Investigating mechanisms of ventricular arrhythmias induced in the Purkinje fiber network using computer simulation
| Project/Area Number |
24700470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
HARAGUCHI Ryo 独立行政法人国立循環器病研究センター, 情報統括部, 室長 (00393215)
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| Research Collaborator |
ASHIHARA Takashi 滋賀医科大学, 医学部, 助教(学内講師) (80396259)
TSUMOTO Kunichika 大阪大学, 医学研究科, 助教 (70353331)
YAMAGUCHI Takeshi 四国大学, 看護学 (60532182)
NAKAZAWA Kazuo 国立循環器病研究センター, 研究所, 室長 (50198058)
INADA Shin 国立循環器病研究センター, 研究所, 特任研究員 (50349792)
HARRELL Daniel T. 長崎大学
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 不整脈 / シミュレーション / 生体システム・フィジオーム |
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| Outline of Final Research Achievements |
Cardiac conduction system plays an important role in heart as a blood pump. Purkinje fiber network that run throughout the ventricles inside may be responsible for various arrhythmias. Our computer simulation results suggest that both morphological characters and electrical conductivity of Purkinje fiber network are important factor for arrhythmia occurrence of Purkinje origin. We performed computer simulations with 3-D model involved in electrophysiological model of a human purkinje/ventricular cell. Furthermore, we performed the 3D reconstruction of cardiac conduction system based on serial histological specimens. These technologies will lead to the construction of a simulation model which is electrophysiologically and morphologically reasonable.
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Report
(4 results)
Research Products
(44 results)
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[Presentation] Investigating excitation conduction in the atrioventricular node and Purkinje network using computer simulation2014
Author(s)
Shin Inada, Daniel T. Harrell, Takako Ono, Nitaro Shibata, Ryo Haraguchi, Takashi Ashihara, Takanori Ikeda, Kazuyuki Mitsui, Halina Dobrzynski, Mark R. Boyett, Naomasa Makita, Kazuo Nakazawa
Organizer
The 9th Tawara-Aschoff Symposium
Place of Presentation
東京
Year and Date
2014-07-26 – 2014-07-27
Related Report
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[Presentation] SIMULATION STUDY OF VENTRICULAR RATE CONTROL THERAPY DURING ATRIAL FIBRILLATION USING ONE-DIMENSIONAL CABLE MODEL WITH TWO CONDUCTION PATHWAYS
Author(s)
Inada, S. Ono, T. Shibata, N. Iwata, M. Haraguchi, R. Ashihara, T. Abe, A. Ikeda, T. Mitsui, K. Boyett, M.R. Dobrzynski, H. Nakazawa, K
Organizer
40th International Congress on Electrocardiology
Place of Presentation
Glasgow
Related Report
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[Presentation] Multi-scale simulation studies of excitation conduction from the sinoatrial node to the ventricles in the heart
Author(s)
Shin Inada, Daniel T. Harrel, Takako Ono, Ryo Haraguchi, Takashi Ashihara, Halina Dobrzynski, Haruo Honjo, Nitaro Shibata, Takanori Ikeda, Kazuyuki Mitsui, Naomasa Makita, Itsuo Kodama, Mark R. Boyett, Kazuo Nakazawa
Organizer
The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
Place of Presentation
東京
Related Report
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