Biomarker discovery with wide targeted lipidomic profiling for early detection of colorectal cancer
| Project/Area Number |
24700455
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University (2013-2014)
Kobe University (2012) |
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Principal Investigator |
IZUMI Yoshihiro 大阪大学, 工学(系)研究科(研究院), 助教 (70622166)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | メタボロミクス / リピドミクス / 大腸がん / バイオマーカー探索 / 慢性炎症 / メタボローム解析 / 脂質 / バイオマーカー |
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| Outline of Final Research Achievements |
To improve the quality of life of colorectal cancer patients, it is important to establish new screening methods for early diagnosis of colorectal cancer. Lipids are fundamental constituents that structurally and chemically regulate cell membranes, store energy, and can become precursors to bioactive metabolites. We developed the comprehensive lipids profiling methodology and performed serum lipidomic analysis using liquid chromatography/tandem mass spectrometry (LC/MSMS). Wide targeted lpidomic profiling was not only provide insights into the specific roles of molecular species for enteritis and colorectal cancer, but also assist in identifying potential biomarkers for colorectal cancer.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages2013
Author(s)
Ohira H, Fujioka Y, Katagiri C, Mamoto R, Aoyama M, Izumi Y, Nishiumi S, Yoshida M, Usami M, Ikeda M.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 20
Issue: 5
Pages: 425-442
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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[Journal Article] A novel serum metabolomics-based diagnostic approach to pancreatic cancer.2013
Author(s)
Kobayashi T, Nishiumi S, Ikeda A, Yoshie T, Sakai1 A, Matsubara A, Izumi Y, Tsumura H, Tsuda M, Nishisaki H, Hayashi N, Kawano S, Fujiwara Y, Minami H, Takenawa T, Azuma T, Yoshida M.
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Journal Title
Cancer Epidem. Biomar.
Volume: 22(4)
Issue: 4
Pages: 571-579
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel serum metabolomics-based diagnostic approach for colorectal cancer.2012
Author(s)
Nishiumi S, Kobayashi T, Ikeda A, Yoshie T, Kibi M, Izumi Y, Okuno T, Hayashi N, Kawano S, Takenawa T, Azuma T, Yoshida M.
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Journal Title
PLoS ONE
Volume: 7(7)
Issue: 7
Pages: e40459-e40459
DOI
Related Report
Peer Reviewed
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