulatory focal brain cooling
Project/Area Number |
24700420
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Fusional brain recording science
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Research Institution | Yamaguchi University |
Principal Investigator |
IMOTO HIROCHIKA 山口大学, 医学部附属病院, 診療助教 (80464337)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 脳機能計測 / 局所脳冷却 / 脳機能マッピング / マイクロダイアリシス |
Research Abstract |
The neurosurgical treatment for diseases such as intractable epilepsy and brain tumors, functional localization of the brain is evaluated by functional brain mapping. However, There is a problem such as accidentally induced convulsion by electrical stimulation. In this study, we investigated the effects on brain function by focal brain cooling. As a result, the boundary of the cooling temperature to cause dysfunction, was 10-15 degC. Further, if the cooling at 15 degC does not cause loss of function, brain function was not disrupted. Therefore, the focal brain cooling is reversible brain function control method could be confirmed.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Changes in glutamate concentration, glucose metabolism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans2014
Author(s)
Sadahiro Nonura, Masami Fujii, Takao Inoue, Yeting He, Yuichi Maruta, Hiroyasu Koizumi, Eiichi Suehiro, Hirochika Imoto, Hideyuki Ishihara, Fumiaki Oka, Mishiya Matsumoto, Yuji Owada, Takeshi Yamakawa, and Michiyasu Suzuki
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Journal Title
Epilepsia
Volume: Vol.55(5)
Issue: 5
Pages: 770-776
DOI
Related Report
Peer Reviewed
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[Journal Article] Changes in glutamate concentration, glucose metablism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans2014
Author(s)
Sadahiro Nonura, Masami Fujii, Takao Inoue,Yeting He, Yuichi Maruta, Hiroyasu Koizumi, Eiichi Suehiro, Hirochika Imoto, Hideyuki Ishihara, Fumiaki Oka, Mishiya Matsumoto, Yuji Owada, Takeshi Yamakawa, and Michiyasu Suzuki
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Journal Title
Related Report
Peer Reviewed
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[Presentation] 痙縮に対する脊髄刺激療法の効果2012
Author(s)
井本浩哉、藤井正美、丸田雄一、野村貞宏、鈴木倫保
Organizer
第26開日本ニューロモデュレーション学会
Place of Presentation
東京(都市センターホテル)
Year and Date
2012-05-26
Related Report
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