Quantification of physiological parameters in brain PET: partial volume correction and denoising

• Project/Area Number: 24700445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: SHIDAHARA Miho 東北大学, 医学(系)研究科(研究院), 講師 (20443070)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳PET / 画像処理 / 動態解析 / PET / 脳 / 機能画像 / 形態画像 / 脳機能推定 / 定量解析

Outline of Final Research Achievements

Towards more accurate estimation of physiological brain function using PET, we developed the methodology SFS-RR (structural and functional synergy for resolution recovery), which improves image quality (both resolution and quantification) of PET image by using Wavelet transform and anatomical/structural information (MRI and brain atlas images). We evaluate the performance of the recovery strategy in the case of the quantification of dopaminegic function in striatal regions. The proposed methodology proved effective in the resolution recovery of small structures of brain [11C]raclopride PET images and the improvement is consistent across the anatomical variability of a simulated population (Shidahara et al, 2012).

Research Products

• [Journal Article] Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect (2013)
  • Author(s): McGinnity CJ, Shidahara M, Feldmann M, Keihaninejad S, Riano Barros DA, Gousias IS, Duncan JS, Brooks DJ, Heckemann RA, Turkheimer FE, Hammers A, Koepp MJ.
  • Journal Title: Neuroimage Volume: 79 Pages: 72-80
  • DOI: 10.1016/j.neuroimage.2013.04.015
  • Peer Reviewed
• [Journal Article] Partial volume correction using structural-functional synergistic resolution recovery: comparison with geometric transfer matrix method. (2013)
  • Author(s): Kim E, Shidahara M, Tsoumpas C, McGinnity CJ, Kwon JS, Howes OD, Turkheimer FE.
  • Journal Title: J Cereb Blood Flow Metab Volume: 33(6) Issue: 6 Pages: 914-20
  • DOI: 10.1038/jcbfm.2013.29
  • Peer Reviewed
• [Journal Article] Turkheimer FE.Wavelet-based resolution recovery using an anatomical prior provides quantitative recovery for human population phantom PET [C-11]raclopride data. (2012)
  • Author(s): Shidahara M, Tsoumpas C, McGinnity CJ, Kato T, Tamura H, Hammers A, Watabe H
  • Journal Title: Phys Med Biol. Volume: 57(10) Issue: 10 Pages: 3107-22
  • DOI: 10.1088/0031-9155/57/10/3107
  • Peer Reviewed
• [Presentation] 早期アルツハイマー病診断を目的とした脳PET画像に対する部分容積効果補正法の基礎検討 (2014)
  • Author(s): 志田原美保
  • Organizer: 第54回日本核医学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-11-13
• [Remarks] PET脳画像のソフトウェアの無償公開
  • URL: http://www.noninvasive.med.tohoku.ac.jp/ShidaharaLab/SFSRR.html
• [Remarks] SFSRRソフトウェア
  • URL: http://www.noninvasive.med.tohoku.ac.jp/ShidaharaLab/SFSRR.html