| Project/Area Number |
24700433
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
YAOITA FUKIE 東北薬科大学, 薬学部, 助教 (00382672)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ADHD / 衝動性 / 不注意 / 高架式十字迷路 / Y字迷路 / 睡眠 / 断眠 / 注意欠陥／多動性障害 / 交替率 / レム睡眠 |
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| Research Abstract |
Attention deficit/hyperactivity disorder (ADHD) is a childhood psychiatric disorder characterized by the presence of symptoms in three domains: inattention, impulsivity, and motor overactivity. On the other hand, there are evidences to suggest children in the ADHD group had shorter duration of REM sleep and total sleep duration than control. We have previously shown that abnormal behaviors elicited by intermittent sleep deprivation (SD) treatment may fulfill a hyperactive feature of ADHD model animals. In this study, we investigated the influences of the SD treatment on the Y-maze test and the elevated plus maze test, indicating an effect on inattentive and impulsive features of ADHD model animals, respectively. We found that both tests were influenced by SD treatment. Moreover, the impaired behaviors were significantly attenuated by methylphenidate, which is used clinically to treat ADHD symptoms. Therefore, the SD mice can be useful model for elucidation of the mechanism of ADHD.
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