Establishment of attention-deficit/hyperactivity disorder animal model by intermittent REM sleep deprivation

• Project/Area Number: 24700433
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Tohoku Pharmaceutical University
• Principal Investigator: YAOITA FUKIE 東北薬科大学, 薬学部, 助教 (00382672)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ADHD / 衝動性 / 不注意 / 高架式十字迷路 / Y字迷路 / 睡眠 / 断眠 / 注意欠陥／多動性障害 / 交替率 / レム睡眠

Research Abstract

Attention deficit/hyperactivity disorder (ADHD) is a childhood psychiatric disorder characterized by the presence of symptoms in three domains: inattention, impulsivity, and motor overactivity. On the other hand, there are evidences to suggest children in the ADHD group had shorter duration of REM sleep and total sleep duration than control. We have previously shown that abnormal behaviors elicited by intermittent sleep deprivation (SD) treatment may fulfill a hyperactive feature of ADHD model animals. In this study, we investigated the influences of the SD treatment on the Y-maze test and the elevated plus maze test, indicating an effect on inattentive and impulsive features of ADHD model animals, respectively. We found that both tests were influenced by SD treatment. Moreover, the impaired behaviors were significantly attenuated by methylphenidate, which is used clinically to treat ADHD symptoms. Therefore, the SD mice can be useful model for elucidation of the mechanism of ADHD.

Research Products

• [Journal Article] Influence of a long-term powdered diet on the social interaction test and dopaminergic systems in mice (2013)
  • Author(s): Fukie Niijima-Yaoita, Masahiro Tsuchiya, Hiroko Saito, Yuka Nagasawa, Shigeo Murai, Yuichiro Arai, Osamu Nakagawasai, Wataru Nemoto, Takeshi Tadano, Koichi Tan-No
  • Journal Title: Neurochemistry International Volume: 63 Pages: 309-315
  • Peer Reviewed
• [Journal Article] Yasuo Endo Roles played by histamine in strenuous or prolonged masseter muscle activity in mice (2013)
  • Author(s): Hiroyuki Yoneda, Fukie Niijima-Yaoita, Masahiro Tsuchiya, Hiroyuki Kumamoto, Makoto Watanabe, Hiroshi Ohtsu, Kazuhiko Yanai, Takeshi Tadano, Keiichi Sasaki, Shunji Sugawara
  • Journal Title: Clinical and Experimental Pharmacology and Physiology Volume: 40 Pages: 848-855
  • Peer Reviewed
• [Journal Article] Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice (2013)
  • Author(s): Nemoto W ., Sato T ., Nakagawasai O., Yaoita F ., Silberring J., Tadano T , Tan-No K
  • Journal Title: Neuropeptides Volume: 47 Issue: 3 Pages: 187-191
  • DOI: 10.1016/j.npep.2012.11.002
  • Peer Reviewed
• [Journal Article] Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice (2013)
  • Author(s): Wataru Nemoto, Osamu Nakagawasai, Fukie Yaoita, Syu-Ichi Kanno, Shin Yomogida, Masaaki Ishikawa, Takeshi Tadano, Koichi Tan-No
  • Journal Title: Mol. Pain Volume: 9 Pages: 38-38
  • NAID: 120005328804
  • Peer Reviewed
• [Journal Article] Influence of a long-term powdered diet on the social interaction test and dopaminergic systems in mice. (2013)
  • Author(s): Niijima-Yaoita F, Tsuchiya M, Saito H, Nagasawa Y, Murai S, Arai Y, Nakagawasai O, Nemoto W, Tadano T, Tan-No K.
  • Journal Title: Neurochem Int. Volume: 63 Issue: 4 Pages: 309-315
  • DOI: 10.1016/j.neuint.2013.07.004
  • Peer Reviewed
• [Journal Article] Roles played by histamine in strenuous or prolonged masseter muscle activity in mice. (2013)
  • Author(s): Yoneda H, Niijima-Yaoita F, Tsuchiya M, Kumamoto H, Watanabe M, Ohtsu H, Yanai K, Tadano T, Sasaki K, Sugawara S, Endo Y.
  • Journal Title: Clin Exp Pharmacol Physiol. Volume: 40 Issue: 12 Pages: 848-855
  • DOI: 10.1111/1440-1681.12167
  • Peer Reviewed
• [Presentation] 断続的断眠ストレスによる過敏性腸症候群動物モデルの作製 (2014)
  • Author(s): 八百板富紀枝
  • Place of Presentation: 仙台
  • Year and Date: 2014-03-20
• [Presentation] 断続的断眠ストレス負荷誘発性腸管輸送能亢進状態におけるα2アドレナリン受容体の関与 (2013)
  • Author(s): 八百板富紀枝、下道麻夏、荒井香、齊藤貴之、根本亙、中川西修、只野武、丹野孝一
  • Organizer: 第64回日本薬理学会北部会
  • Place of Presentation: 旭川
  • Year and Date: 2013-09-13
• [Presentation] 粉末食飼育はマウスの糖代謝機構を障害し、行動異常を誘発する (2013)
  • Author(s): 千葉航、土谷昌広、八百板富紀枝、米田博行、渡邉誠、佐々木啓一、坪井明人、服部佳功
  • Organizer: 日本老年歯科医学会第24回学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2013-06-04
• [Presentation] 粉末食飼育マウスにおけるSocial interactionの障害について (2013)
  • Author(s): 八百板富紀枝、荒井香、下道麻夏、齊藤貴之、土谷昌広、斉藤弘子、村井繁夫、荒井裕一朗、根本亙、中川西修、只野武、丹野孝一
  • Organizer: 平成25年度東北薬科大学創薬研究センターシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2013-05-25
• [Presentation] メチルフェニデートの自発的交替行動障害改善効果における一酸化窒素合成酵素の関与 (2013)
  • Author(s): 八百板富紀枝、永澤佑佳、齊藤貴之、荒井香、下道麻夏、土谷昌広、根本亙、中川西修、荒井裕一朗、只野武、丹野孝一
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-23
• [Presentation] 粉末食飼育マウスにおけるSocial interactionの障害について (2013)
  • Author(s): 八百板富紀枝、荒井香、下道麻夏、齊藤貴之、土谷昌広、斉藤弘子、村井繁夫、荒井裕一朗、根本亙、中川西修，只野武、丹野孝一
  • Organizer: 平成２５年度東北薬科大学創薬研究センターシンポジウム
  • Place of Presentation: 仙台
• [Presentation] 粉末食飼育はマウスの糖代謝機構を障害し、行動異常を誘発する (2013)
  • Author(s): 千葉航、土谷昌広、八百板富紀枝、米田博行、渡邉誠、佐々木啓一、坪井明人、服部佳功
  • Organizer: 日本老年歯科医学会第２４回学術大会
  • Place of Presentation: 大阪
• [Presentation] 断続的断眠ストレス負荷誘発性マウス腸管輸送能亢進状態におけるα2アドレナリン受容体の関与 (2013)
  • Author(s): 八百板富紀枝、下道麻夏、荒井香、齊藤貴之、根本亙、中川西修、只野武、丹野孝一
  • Organizer: 第64回日本薬理学会北部会
  • Place of Presentation: 旭川
• [Presentation] Effect of methylphenidate on L-NAME-induced behavioral impairment in Y-maze task in mice (2013)
  • Author(s): Fukie Yaoita, Yuka Nagasawa, Takayuki Saito, Kaori Arai, Asaka Shitamichi, Masahiro Tsuchiya, Wataru Nemoto, Osamu Nakagawasai, Yuichiro Arai, Takeshi Tadano, Koichi Tan-No
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
• [Remarks]
  • URL: http://www.tohoku-pharm.ac.jp/laboratory/yakuri/