| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Autonomic nervous system, which controls pupillary behaviors, might be damaged by stressors. We developed the monitoring methods of the nervous system and the circadian rhythms of several autonomic functions by using pupillary analyses. We used blue (470nm) and red (640nm) light stimuli for inducing of pupillary light responses. The blue light especially stimulates the melanopsin-expressing retinal ganglion cells (mRGCs), which contributes to the coordination of circadian rhythms. The pupillary response to the blue stimulation well correlated with heart rate variations and the response to the red light showed fine correlation with body temperature changes. These pupillary behaviors could be a maker for biological rhythms regulated by autonomic nervous system.
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