• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigating mechanisms of ventricular arrhythmias induced in the Purkinje fiber network using computer simulation

Research Project

Project/Area Number 24700470
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

HARAGUCHI Ryo  独立行政法人国立循環器病研究センター, 情報統括部, 室長 (00393215)

Research Collaborator ASHIHARA Takashi  滋賀医科大学, 医学部, 助教(学内講師) (80396259)
TSUMOTO Kunichika  大阪大学, 医学研究科, 助教 (70353331)
YAMAGUCHI Takeshi  四国大学, 看護学 (60532182)
NAKAZAWA Kazuo  国立循環器病研究センター, 研究所, 室長 (50198058)
INADA Shin  国立循環器病研究センター, 研究所, 特任研究員 (50349792)
HARRELL Daniel T.  長崎大学
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords不整脈 / シミュレーション / 生体システム・フィジオーム
Outline of Final Research Achievements

Cardiac conduction system plays an important role in heart as a blood pump. Purkinje fiber network that run throughout the ventricles inside may be responsible for various arrhythmias. Our computer simulation results suggest that both morphological characters and electrical conductivity of Purkinje fiber network are important factor for arrhythmia occurrence of Purkinje origin. We performed computer simulations with 3-D model involved in electrophysiological model of a human purkinje/ventricular cell. Furthermore, we performed the 3D reconstruction of cardiac conduction system based on serial histological specimens. These technologies will lead to the construction of a simulation model which is electrophysiologically and morphologically reasonable.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (44 results)

All 2015 2014 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (41 results) (of which Invited: 3 results)

  • [Journal Article] Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study2014

    • Author(s)
      Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
    • Journal Title

      PLOS ONE

      Volume: 9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation : Implications for electrogram-based catheter ablation2012

    • Author(s)
      Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Ito M, Horie M, Trayanova NA
    • Journal Title

      Circ Res

      Volume: 110 Issue: 2 Pages: 275-284

    • DOI

      10.1161/circresaha.111.255026

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Kinematic Approach for Efficient and Robust Simulation of the Cardiac Beating Motion2012

    • Author(s)
      Ijiri T, Ashihara T, Umetani N, Igarashi T, Haraguchi R, Yokota H, Nakazawa K
    • Journal Title

      PloS One

      Volume: 7(5) Issue: 5 Pages: 1-9

    • DOI

      10.1371/journal.pone.0036706

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Computational Heart Modelを用いた臓研究の紹介2015

    • Author(s)
      原口 亮
    • Organizer
      生体医用画像研究会 第2回若手発表会
    • Place of Presentation
      吹田
    • Year and Date
      2015-03-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Ventricular arrhythmias generated from Purkinje fiber network with gap junction mutation - A simulaton study -2015

    • Author(s)
      Shin Inada, Daniel T. Harrell, Ryo Haraguchi, Takashi Ashihara, Naomasa Makita, Kazuo Nakazawa
    • Organizer
      The Final HD Physiology Symposium
    • Place of Presentation
      大阪
    • Year and Date
      2015-03-04 – 2015-03-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 病理組織標本デジタル画像からの3次元可視化における表現手法の改善2015

    • Author(s)
      原口 亮,瀬尾 拡史,松山 高明,森田 佳明,岩田 倫明,長谷川 周平,植田 初江
    • Organizer
      メディカルイメージング連合フォーラム2014
    • Place of Presentation
      石垣
    • Year and Date
      2015-03-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Investigating excitation conduction in the atrioventricular node and Purkinje network using computer simulation2014

    • Author(s)
      Shin Inada, Daniel T. Harrell, Takako Ono, Nitaro Shibata, Ryo Haraguchi, Takashi Ashihara, Takanori Ikeda, Kazuyuki Mitsui, Halina Dobrzynski, Mark R. Boyett, Naomasa Makita, Kazuo Nakazawa
    • Organizer
      The 9th Tawara-Aschoff Symposium
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ischemia-induced Subcellular Sodium Channel Redistribution as a Mechanism of Arrhythmogenic Effect of Class-I Antiarrhythmic Drugs on Ventricle: A Simulation Study2014

    • Author(s)
      Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
    • Organizer
      第29回日本不整脈学会学術大会 第31回日本心電学会学術集会 合同開催
    • Place of Presentation
      東京
    • Year and Date
      2014-07-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ventricular arrhythmia induced by the Purkinje network with reduced gap junction conductance - A simulation study -2014

    • Author(s)
      Shin Inada, Daniel Harrell, Ryo Haraguchi, Takashi Ashihara, Naomasa Makita, Kazuo Nakazawa
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 虚血境界域における細胞内Naチャネル分布リモデリングがNaチャネル遮断薬による催不整脈作用に関与する可能性について2014

    • Author(s)
      津元国親, 芦原貴司, 原口亮, 中沢一雄, 倉智嘉久
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 虚血境界域におけるNaチャネルの細胞内リモデリングがリエントリー性心室頻拍の機序に関与する可能性について2014

    • Author(s)
      津元国親, 芦原貴司, 原口亮, 中沢一雄, 倉智嘉久
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
  • [Presentation] A Gap Junction Mutation Expressed in the Purkinje Network and Lethal Ventricular Arrhythmias - A Simulation Study -

    • Author(s)
      Shin Inada, Daniel Toshio Harrell, Ryo Haraguchi, Takashi Ashihara, Naomasa Makita, Kazuo Nakazawa
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 病理組織標本デジタル画像を用いた心臓刺激伝導系の3次元可視化

    • Author(s)
      原口 亮,瀬尾拡史,松山高明,岩田倫明,長谷川周平,大藤康一朗,植田初江
    • Organizer
      メディカルイメージング連合フォーラム
    • Place of Presentation
      那覇
    • Related Report
      2013 Research-status Report
  • [Presentation] Rotational Anisotropy Prevents Transition of Tachycardia to Fibrillation in the Ventricular Wall Model: A Simulation Study

    • Author(s)
      R. Haraguchi, T. Ashihara, S. Inada, T. Ikeda, K. Nakazawa
    • Organizer
      6th APHRS & CardioRhythm 2013
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Research-status Report
  • [Presentation] Simulation Studies of Tachyarrhythmias in a 3-D Ventricular Wall Model: Implications for Electrophysiological Heterogeneity and Rotational Anisotropy

    • Author(s)
      Ryo Haraguchi, Takashi Ashihara, Shin Inada, Takanori Ikeda, Kazuo Nakazawa
    • Organizer
      35th Annual International Conference of the IEEE EMBS
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Simulation of Excitation Propagation in the Novel Brick-Wall Model of Ventricular Myocardium

    • Author(s)
      Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
    • Organizer
      35th Annual International Conference of the IEEE EMB
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Rotational Anisotropy Prevents Transition of Tachycardia to Fibrillation in Ventricles under the Large Transmural Dispersion ofRepolarizatiou -A Simulation Study -

    • Author(s)
      Ryo Haraguchi, Takashi Ashihara, Shin Inada, Takanori Ikeda, Kazuo Nakazawa
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Reentrant Beat in the Purkinje Network Associated with Gap Junction Mutation -A Simulation Study-

    • Author(s)
      Shin Inada, Daniel T. Harrell, Ryo Haraguchi, Takashi Ashihara, Naomasa Makita, Kazuo Nakazawa
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 高頻度心房興奮に対する房室結節の応答一シミュレーションによる検討一

    • Author(s)
      稲田慎,小野多佳子,柴田仁太郎,原口亮,芦原貴司,Halina Dobrzynski,Mark R. Boyett,三井和幸,池田隆徳,中沢一雄
    • Organizer
      第29回心電情報処理ワークショップ
    • Place of Presentation
      熱海
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒトiPS細胞分化心筋シートの薬効評価への応用可能性:in silico不整脈学の観点から

    • Author(s)
      芦原貴司,原口 亮,中沢一雄,伊藤 誠,堀江 稔
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 虚血心筋における細胞内Na+チャネル分布リモデリングのI群抗不整脈薬による催不整脈増強作用

    • Author(s)
      津元国親,芦原貴司,原口 亮,中沢一雄,倉智嘉久
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 心房細動に対するチャネルブロッカーのレートコントロール効果に関するシミュレーション研究 -Ca2+ブロックとK+プロックの比較ー

    • Author(s)
      小野多佳子,稲田 慎,柴田仁太郎,原口 亮,Halina Dobrzynskj,Mark R. Boyett,三井和幸,中沢一雄
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 心房細動に対するジギタリスおよびβ遮断によるレートコントロール機序のコンピュータシミュレーションによる検討

    • Author(s)
      稲田 慎,小野多佳子,柴田仁太郎,原口 亮,芦原貴司,Halina Dobrzynski, Mark Boyett,三井和幸,池田隆徳,中沢一雄
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] SIMULATION STUDY OF VENTRICULAR RATE CONTROL THERAPY DURING ATRIAL FIBRILLATION USING ONE-DIMENSIONAL CABLE MODEL WITH TWO CONDUCTION PATHWAYS

    • Author(s)
      Inada, S. Ono, T. Shibata, N. Iwata, M. Haraguchi, R. Ashihara, T. Abe, A. Ikeda, T. Mitsui, K. Boyett, M.R. Dobrzynski, H. Nakazawa, K
    • Organizer
      40th International Congress on Electrocardiology
    • Place of Presentation
      Glasgow
    • Related Report
      2013 Research-status Report
  • [Presentation] FUNCTIONAL PROPERTIES OF COMPLEX FRACTIONATED ATRIAL ELECTROGRAMS DURING ATRIAL FIBRILLATION CAN BE EXPLAINED BY STRUCTURAL REMODELING: A SIMULATION STUDY

    • Author(s)
      Ashihara, T. Haraguchi, R. Inada, K. Nakazawa, S. Ikeda, T. Ozawa, T. Ito, M. Trayanova, N. Horie, M.
    • Organizer
      40th International Congress on Electrocardiology
    • Place of Presentation
      Glasgow
    • Related Report
      2013 Research-status Report
  • [Presentation] Simulation study of complex action potential conduction in atrioventricular node

    • Author(s)
      Shin Inada, Takako Ono, Nitaro Shibata, Michiaki Iwata, Ryo Haraguchi, Takashi Ashihara, Kazuyuki Mitsui, Mark R. Boyett, Halina Dobrzynski and Kazuo Nakazawa
    • Organizer
      35th Annual International Conference of the IEEE EMBS
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Proarrhythmic Effects of Class-I Antiarrhythmic Agents Enhanced by Ischemia-Induced Subcellular Remodeling of Sodium Channels

    • Author(s)
      Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, and Yoshihisa Kurachi
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Multi-scale simulation studies of excitation conduction from the sinoatrial node to the ventricles in the heart

    • Author(s)
      Shin Inada, Daniel T. Harrel, Takako Ono, Ryo Haraguchi, Takashi Ashihara, Halina Dobrzynski, Haruo Honjo, Nitaro Shibata, Takanori Ikeda, Kazuyuki Mitsui, Naomasa Makita, Itsuo Kodama, Mark R. Boyett, Kazuo Nakazawa
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 心筋Naチャネル遮断による催不整脈リスクは虚血境界領域のNaチャネルリモデリングで説明できる

    • Author(s)
      津元国親
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 心拍制御メカニズムの解明を目指した心房心室間興奮伝導シミュレーション

    • Author(s)
      小野多佳子
    • Organizer
      電子情報通信学会MEとバイオサイバネティックス研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 虚血心筋におけるNaチャネルの細胞内分布変化がI群抗不整脈薬の催不整脈性の機序に関与する可能性について

    • Author(s)
      津元 国親
    • Organizer
      第28回心電情報処理ワークショップ
    • Place of Presentation
      熱海
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性心房細動における種々のComplex Fractionated Atrial Electrogramは構造的リモデリングの進展で説明できるか?

    • Author(s)
      芦原 貴司
    • Organizer
      第28回心電情報処理ワークショップ
    • Place of Presentation
      熱海
    • Related Report
      2012 Research-status Report
  • [Presentation] 陳旧性心筋梗塞下におけるI群抗不整脈薬の催不整脈作用の機序:心筋Naチャネルの虚血誘発性細胞内リモデリングとの関連において

    • Author(s)
      津元国親
    • Organizer
      第22回日本循環薬理学会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
  • [Presentation] 心房細動状態における房室結節を中心とした活動電位の伝導シミュレーション

    • Author(s)
      小野 多佳子
    • Organizer
      第28回心電情報処理ワークショップ
    • Place of Presentation
      熱海
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性心房細動における Complex Fractionated Atrial Electrogram は機能的か?:シミュレーションによる理論的検討

    • Author(s)
      芦原貴司
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2012 Research-status Report
  • [Presentation] 心外膜面局所冷却による除細動の可能性:3次元心室壁モデルを用いたシミュレーションによる検討

    • Author(s)
      稲田 慎
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2012 Research-status Report
  • [Presentation] 多重房室伝導路のウェンケバッハ現象および心房細動時における心室応答に対する重要性

    • Author(s)
      小野多佳子
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2012 Research-status Report
  • [Presentation] 心筋Na+チャネルの細胞内局在によって発生するPhase-2リエントリー:Brugada症候群との関連において

    • Author(s)
      津元国親
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2012 Research-status Report
  • [Presentation] 心筋線維走向ねじれは心室較差増大による催不整脈を抑制する:3次元心室壁モデルによるシミュレーション研究

    • Author(s)
      原口 亮
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2012 Research-status Report
  • [Presentation] 2つに分岐したケーブルモデルを用いた心房心室間興奮伝導シミュレーション

    • Author(s)
      小野 多佳子
    • Organizer
      生体医工学シンポジウム2012
    • Place of Presentation
      豊中
    • Related Report
      2012 Research-status Report
  • [Presentation] 致死的不整脈防御機構としての心室較差の電気生理学的意義~シミュレーションによる検討 ~

    • Author(s)
      原口 亮
    • Organizer
      第51回日本生体医工学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 不整脈臨床医はマルチスケールシミュレーションに何を求めるのか?

    • Author(s)
      芦原貴司
    • Organizer
      第51回日本生体医工学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 2つに分岐した刺激伝導系ケーブルモデルを用いた心房細動時における心室拍動制御のシミュ レーション

    • Author(s)
      小野多佳子
    • Organizer
      第51回日本生体医工学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Investigating effects of cooling on termination of ventricular fibrillation: A simulation study

    • Author(s)
      Shin Inada
    • Organizer
      第51回日本生体医工学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi