Prevention of implant related infection using titanium dioxide photocatalyst and ultrasound

Research Project

Project/Area Number	24700460
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Biomedical engineering/Biological material science
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	YOSHIDA Takashi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10546641)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	光触媒 / 細菌感染 / 超音波
Research Abstract	We found the anti-infectious effect of ultraviolet using titanium dioxide photocatalyst and apply it in the bedside. However, implant inside the body does not receive ultraviolet. Ultrasound can invade inside the body and can excite photocatalytic effect. The purpose of this study was to make the method of disinfection and decomposing biofilm using photocatalyst excited by ultrasound and to apply it in preventing early stage infection. It was difficult to settle the appropriate ultrasound strength without harmful effect. We researched clinical effect of titanium dioxide photocatalyst. We demonstrated that titanium dioxide photocatalyst prevent severe pin tract infection among the treatment using external fixation.