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Development of a hydrodynamically levitated centrifugal blood pump for an extra-corporeal circulation support

Research Project

Project/Area Number 24700468
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

KOSAKA Ryo  独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (10415680)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords人工心臓 / 動圧軸受 / 血液適合性 / 溶血 / 軸受剛性 / 数値流体解析 / 血液ポンプ / 流体軸受 / ラジアル軸受 / 溶血試験 / 軸受隙間 / 多円弧軸受
Outline of Final Research Achievements

We have developed a hydrodynamically levitated centrifugal pump for an extra-corporeal circulation support. In this study, we investigated an optimal geometry of hydrodynamic bearings in the developed blood pump for the reduction of hemolysis. In order to investigate the optimal geometry of the hydrodynamic bearings, we performed a numerical simulation based on Lubrication theory, a measurement test of the bearing gap using a laser displacement sensor and an in-vitro hemolysis test using bovine blood. As a result, in the radial bearing, the optimal parameter combination was found to be as follows: number of arcs 4, bearing clearance 90 μm, and groove depth 100 μm. This parameter combination achieved a large radial bearing gap and improved the hemolysis level. In the thrust bearing, the optimal geometry of the spiral groove was found to be the contraction model. This model achieved a large thrust bearing gap and improved the hemolysis level.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results) Presentation (30 results) (of which Invited: 2 results)

  • [Journal Article] Evaluation of a spiral groove geometry for improvement of hemolysis level in a hydrodynamically levitated centrifugal blood pump2015

    • Author(s)
      Murashige T, Kosaka R, Nishida M, Maruyama O, Kawaguchi Y, Yamane T
    • Journal Title

      Artif Organs

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Optimal bearing gap of a multi-arc radial bearing in a hydrodynamically levitated centrifugal blood pump for the reduction of hemolysis2014

    • Author(s)
      Kosaka R, Yasui K, Nishida M, Maruyama O, Kawaguchi Y, Yamane T
    • Journal Title

      Artif Organs

      Volume: 38 Issue: 9 Pages: 818-822

    • DOI

      10.1111/aor.12383

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Geometric Optimization of a Step Bearing for a Hydrodynamically Levitated Centrifugal Blood Pump for the Reduction of Hemolysis2013

    • Author(s)
      Kosaka R, Yada T, Nishida M, Maruyama O, K, Yamane T
    • Journal Title

      Artif Organs

      Volume: 37 (9) Issue: 9 Pages: 778-785

    • DOI

      10.1111/aor.12114

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimal design of the hydrodynamic multi-arc bearing in a centrifugal blood pump for the improvement of bearing stiffness and hemolysis level2013

    • Author(s)
      Yasui K, Kosaka R, Nishida M, Maruyama O, Kawaguchi Y, Yamane T.
    • Journal Title

      Artif Organs

      Volume: 37 (9) Issue: 9 Pages: 768-777

    • DOI

      10.1111/aor.12163

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluid dynamic design for low hemolysis in a hydrodynamically levitated centrifugal blood pump2013

    • Author(s)
      Murashige T, Kosaka R, Nishida M, Maruyama O, Yamane T, Kuwana K, Kawaguchi Y
    • Journal Title

      Proceedings of Engineering in Medicine and Biology Society (EMBC)

      Volume: 35 Pages: 2732-2735

    • DOI

      10.1109/embc.2013.6610105

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of a bearing gap on hemolysis property in a hydrodynamically levitated centrifugal blood pump with a semi-open impeller2013

    • Author(s)
      Kosaka R, Nishida M, Maruyama O, Yambe T, Imachi K, Yamane T
    • Journal Title

      BIO-MEDICAL MATERIALS AND ENGINEERING

      Volume: 23 Issue: 1-2 Pages: 37-47

    • DOI

      10.3233/bme-120730

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 心疾患患者を救命する補助循環血液ポンプの研究開発2015

    • Author(s)
      小阪 亮
    • Organizer
      産業技術総合研究所技術普及講演会
    • Place of Presentation
      アーバンプレイス(富山)
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 動圧軸受を用いた動圧浮上遠心血液ポンプの開発2014

    • Author(s)
      小阪 亮、迫田 大輔、西田 正浩、丸山 修、山根 隆志
    • Organizer
      医用アクチュエーション研究会
    • Place of Presentation
      産総研臨海センター(東京)
    • Year and Date
      2014-12-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 血液適合性改善を目的とした動圧浮上遠心血液ポンプのスパイラルグルーブ形状の検討2014

    • Author(s)
      村重 智崇、小阪 亮、迫田 大輔、西田 正浩、川口 靖夫、山根 隆志、丸山 修
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      京王プラザホテル札幌(北海道)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] In Vitro Evaluation of the Hemocompatibility in a Hydrodynamically Levitated Centrifugal Blood Pump2014

    • Author(s)
      Murashige T, Kosaka R, Sakota D, Nishida M, Kawaguchi Y, Yamane T, Maruyama O
    • Organizer
      22nd Congress of the International Society of Rotary Blood Pumps (ISRBP)
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Geometric Design of Spiral Groove Bearing to Reduce Hemolysis in a Hydrodynamically Levitated Centrifugal Blood Pump2014

    • Author(s)
      Murashige T, Kosaka R, Sakota D, Nishida M, Kawaguchi Y, Yamane T, Maruyama O
    • Organizer
      ASAIO 60th Annual Conference
    • Place of Presentation
      Washington D.C. (USA)
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optimal bearing gap of a multi-arc radial bearing in a hydrodynamically levitated centrifugal blood pump for the reduction of hemolysis2013

    • Author(s)
      Kosaka R, Yasui K, Nishida M, Maruyama O, Yamane T.
    • Organizer
      21st Congress of the International Society for Rotary Blood Pumps (ISRBP)
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] Fluid dynamic design for low hemolysis in a hydrodynamically levitated centrifugal blood pump2013

    • Author(s)
      Murashige T, Kosaka R, Nishida M, Maruyama O, Yamane T, Kuwana K, Kawaguchi Y
    • Organizer
      The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13)
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] Geometric Design of the Spiral Groove in a Hydrodynamically Levitated Centrifugal Blood Pump for the Improvement of the Impeller Levitation Performance2013

    • Author(s)
      Murashige T, Kosaka R, Nishida M, Sakota D, Maruyama O, Yamane T, Kawaguchi Y
    • Organizer
      21st Congress of the International Society for Rotary Blood Pumps (ISRBP)
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] インペラ浮上特性改善を目的とした動圧浮上遠心血液ポンプのスラスト軸受形状の検討2013

    • Author(s)
      村重 智崇、小阪 亮、西田 正浩、丸山 修、山根 隆志、桑名克之、川口 靖夫
    • Organizer
      LIFE2013 生活生命支援医療福祉工学系学会連合大会
    • Place of Presentation
      山梨大(甲府)
    • Related Report
      2013 Research-status Report
  • [Presentation] 動圧浮上遠心血液ポンプのスラスト軸受形状がインペラ浮上特性に与える影響2013

    • Author(s)
      村重 智崇、小阪 亮、迫田大輔、西田 正浩、丸山 修、山根 隆志、桑名克之、川口 靖夫
    • Organizer
      日本機械学会茨城講演会
    • Place of Presentation
      茨城大学(日立)
    • Related Report
      2013 Research-status Report
  • [Presentation] 動圧浮上遠心血液ポンプのスラスト軸受形状が定常流・拍動流下でのインペラ浮上特性に与える影響2013

    • Author(s)
      村重 智崇、小阪 亮、迫田大輔、西田 正浩、丸山 修、山根 隆志、桑名克之、川口 靖夫
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] 溶血低減を目的とした動圧浮上遠心血液ポンプのスラスト軸受形状の検討2013

    • Author(s)
      村重 智崇、小阪 亮、迫田大輔、西田 正浩、丸山 修、山根 隆志、桑名克之、川口 靖夫
    • Organizer
      第42回人工心臓と補助循環懇話会学術集会
    • Place of Presentation
      越後湯沢ナスパニューオータニ(新潟)
    • Related Report
      2013 Research-status Report
  • [Presentation] 動圧浮上遠心血液ポンプの流体力を利用した軸受け隙間調整法2013

    • Author(s)
      小阪 亮、吉田文彦、西田 正浩、丸山 修、山根 隆志
    • Organizer
      医工連携フォーラム2013
    • Place of Presentation
      つくば
    • Related Report
      2012 Research-status Report
  • [Presentation] 市販遠心血液ポンプ装置で非接触駆動可能なディスポーザブル式動圧浮上血液ポンプの開発2013

    • Author(s)
      小阪 亮、村重 智崇、西田 正浩、丸山 修、桑名克之、山根 隆志
    • Organizer
      第41回人工心臓と補助循環懇話会学術集会
    • Place of Presentation
      長野県湯田中
    • Related Report
      2012 Research-status Report
  • [Presentation] 軸受剛性と血液適合性を考慮した動圧浮上遠心血液ポンプのスラスト軸受形状の数値解析的検討2013

    • Author(s)
      村重智崇、小阪亮、西田正浩、丸山修、山根隆志、川口靖夫
    • Organizer
      第25回バイオエンジニアリング講演会
    • Place of Presentation
      つくば
    • Related Report
      2012 Research-status Report
  • [Presentation] 動圧軸受式遠心血液ポンプのラジアル軸受における半径隙間と溶血の関係2013

    • Author(s)
      安井 和哉、小阪亮、丸山修、西田正浩、川口靖夫、山根 隆志
    • Organizer
      第25回バイオエンジニアリング講演会
    • Place of Presentation
      つくば
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of the design of the hydrodynamic radial bearing on impeller stability and hemolysis for a centrifugal blood pump2013

    • Author(s)
      安井 和哉、小阪亮、丸山修、西田正浩、川口靖夫、山根 隆志
    • Organizer
      医工連携フォーラム2013
    • Place of Presentation
      つくば
    • Related Report
      2012 Research-status Report
  • [Presentation] 軸受剛性と血液適合性向上を目的とした動圧浮上遠心血液ポンプのスパイラルグルーブ形状の数値解析的検討2013

    • Author(s)
      村重智崇、小阪亮、西田正浩、丸山修、山根隆志、川口靖夫
    • Organizer
      医工連携フォーラム2013
    • Place of Presentation
      つくば
    • Related Report
      2012 Research-status Report
  • [Presentation] 動圧浮上遠心血液ポンプ用スパイラルグルーブ形状の数値解析的検討2013

    • Author(s)
      村重智崇、小阪亮、西田正浩、丸山修、山根隆志、川口靖夫
    • Organizer
      第12回 産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      つくば
    • Related Report
      2012 Research-status Report
  • [Presentation] 動圧浮上遠心血液ポンプの多円弧軸受形状がインペラのラジアル安定性と溶血に及ぼす影響2013

    • Author(s)
      安井 和哉、小阪亮、丸山修、西田正浩、川口靖夫、山根 隆志
    • Organizer
      第22回ライフサポート学会フロンティア講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Bearing gap control for a hydrodynamically levitated centrifugal pump using a hydraulic force balance2012

    • Author(s)
      Kosaka R, Yoshida F, Nishida M, Maruyama O,Yamane T
    • Organizer
      20th Congress of the ISRBP
    • Place of Presentation
      Turkey
    • Related Report
      2012 Research-status Report
  • [Presentation] Optimal Design of the Multi-arc Hydrodynamic Bearing in a Centrifugal Blood Pump for Improvement of Bearing Stiffness and Hemolysis Level2012

    • Author(s)
      Yasui K, Kosaka R, Nishida M, Maruyama O, Kawaguchi Y, Yamane T
    • Organizer
      20th Congress of the ISRBP
    • Place of Presentation
      Turkey
    • Related Report
      2012 Research-status Report
  • [Presentation] 動圧軸受を用いたディスポーザブル遠心血液ポンプの開発2012

    • Author(s)
      小阪 亮、村重 智崇、西田 正浩、丸山 修、桑名克之、山根 隆志
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 長期補助循環を目的とした動圧浮上遠心血液ポンプの開発2012

    • Author(s)
      小阪 亮、西田 正浩、丸山 修、山根 隆志
    • Organizer
      日本定常流ポンプ研究会2012
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 体外型補助循環を目的とした動圧浮上遠心血液ポンプのスラスト軸受隙間が溶血特性に与える影響2012

    • Author(s)
      村重智崇、小阪亮、西田正浩、丸山修、山根隆志、桑名克之、川口靖夫
    • Organizer
      2012日本機械学会関東支部茨城講演会
    • Place of Presentation
      日立
    • Related Report
      2012 Research-status Report
  • [Presentation] 軸受剛性の確保を主眼とした人工心臓用多円弧動圧軸受の最適設計2012

    • Author(s)
      安井 和哉、小阪亮、丸山修、西田正浩、川口靖夫、山根 隆志
    • Organizer
      2012日本機械学会関東支部茨城講演会
    • Place of Presentation
      日立
    • Related Report
      2012 Research-status Report
  • [Presentation] 動圧軸受式人工心臓の軸受剛性と溶血特性の改善を目指した多円弧動圧軸受の開発2012

    • Author(s)
      安井 和哉、小阪亮、丸山修、西田正浩、川口靖夫、山根 隆志
    • Organizer
      日本機械学会 2012年度年次大会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2012 Research-status Report
  • [Presentation] 軸受剛性と血液適合性に優れる多円弧動圧軸受式遠心血液ポンプの開発2012

    • Author(s)
      安井 和哉、小阪亮、丸山修、西田正浩、川口靖夫、山根 隆志
    • Organizer
      第28回 ライフサポート学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 体外型補助循環を目的とした動圧浮上遠心血液ポンプのスラスト最小軸受隙間が溶血に与える影響2012

    • Author(s)
      村重智崇、小阪亮、西田正浩、丸山修、山根隆志、桑名克之、川口靖夫
    • Organizer
      第28回 ライフサポート学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 遠心血液ポンプにおけるラジアル動圧軸受の半径隙間と溶血の関係2012

    • Author(s)
      安井 和哉、小阪亮、丸山修、西田正浩、川口靖夫、山根 隆志
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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